Cationic amino acid transporter 2

SLC7A2
Identifiers
Aliases	SLC7A2, ATRC2, CAT2, HCAT2, solute carrier family 7 member 2
External IDs	OMIM: 601872; MGI: 99828; HomoloGene: 20659; GeneCards: SLC7A2; OMA:SLC7A2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	17,570,573 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	41,375,345 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; islet of Langerhans; ; right lobe of liver; ; trigeminal ganglion; ; gastrocnemius muscle; ; bronchial epithelial cell; ; retinal pigment epithelium; ; right ovary;
	Top expressed in
	epithelium of lens; ; Dermatocranium; ; membranous bone; ; left lobe of liver; ; mandible; ; maxilla; ; muscle of thigh; ; secondary oocyte; ; islet of Langerhans; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	high-affinity lysine transmembrane transporter activity; low-affinity L-arginine transmembrane transporter activity; L-arginine transmembrane transporter activity; basic amino acid transmembrane transporter activity; high-affinity L-arginine transmembrane transporter activity; high-affinity L-ornithine transmembrane transporter activity; L-ornithine transmembrane transporter activity; L-lysine transmembrane transporter activity; amino acid transmembrane transporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; plasma membrane; cell junction;
Biological process	nitric oxide biosynthetic process; cellular amino acid metabolic process; nitric oxide production involved in inflammatory response; regulation of inflammatory response; L-lysine import across plasma membrane; L-arginine import across plasma membrane; L-ornithine import across plasma membrane; macrophage activation; L-ornithine transmembrane transport; amino acid transport; regulation of macrophage activation; transmembrane transport; L-lysine transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6542
	11988
	ENSG00000003989
	ENSMUSG00000031596
	P52569
	P18581
	NM_001008539; NM_001164771; NM_003046; NM_001370337; NM_001370338
	NM_001044740; NM_007514
	NP_001008539; NP_001158243; NP_003037; NP_001357266; NP_001357267
	NP_001038205; NP_031540
	Wikidata
View/Edit Human	View/Edit Mouse

Cationic amino acid transporter 2 is a protein that in humans is encoded by the SLC7A2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000003989 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031596 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hoshide R, Ikeda Y, Karashima S, Matsuura T, Komaki S, Kishino T, Niikawa N, Endo F, Matsuda I (Mar 1997). "Molecular cloning, tissue distribution, and chromosomal localization of human cationic amino acid transporter 2 (HCAT2)". Genomics. 38 (2): 174–8. doi:10.1006/geno.1996.0613. PMID 8954799.
^ "Entrez Gene: SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2".

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
González M, Flores C, Pearson JD, et al. (2005). "Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells". Pflügers Arch. 448 (4): 383–94. doi:10.1007/s00424-004-1261-x. PMID 15064952. S2CID 25238852.
Schnorr O, Suschek CV, Kolb-Bachofen V (2003). "The importance of cationic amino acid transporter expression in human skin". J. Invest. Dermatol. 120 (6): 1016–22. doi:10.1046/j.1523-1747.2003.12139.x. PMID 12787129.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hammermann R, Brunn G, Racké K (2002). "Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4". Amino Acids. 21 (2): 211–9. doi:10.1007/s007260170029. PMID 11665818. S2CID 30892800.
Closs EI, Gräf P, Habermeier A, et al. (1997). "Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties". Biochemistry. 36 (21): 6462–8. doi:10.1021/bi962829p. PMID 9174363.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000003989 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031596 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8954799-5] Hoshide R, Ikeda Y, Karashima S, Matsuura T, Komaki S, Kishino T, Niikawa N, Endo F, Matsuda I (Mar 1997). "Molecular cloning, tissue distribution, and chromosomal localization of human cationic amino acid transporter 2 (HCAT2)". Genomics. 38 (2): 174–8. doi:10.1006/geno.1996.0613. PMID 8954799.

[entrez-6] "Entrez Gene: SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2".

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Cationic amino acid transporter 2

See also

References

Further reading