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Chemical compound
(–)-2β-Carbomethoxy-3β-(4-tolyl )tropane (RTI-4229 -32 , tolpane ) is a phenyltropane -based cocaine analogue that has similar properties in vitro to related drugs such as RTI-31 .[ 1] [ 2]
Comparison of Data
Compound DAT
DA
NET
NA
SERT
5HT
ED50
Troparil 23
49.8
550
37.2
178
173
0.34
RTI-32
1.7
7.02
36
8.42
23
19.4
0.31
RTI-31 1.1
3.68
22
5.86
4.0
5.0
0.13
3'4'-xylyl
0.43
unknown
44
unknown
2.42
unknown
See also
References
^ Remy P, Doder M, Lees A, Turjanski N, Brooks D (June 2005). "Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system" . Brain . 128 (Pt 6): 1314–22. doi :10.1093/brain/awh445 PMID 15716302 . ^ Xu L, Izenwasser S, Katz JL, Kopajtic T, Klein-Stevens C, Zhu N, et al. (March 2002). "Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters". Journal of Medicinal Chemistry . 45 (6): 1203–10. doi :10.1021/jm010453u . PMID 11881989 .
2-Carboxymethyl Esters (3,4-Disubstituted Phenyl)-tropanes Arylcarboxy Carboxyalkyl Acyl β,α Stereochemistry α,β Stereochemistry Heterocycles: 3-Substituted-isoxazol-5-yl Heterocycles: 3-Substituted-1,2,4-oxadiazole N-alkyl N-replaced (S,O,C) Irreversible Nortropanes (N-demethylated)
