NKX6-1

NKX6-1
Identifiers
Aliases	NKX6-1, NKX6.1, NKX6A, NK6 homeobox 1
External IDs	OMIM: 602563 MGI: 1206039 HomoloGene: 4495 GeneCards: NKX6-1
Gene location (Human)
Chr.	Chromosome 4 (human)
End	84,499,292 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	101,812,862 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; islet of Langerhans; ; body of pancreas; ; stromal cell of endometrium; ; left lobe of thyroid gland; ; substantia nigra; ; hypothalamus; ; right lobe of thyroid gland; ; spinal cord; ; putamen;
	Top expressed in
	islet of Langerhans; ; stria vascularis; ; facial motor nucleus; ; esophagus; ; spinal cord; ; anterior horn of spinal cord; ; cochlea; ; aortic valve; ; ascending aorta; ; supraoptic nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; chromatin binding; DNA-binding transcription factor activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; extracellular exosome;
Biological process	smoothened signaling pathway; detection of glucose; pancreas development; transcription, DNA-templated; regulation of axon extension; multicellular organism development; cellular response to peptide hormone stimulus; central nervous system neuron differentiation; response to nicotine; negative regulation of glial cell differentiation; type B pancreatic cell proliferation; cellular response to cytokine stimulus; positive regulation of DNA-binding transcription factor activity; neurogenesis; regulation of transcription by RNA polymerase II; type B pancreatic cell development; positive regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; positive regulation of type B pancreatic cell development; type B pancreatic cell maturation; oligodendrocyte differentiation; regulation of transcription, DNA-templated; cell population proliferation; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; positive regulation of glial cell differentiation; cell differentiation; positive regulation of insulin secretion; animal organ morphogenesis; regulation of neuron migration; neuron migration; regulation of insulin secretion; endocrine pancreas development; type B pancreatic cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	4825
	18096
	ENSG00000163623
	ENSMUSG00000035187
	P78426
	Q99MA9
	NM_006168
	NM_144955
	NP_006159
	NP_659204
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.^[5]^[6]

Function

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163623 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035187 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Inoue H, Rudnick A, German MS, Veile R, Donis-Keller H, Permutt MA (March 1997). "Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene". Genomics. 40 (2): 367–70. doi:10.1006/geno.1996.4568. PMID 9119408.
^ ^a ^b "Entrez Gene: NK6 homeobox 1".

Schisler JC, Fueger PT, Babu DA, et al. (2008). "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1". Mol. Cell. Biol. 28 (10): 3465–76. doi:10.1128/MCB.01791-07. PMC 2423154. PMID 18347054.
Hori Y, Gu X, Xie X, Kim SK (2005). "Differentiation of insulin-producing cells from human neural progenitor cells". PLOS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMC 1087208. PMID 15839736.
Jørgensen MC, Vestergírd Petersen H, Ericson J, et al. (1999). "Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1". FEBS Lett. 461 (3): 287–94. doi:10.1016/S0014-5793(99)01436-2. PMID 10567713. S2CID 1735843.
Iype T, Taylor DG, Ziesmann SM, et al. (2004). "The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1". Mol. Endocrinol. 18 (6): 1363–75. doi:10.1210/me.2004-0006. PMID 15056733.
Yokoi N, Kanamori M, Horikawa Y, et al. (2006). "Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects". Diabetes. 55 (8): 2379–86. doi:10.2337/db05-1203. PMID 16873704.
Zhu S, Xia HH, Yang Y, et al. (2009). "Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia". Dig. Dis. Sci. 54 (5): 996–1002. doi:10.1007/s10620-008-0459-8. PMID 18754095. S2CID 25173708.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163623 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035187 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9119408-5] Inoue H, Rudnick A, German MS, Veile R, Donis-Keller H, Permutt MA (March 1997). "Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene". Genomics. 40 (2): 367–70. doi:10.1006/geno.1996.4568. PMID 9119408.

[entrez-6] "Entrez Gene: NK6 homeobox 1".

[1]

[2]

[3]

[4]

[5]

[6]

Function

References

Further reading