Wikipedia:Featured article candidates/Cell nucleus

Cell nucleus

This A-class article was the subject of the molecular and cellular biology collaboration in September, and was barely more than a stub before we started work. Much of the credit for the work and collaboration coordination goes to ShaiM, who is currently on a break, with contributions from myself and many members of the MCB project. The article had a brief peer review in October, archived here. Comments on this critical article in cell biology would be appreciated. Thanks. Opabinia regalis 03:49, 15 December 2006 (UTC)[reply]

Support, for what it's worth. I'm admittedly biased, but we worked hard on this to make it into what it is, and I'm satisfied that it's complete. – Clockwork Soul 04:03, 15 December 2006 (UTC)[reply]
Support. A shorter version of the lede will have to be created for it to go on the front page. I'm sure you guys are working on this. Samsara (talk • contribs) 12:19, 15 December 2006 (UTC)[reply]
Yes, the summary must be summarized summarily. Wow, I'm a dork. – Clockwork Soul 15:11, 15 December 2006 (UTC)[reply]
There are three 2-3 sentence sections in the middle of the article. It's not clear why they need their own section headers. Otherwise, good. Christopher Parham (talk) 16:37, 15 December 2006 (UTC)[reply]

The subnuclear bodies sections could be a bulleted list, I suppose. I liked having them clearly demarcated in some way that makes it obvious how the descriptions relate to the table. Opabinia regalis 01:33, 16 December 2006 (UTC)[reply]

Comments

~~In the introduction, its not clear what this means "It was later popularized by Scottish botanist Robert Brown in 1831." When was the cell nucleus ever popular? :)~~

What, you mean it's unpopular? Well, I like my nuclei, anyway... :) Reworded.

*Units of measurement should be spelled out on first use Style guide (such as μM)

Fixed the ones I found.

Are all Karyopherins really transcription factors? "Most proteins, ribosomal subunits, and some RNAs are transported through the pore complexes in a process mediated by a family of transcription factors known as karyopherins."

Err, that should say "transport factors". Fixed, good catch.

*Need to stick to either US or real English. I caught a few British spellings and changed them to US English, since this seems to predominate.

Fixed the ones I found (two uses of 'organised'). So what, the US uses fake English now? ;)

*The changes in sub-cellular localisation of Hexokinase seems to have more to do with transcriptional control than direct control of enzyme activity, see review in PMID 12007644 "The hexokinase 2-dependent glucose signal transduction pathway of Saccharomyces cerevisiae." Moreno F, Herrero P. After all, phosphorylated hexoses will diffuse freely in and out of the nucleus.

Caused by my ham-handed attempt to fix the flow of the writing and not be too wordy, I think. This has been clarified.

*I can't find any references in PubMed to nuclear laminins regulating apoptosis. "The progressive organisation of the nuclear lamina throughout apoptosis is used to initiate and regulate the various phases of apoptosis." TimVickers 17:56, 15 December 2006 (UTC)[reply]

Bad writing; see the revision. Lamina don't 'initiate apoptosis', but they do initiate some of the apoptotic processes within the nucleus after being cleaved by caspases, and lamin assembly failure induces apoptosis. (Not sure by which pathway this induction occurs, but that's a bit too specific here; more a matter for nuclear lamina.) Opabinia regalis 01:33, 16 December 2006 (UTC)[reply]

Support. Comprehensive, well-illustrated and clear. TimVickers 17:16, 16 December 2006 (UTC)[reply]

Comments. Quite comprehensive and well referenced. However,

Lead needs quite a bit of reworking. What is the paragraph on gene expression doing in the lead?

I believe the original point was to emphasize that only transcription occurred in the nucleus, but I think you're right that it's unnecessary; paragraph removed.

Is it possible to add a bit about the pathological conditions involving nucleii - Progeria, Anti-nuclear antibody, etc. ? Shushruth ^{\talk page \ contribs} 09:51, 17 December 2006 (UTC)[reply]

Added short descriptions of these two to the appropriate structure discussion. I don't think it's feasible to include much more than a short mention of individual disease states, as this invites indefinite expansion of an already somewhat lengthy article. Opabinia regalis 01:07, 18 December 2006 (UTC)[reply]

Support Wonderfully organized and magisterial in scope and treatment. It's written at a fittingly high level and should definitely not be simplified further; but I would include a higher density of wiki-links for the less well-read readers, e.g., phosphorylation and other freshman biochemistry concepts. Willow 12:04, 17 December 2006 (UTC)[reply]

Thanks. Few more wikilinks added - phosphorylation, snRNP, etc., especially at the beginning. Opabinia regalis 01:07, 18 December 2006 (UTC)[reply]

Support --WS 23:01, 17 December 2006 (UTC)[reply]
Support, very nice, but please fill in the missing PMIDs. I did one as I was checking to see if those journals are carried at PubMed, and will try to do more as I have time. Sandy (Talk) 06:00, 18 December 2006 (UTC)[reply]

PMIDs added. TimVickers 17:57, 18 December 2006 (UTC)[reply]

Thanks Tim! You beat me by a mile. Opabinia regalis 01:37, 19 December 2006 (UTC)[reply]