User talk:Kathyxueping/OLES2129/draft

3 April 2019 Seminar Leader: Robert Myers

Article Title: 2-acetylbutyrolactone (https://en.wikipedia.org/wiki/User:Kathyxueping/2-acetylbutyrolactone)

Associated Wikiprojects: My article could be associated with two different categories of Wikiprojects; Natural sciences and Natural sciences/Chemistry. https://en.wikipedia.org/wiki/Wikipedia:Requested_articles/Natural_sciences https://en.wikipedia.org/wiki/Wikipedia:Requested_articles/Natural_sciences/Chemistry

Brief explanation: 2-acetylbutyrolactone is the chemical compound, it has played important role in chemical and pharmacy area. As it not only can act as the material to synthesize medicine to curing narrow and wide glaucoma but also can be used to determine amine compounds. Hence, it is notable in the Wikipedia because it’s extensive application. In addition, in terms of neutrality, the physical property including the appearance, boiling point, structure and isomers, which is the 2-acetylbutyrolactone’s s unique properties. It is from scientist’s experimental analysis and observation, which guaranteed this topic is neutral in the Wikipedia. Specifically, the physical property is colourless to light and yellow in liquid. The molecular Formula is C6H803. The molecular weight is 128.127g/mol. The 2D and 3D Structure followed:

2-acetylbutyrolactone have many isomers, they thus have different names, like 4, 5-dihydro-3-acetylfuran-2(3H)-one and alpha-acetyl-gamma-butyrolactone. 2-acetylbutyrolactone not only can function as a raw material to synthesize pilocarpine but also can function as intermediate to synthesize chemical and pharmacy products. Use 2-acetylbutyrolactone to synthesize pilocarpine have far-reaching significance in history, as human derived it from the leaves of Pilocarpus jaborandi in the past, it is a great progress from natural extraction to artificial synthesis. More importantly, 2-acetylbutyrolactone could be function as a fluorogenic reagent for the determination of amine compounds. Therefore, I have chosen this topic, as its great effect on chemical and pharmacy. The synthesis of 2-acetylbutyrolactone will help people who suffered from narrow and wide glaucoma, which states its notability.

Title of sections: - The physical and chemical properties - Application of f 2-acetylbutyrolactone 1. To determine the amine compounds 2. To synthesize pilocarpine - How to synthesize 2-acetylbutyrolactone - Laboratory use safety

Source and Annotations: 2-acetylbutyrolactone. (2017). Retrieved from https://www.chemicalbook.com/ChemicalProductProperty_EN_CB8101532.htm

This source will be used in the physical and chemical section. It is a chemical book, which have guaranteed the reliability of this source. This chemical book provides detailed information about the physical and chemical property of 2-acetylbutyrolactone, like the molecular weight, boiling point and density. In terms of the chemical property, it mentioned that 2-acetylbutyrolactone is a great intermediate to involved chemical and pharmacy products. Detailed example also included, for example, use 2-acetylbutyrolactone to synthesize vitamin B, 3,4-substituted pyridine and so on. As the property content arranged as the lists, so it is easy to read. In addition, as it includes different authors for different in each section, which also increases the reliability of this resource.

Sabry, S. M. (2006). Application of 2-acetylbutyrolactone to spectrofluorimetry: Fluorescence properties of Schiff bases derived from 2-acetylbutyrolactone and spectrofluorimetric determination of primary amine-containing compounds. Journal of pharmaceutical and biomedical analysis, 40(5), 1057-1067.

This article will be used in the application of 2-acetylbutyrolactone-to determine the amine compounds section. It is from Science Direct and is the Journal of Pharmaceutical and Biomedical Analysis. Hence, it has high reliability. I have also checked the cited articles, the references have high quality, some of them is from google scholar and chemistry book. Thus, it is verifiable. This article has detailed information for how to use 2-acetylbutyrolactone to determine amine compounds. And even included the reaction. In this article, it has offered two possible ways. Firstly, 2-acetylbutyrolactone reacted with SMX to form 2-[1-(4-substituted pheylimino) ethyl]-r-butyrolactone. Initially, it is the Schiff base and then become yellow fluorescent compound. Secondly, 2-acetylbutyrolactone reacted with ampicillin sodium. Ampicillin sodium’s α-amino group of the chain reacted with 2-acetylbutyrolactone’s reactive carbon group, forming Schiff base. One-point value to mention is that this article has analyzed the factors may affected the reaction from different angles. Hence, adding the reliability for this article.

Horne, D., Fugmann, B., Yakushijin, K., & Buchi, G. (2019). A synthesis of pilocarpine. This article will be used in the application of 2-acetylbutyrolactone- to synthesize pilocarpine section. This source is from ACS Publications (Most Trusted, Most Cited, Most Read.) It is the journal of Organic Chemistry. The cited reference is J.Org.Chem. Hence, it is reliable and verifiable. This article has stated the development of curing narrow and wide glaucoma. It is first derived from the leaves of Pilocarpus jaborandi. Such type of the tree only grow in tropical area in Brazil and Paraguay. The demands of such type of tree to cure glaucoma almost caused the extinct of this tree. This article even included the experimental method. Use acetylbutenolide to synthesis pilocarpine have four stages, one of the key process is to synthesize unsaturated acetylbutyrolactone from 2-acetylbutyrolactone. In this process, 2-acetylbutyrolactone is functioned as an important raw material. Therefore, this article will be beneficial and reliable, due to the its publications and its references.

α-Acetylbutyrolactone 517-23-7 Route Of Synthesis _ Synthetic Routes. (2019). Retrieved fromhttps://www.google.com.au/search?client=opera&q=How+to+synthesize+2-acetylbutyrolactone&sourceid=opera&ie=UTF-8&oe=UTF-8 This source will be used in how to synthesize 2-acetylbutyrolactone section. It is from Molbase and it is east to verify it. This mold data has offered 13 synthesis routes, and has detailed reaction, even offered the yield. The highest yield is using oxirane react with methyl acetoacetate to synthesize 2-acetylbutyrolactone. Hence, the explanation is detailed and verifiable. It offers the reliable reference for each possible routes, like the journal and textbook. These references making these 15 possible routes for synthesize 2-acetylbutyrolactone become more reliable.

(2019). Retrieved from https://www.fishersci.com/store/msds?partNumber=AC102490010&productDescription=2-ACETYLBUTYROLACTONE+9+1LT2-&vendorId=VN00032119&countryCode=US&language=en This source will be used in laboratory use safety section. It is from the ThermoFisher, which is a scientific company. The main reason I use this source is mainly because it have given detailed safety datasheet. This data sheet has mentioned 2-acetylbutyrolactone identification, hazard identification like the precautionary statements for the different situations. Even include the first-aid measures for the different conditions, like eye contact, skin contact, inhalation and ingestion. I do think this parts is really important, as the laboratory section requirements. For a chemical compounds, it is important to have the laboratory section, for the laboratory section, it significant to include the safety use section. Hence, this source is necessary. It has also mentioned handling and storage for this compounds. This safety datasheet is notability, as its clear arrangement and detailed information. All the aspects have included for safety using 2-acetylbutyrolactone in the laboratory. Kathyxueping (talk) 05:30, 3 April 2019 (UTC)[reply]