NKX2-3

NKX2-3
Identifiers
Aliases	NKX2-3, CSX3, NK2.3, NKX2.3, NKX2C, NKX4-3, NK2 homeobox 3
External IDs	OMIM: 606727 MGI: 97348 HomoloGene: 17061 GeneCards: NKX2-3
Gene location (Human)
Chr.	Chromosome 10 (human)
End	99,536,524 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	43,604,331 bp
RNA expression pattern
	Top expressed in
	spleen; ; transverse colon; ; duodenum; ; sural nerve; ; minor salivary glands; ; jejunal mucosa; ; cecum; ; rectum; ; appendix; ; pylorus;
	Top expressed in
	Hindgut; ; yolk sac; ; Stomodeum; ; duodenum; ; pharyngeal pouch; ; ileum; ; tongue; ; jejunum; ; colon; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; molecular function; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity;
Cellular component	nucleus; cellular component;
Biological process	leukocyte homeostasis; CD4-positive, alpha-beta T cell differentiation; post-embryonic digestive tract morphogenesis; regulation of transcription, DNA-templated; plasma cell differentiation; spleen development; post-embryonic development; transcription, DNA-templated; macrophage differentiation; mucosa-associated lymphoid tissue development; odontogenesis of dentin-containing tooth; gland morphogenesis; regulation of cell population proliferation; immune response; B cell differentiation; Peyer's patch development; digestive tract development; lymph node development; triglyceride metabolic process; leukocyte migration; positive regulation of transcription by RNA polymerase II; biological process; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	159296
	18089
	ENSG00000119919
	ENSMUSG00000044220
	Q8TAU0
	P97334
	NM_145285
	NM_008699
	NP_660328
	NP_032725
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.^[5]^[6]^[7]

NKX2C is a member of the NKX family of homeodomain-containing transcription factors, which are implicated in many aspects of cell type specification and maintenance of differentiated tissue functions.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119919 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044220 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R (Mar 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–55. doi:10.1016/0896-6273(92)90291-K. PMID 1346742. S2CID 22766848.
^ Pabst O, Schneider A, Brand T, Arnold HH (Jul 1997). "The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development". Dev Dyn. 209 (1): 29–35. doi:10.1002/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z. PMID 9142493.
^ ^a ^b "Entrez Gene: NKX2-3 NK2 transcription factor related, locus 3 (Drosophila)".

Harvey RP (1996). "NK-2 homeobox genes and heart development". Dev. Biol. 178 (2): 203–16. doi:10.1006/dbio.1996.0212. PMID 8812123.
Pabst O, Zweigerdt R, Arnold HH (1999). "Targeted disruption of the homeobox transcription factor Nkx2-3 in mice results in postnatal lethality and abnormal development of small intestine and spleen". Development. 126 (10): 2215–25. doi:10.1242/dev.126.10.2215. PMID 10207146.
Phiel CJ, Gabbeta V, Parsons LM, et al. (2001). "Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues". J. Biol. Chem. 276 (37): 34637–50. doi:10.1074/jbc.M105826200. PMID 11457859.
Biben C, Wang CC, Harvey RP (2003). "NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis". Int. J. Dev. Biol. 46 (4): 415–22. PMID 12141427.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119919 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044220 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1346742-5] Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R (Mar 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–55. doi:10.1016/0896-6273(92)90291-K. PMID 1346742. S2CID 22766848.

[pmid9142493-6] Pabst O, Schneider A, Brand T, Arnold HH (Jul 1997). "The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development". Dev Dyn. 209 (1): 29–35. doi:10.1002/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z. PMID 9142493.

[entrez-7] "Entrez Gene: NKX2-3 NK2 transcription factor related, locus 3 (Drosophila)".

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References

Further reading