Sterol regulatory element-binding protein 2

Source: Wikipedia, the free encyclopedia.
(Redirected from SREBF2)
SREBF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSREBF2, SREBP-2, SREBP2, bHLHd2, sterol regulatory element binding transcription factor 2
External IDsOMIM: 600481 MGI: 107585 HomoloGene: 20966 GeneCards: SREBF2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004599

NM_033218

RefSeq (protein)

NP_004590

NP_150087

Location (UCSC)Chr 22: 41.83 – 41.91 MbChr 15: 82.03 – 82.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene.[5]

Function

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix leucine zipper (bHLH-Zip) domain.[6] Various single nucleotide polymorphisms (SNPs) of the SREBF2 have been identified and some of them are found to be associated with higher risk of knee osteoarthritis. [7]

Interactions

SREBF2 has been shown to interact with INSIG1[8][9] and CREB-binding protein.[10]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198911 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022463 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X (Dec 1993). "SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element". Proceedings of the National Academy of Sciences of the United States of America. 90 (24): 11603–7. Bibcode:1993PNAS...9011603H. doi:10.1073/pnas.90.24.11603. PMC 48032. PMID 7903453.
  6. ^ "Entrez Gene: SREBF2 sterol regulatory element binding transcription factor 2".
  7. ^ Qiu XM, Jin CT, Wang W (Apr 2014). "Association between single nucleotide polymorphisms of sterol regulatory element binding protein-2 gene and risk of knee osteoarthritis in a Chinese Han population". The Journal of International Medical Research. 42 (2): 320–8. doi:10.1177/0300060513507392. PMID 24496149.
  8. ^ Dobrosotskaya IY, Goldstein JL, Brown MS, Rawson RB (Sep 2003). "Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs". The Journal of Biological Chemistry. 278 (37): 35837–43. doi:10.1074/jbc.M306476200. PMID 12842885.
  9. ^ Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS (Aug 2002). "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER". Cell. 110 (4): 489–500. doi:10.1016/S0092-8674(02)00872-3. PMID 12202038. S2CID 15052132.
  10. ^ Oliner JD, Andresen JM, Hansen SK, Zhou S, Tjian R (Nov 1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein". Genes & Development. 10 (22): 2903–11. doi:10.1101/gad.10.22.2903. PMID 8918891.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This page is based on the copyrighted Wikipedia article: SREBF2. Articles is available under the CC BY-SA 3.0 license; additional terms may apply.Privacy Policy