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Human protein-coding gene
T-cell leukemia homeobox protein 2 is a protein that in humans is encoded by the TLX2 gene .[ 5] [ 6]
Interactions
TLX2 has been shown to interact with YWHAH .[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000115297 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068327 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Puliti A, Cinti R, Betsos N, Romeo G, Ceccherini I (Jun 1999). "HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1→p12 and mouse chromosome 6C3-D1". Cytogenetics and Cell Genetics . 84 (1–2): 115–7. doi :10.1159/000015234 . PMID 10343123 . S2CID 21498122 .
^ "Entrez Gene: TLX2 T-cell leukemia homeobox 2" .
^ Tang SJ, Suen TC, McInnes RR, Buchwald M (September 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins" . The Journal of Biological Chemistry . 273 (39): 25356–63. doi :10.1074/jbc.273.39.25356 . PMID 9738002 .
Further reading
Kaifi JT, Wagner M, Schurr PG, Wachowiak R, Reichelt U, Yekebas EF, Mann O, Vashist Y, Kleinhans H, Link BC, Strate T, Kalinin V, Izbicki JR (October 2006). "Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors" . Oncology Reports . 16 (4): 915–9. doi :10.3892/or.16.4.915 . PMID 16969514 .
Borghini S, Bachetti T, Fava M, Di Duca M, Cargnin F, Fornasari D, Ravazzolo R, Ceccherini I (April 2006). "The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells" . The Biochemical Journal . 395 (2): 355–61. doi :10.1042/BJ20051386 . PMC 1422762 . PMID 16402914 .
Parisi MA, Lipman NS, Clarke CM, Taylor B, Kapur RP (November 2005). "Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction". Journal of Pediatric Surgery . 40 (11): 1760–5. doi :10.1016/j.jpedsurg.2005.07.010 . PMID 16291166 .
Iitsuka Y, Shimizu H, Kang MM, Sasagawa K, Sekiya S, Tokuhisa T, Hatano M (August 1999). "An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells" . The Journal of Biological Chemistry . 274 (34): 24401–7. doi :10.1074/jbc.274.34.24401 . PMID 10446220 .
Tang SJ, Suen TC, McInnes RR, Buchwald M (September 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins" . The Journal of Biological Chemistry . 273 (39): 25356–63. doi :10.1074/jbc.273.39.25356 . PMID 9738002 .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group C bHLH-PAS Group D Group E Group F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors