Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 01:49, 8 November 2007 (UTC)
Proteins without matches (18)
Proteins with a High Potential Match (7)
Created (4)
Manual Inspection (Page not found) (21)
Protein Status Grid - Date: 01:49, 8 November 2007 (UTC)
Vebose Log - Date: 01:49, 8 November 2007 (UTC)
- INFO: Beginning work on ATP1A1... {November 7, 2007 5:17:19 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ATP1A1 image.jpg {November 7, 2007 5:17:54 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:18:06 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ATP1A1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mo7.
| PDB = {{PDB2|1mo7}}, {{PDB2|1mo8}}
| Name = ATPase, Na+/K+ transporting, alpha 1 polypeptide
| HGNCid = 799
| Symbol = ATP1A1
| AltSymbols =; MGC3285; MGC51750
| OMIM = 182310
| ECnumber =
| Homologene = 564
| MGIid = 88105
| GeneAtlas_image1 = PBB_GE_ATP1A1_220948_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003869 |text = 4-nitrophenylphosphatase activity}} {{GNF_GO|id=GO:0005391 |text = sodium:potassium-exchanging ATPase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015077 |text = monovalent inorganic cation transmembrane transporter activity}} {{GNF_GO|id=GO:0015662 |text = ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016820 |text = hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005890 |text = sodium:potassium-exchanging ATPase complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}} {{GNF_GO|id=GO:0042383 |text = sarcolemma}}
| Process = {{GNF_GO|id=GO:0002026 |text = cardiac inotropy}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0015991 |text = ATP hydrolysis coupled proton transport}} {{GNF_GO|id=GO:0030317 |text = sperm motility}} {{GNF_GO|id=GO:0030641 |text = cellular hydrogen ion homeostasis}} {{GNF_GO|id=GO:0045822 |text = negative regulation of heart contraction}} {{GNF_GO|id=GO:0045823 |text = positive regulation of heart contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 476
| Hs_Ensembl = ENSG00000163399
| Hs_RefseqProtein = NP_000692
| Hs_RefseqmRNA = NM_000701
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 116717359
| Hs_GenLoc_end = 116754301
| Hs_Uniprot = P05023
| Mm_EntrezGene = 11928
| Mm_Ensembl = ENSMUSG00000033161
| Mm_RefseqmRNA = NM_144900
| Mm_RefseqProtein = NP_659149
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 101705286
| Mm_GenLoc_end = 101733745
| Mm_Uniprot = Q3TXF9
}}
}}
'''ATPase, Na+/K+ transporting, alpha 1 polypeptide''', also known as '''ATP1A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=476| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lingrel JB, Orlowski J, Shull MM, Price EM |title=Molecular genetics of Na,K-ATPase. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=38 |issue= |pages= 37-89 |year= 1990 |pmid= 2158121 |doi= }}
*{{cite journal | author=Dunbar LA, Caplan MJ |title=Ion pumps in polarized cells: sorting and regulation of the Na+, K+- and H+, K+-ATPases. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 29617-20 |year= 2001 |pmid= 11404365 |doi= 10.1074/jbc.R100023200 }}
*{{cite journal | author=Wangemann P |title=K+ cycling and the endocochlear potential. |journal=Hear. Res. |volume=165 |issue= 1-2 |pages= 1-9 |year= 2002 |pmid= 12031509 |doi= }}
*{{cite journal | author=Xie Z, Cai T |title=Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function. |journal=Mol. Interv. |volume=3 |issue= 3 |pages= 157-68 |year= 2004 |pmid= 14993422 |doi= 10.1124/mi.3.3.157 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on C4A... {November 7, 2007 5:18:06 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:19:21 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_C4A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hzf.
| PDB = {{PDB2|1hzf}}
| Name = Complement component 4A (Rodgers blood group)
| HGNCid = 1323
| Symbol = C4A
| AltSymbols =; C4; C4A2; C4A3; C4A4; C4A6; C4B; C4S; CO4; CPAMD2; RG; C4A; C4A13; C4A91; C4B1; C4B12; C4B2; C4B3; C4B5; C4F; CH; CPAMD3
| OMIM = 120810
| ECnumber =
| Homologene = 36030
| MGIid = 88228
| GeneAtlas_image1 = PBB_GE_C4A_208451_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_C4A_214428_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004866 |text = endopeptidase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006956 |text = complement activation}} {{GNF_GO|id=GO:0006958 |text = complement activation, classical pathway}} {{GNF_GO|id=GO:0045087 |text = innate immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 720
| Hs_Ensembl = ENSG00000204319
| Hs_RefseqProtein = NP_009224
| Hs_RefseqmRNA = NM_007293
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 32090517
| Hs_GenLoc_end = 32111174
| Hs_Uniprot = P0C0L4
| Mm_EntrezGene = 12268
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_001002697
| Mm_RefseqProtein = XP_001002697
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Complement component 4A (Rodgers blood group)''', also known as '''C4A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.<ref>{{cite web | title = Entrez Gene: C4A complement component 4A (Rodgers blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=720| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hugli TE |title=Biochemistry and biology of anaphylatoxins. |journal=Complement |volume=3 |issue= 3 |pages= 111-27 |year= 1987 |pmid= 3542363 |doi= }}
*{{cite journal | author=Yu CY |title=Molecular genetics of the human MHC complement gene cluster. |journal=Exp. Clin. Immunogenet. |volume=15 |issue= 4 |pages= 213-30 |year= 1999 |pmid= 10072631 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CALM3... {November 7, 2007 5:19:21 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CALM3 image.jpg {November 7, 2007 5:19:40 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 5:19:53 PM PST}
- CREATED: Created new protein page: CALM3 {November 7, 2007 5:20:01 PM PST}
- INFO: Beginning work on CD82... {November 7, 2007 5:25:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:26:44 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD82 molecule
| HGNCid = 6210
| Symbol = CD82
| AltSymbols =; R2; IA4; 4F9; C33; GR15; KAI1; SAR2; ST6; TSPAN27
| OMIM = 600623
| ECnumber =
| Homologene = 20512
| MGIid = 104651
| GeneAtlas_image1 = PBB_GE_CD82_203904_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3732
| Hs_Ensembl = ENSG00000085117
| Hs_RefseqProtein = NP_001020015
| Hs_RefseqmRNA = NM_001024844
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 44543717
| Hs_GenLoc_end = 44597889
| Hs_Uniprot = P27701
| Mm_EntrezGene = 12521
| Mm_Ensembl = ENSMUSG00000027215
| Mm_RefseqmRNA = NM_007656
| Mm_RefseqProtein = NP_031682
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 93219950
| Mm_GenLoc_end = 93263335
| Mm_Uniprot = Q3UII2
}}
}}
'''CD82 molecule''', also known as '''CD82''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: CD82 CD82 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3732| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Baek SH |title=A novel link between SUMO modification and cancer metastasis. |journal=Cell Cycle |volume=5 |issue= 14 |pages= 1492-5 |year= 2006 |pmid= 16861889 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on EZH2... {November 7, 2007 5:20:01 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 5:20:38 PM PST}
- CREATED: Created new protein page: EZH2 {November 7, 2007 5:20:45 PM PST}
- INFO: Beginning work on FCER2... {November 7, 2007 5:20:45 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein FCER2 image.jpg {November 7, 2007 5:21:36 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:22:00 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FCER2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1t8c.
| PDB = {{PDB2|1t8c}}, {{PDB2|1t8d}}, {{PDB2|2h2r}}, {{PDB2|2h2t}}
| Name = Fc fragment of IgE, low affinity II, receptor for (CD23)
| HGNCid = 3612
| Symbol = FCER2
| AltSymbols =; CD23; CD23A; CLEC4J; FCE2; IGEBF
| OMIM = 151445
| ECnumber =
| Homologene = 1517
| MGIid = 95497
| GeneAtlas_image1 = PBB_GE_FCER2_206760_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FCER2_206759_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0005178 |text = integrin binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} {{GNF_GO|id=GO:0019863 |text = IgE binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2208
| Hs_Ensembl = ENSG00000104921
| Hs_RefseqProtein = NP_001993
| Hs_RefseqmRNA = NM_002002
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 7659667
| Hs_GenLoc_end = 7673032
| Hs_Uniprot = P06734
| Mm_EntrezGene = 14128
| Mm_Ensembl = ENSMUSG00000005540
| Mm_RefseqmRNA = NM_013517
| Mm_RefseqProtein = NP_038545
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 3681801
| Mm_GenLoc_end = 3694174
| Mm_Uniprot = P20693
}}
}}
'''Fc fragment of IgE, low affinity II, receptor for (CD23)''', also known as '''FCER2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The human leukocyte differentiation antigen CD23 (FCE2) is a key molecule for B-cell activation and growth. It is the low-affinity receptor for IgE. The truncated molecule can be secreted, then functioning as a potent mitogenic growth factor.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2208| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kijimoto-Ochiai S |title=CD23 (the low-affinity IgE receptor) as a C-type lectin: a multidomain and multifunctional molecule. |journal=Cell. Mol. Life Sci. |volume=59 |issue= 4 |pages= 648-64 |year= 2002 |pmid= 12022472 |doi= }}
*{{cite journal | author=Schwarzmeier JD, Hubmann R, Düchler M, ''et al.'' |title=Regulation of CD23 expression by Notch2 in B-cell chronic lymphocytic leukemia. |journal=Leuk. Lymphoma |volume=46 |issue= 2 |pages= 157-65 |year= 2005 |pmid= 15621797 |doi= 10.1080/10428190400010742 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HLA-DRB3... {November 7, 2007 5:22:00 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HLA-DRB3 image.jpg {November 7, 2007 5:23:04 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:23:17 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HLA-DRB3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a6a.
| PDB = {{PDB2|1a6a}}, {{PDB2|1d5m}}, {{PDB2|1d5x}}, {{PDB2|1d5z}}, {{PDB2|1d6e}}, {{PDB2|1j8h}}, {{PDB2|2seb}}
| Name = Major histocompatibility complex, class II, DR beta 3
| HGNCid = 4951
| Symbol = HLA-DRB3
| AltSymbols =; HLA-DR3B; MGC117330
| OMIM =
| ECnumber =
| Homologene =
| MGIid =
| GeneAtlas_image1 = PBB_GE_HLA-DRB3_209312_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_HLA-DRB3_215193_x_at_tn.png
| Function = {{GNF_GO|id=GO:0032395 |text = MHC class II receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042613 |text = MHC class II protein complex}}
| Process = {{GNF_GO|id=GO:0002504 |text = antigen processing and presentation of peptide or polysaccharide antigen via MHC class II}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3125
| Hs_Ensembl = ENSG00000206241
| Hs_RefseqProtein = NP_072049
| Hs_RefseqmRNA = NM_022555
| Hs_GenLoc_db =
| Hs_GenLoc_chr = c6_COX
| Hs_GenLoc_start = 32560298
| Hs_GenLoc_end = 32572205
| Hs_Uniprot = P79483
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Major histocompatibility complex, class II, DR beta 3''', also known as '''HLA-DRB3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.<ref>{{cite web | title = Entrez Gene: HLA-DRB3 major histocompatibility complex, class II, DR beta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3125| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Germain RN |title=Binding domain regulation of MHC class II molecule assembly, trafficking, fate, and function. |journal=Semin. Immunol. |volume=7 |issue= 6 |pages= 361-72 |year= 1996 |pmid= 8775462 |doi= 10.1006/smim.1995.0041 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HSPG2... {November 7, 2007 5:23:17 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HSPG2 image.jpg {November 7, 2007 5:24:08 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:24:25 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HSPG2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gl4.
| PDB = {{PDB2|1gl4}}
| Name = Heparan sulfate proteoglycan 2
| HGNCid = 5273
| Symbol = HSPG2
| AltSymbols =; PLC; PRCAN; SJA; SJS; SJS1
| OMIM = 142461
| ECnumber =
| Homologene = 68473
| MGIid =
| GeneAtlas_image1 = PBB_GE_HSPG2_201655_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HSPG2_201654_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005604 |text = basement membrane}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0008104 |text = protein localization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3339
| Hs_Ensembl = ENSG00000142798
| Hs_RefseqProtein = NP_005520
| Hs_RefseqmRNA = NM_005529
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 22021325
| Hs_GenLoc_end = 22136377
| Hs_Uniprot = P98160
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Heparan sulfate proteoglycan 2''', also known as '''HSPG2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Heparan sulfate proteoglycan is a major component of basement membranes, where the molecule may be involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. This form of HSPG, known as HSPG2 or perlecan, is encoded by a gene that maps to chromosome 1. The gene for the form of HSPG associated with the cell surface of fibroblasts has been mapped to human chromosome 8 (MIM 142460).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: HSPG2 heparan sulfate proteoglycan 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3339| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Olsen BR |title=Life without perlecan has its problems. |journal=J. Cell Biol. |volume=147 |issue= 5 |pages= 909-12 |year= 1999 |pmid= 10579711 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on IL12A... {November 7, 2007 5:25:13 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein IL12A image.jpg {November 7, 2007 5:25:28 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 5:25:45 PM PST}
- CREATED: Created new protein page: IL12A {November 7, 2007 5:25:52 PM PST}
- INFO: Beginning work on IL2RG... {November 7, 2007 5:24:25 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein IL2RG image.jpg {November 7, 2007 5:24:56 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:25:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_IL2RG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2b5i.
| PDB = {{PDB2|2b5i}}, {{PDB2|2erj}}
| Name = Interleukin 2 receptor, gamma (severe combined immunodeficiency)
| HGNCid = 6010
| Symbol = IL2RG
| AltSymbols =; CD132; IMD4; SCIDX; SCIDX1
| OMIM = 308380
| ECnumber =
| Homologene = 172
| MGIid = 96551
| GeneAtlas_image1 = PBB_GE_IL2RG_204116_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004896 |text = hematopoietin/interferon-class (D200-domain) cytokine receptor activity}} {{GNF_GO|id=GO:0004911 |text = interleukin-2 receptor activity}} {{GNF_GO|id=GO:0004913 |text = interleukin-4 receptor activity}} {{GNF_GO|id=GO:0004917 |text = interleukin-7 receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3561
| Hs_Ensembl = ENSG00000147168
| Hs_RefseqProtein = NP_000197
| Hs_RefseqmRNA = NM_000206
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 70243979
| Hs_GenLoc_end = 70248188
| Hs_Uniprot = P31785
| Mm_EntrezGene = 16186
| Mm_Ensembl = ENSMUSG00000031304
| Mm_RefseqmRNA = NM_013563
| Mm_RefseqProtein = NP_038591
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 97467097
| Mm_GenLoc_end = 97470925
| Mm_Uniprot = Q3UPA9
}}
}}
'''Interleukin 2 receptor, gamma (severe combined immunodeficiency)''', also known as '''IL2RG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The interleukin 2 (IL2) receptor gamma chain (IL2RG), an important signalling component of many interleukin receptors (IL2,IL4,IL7,IL9, and IL15), is thus referred to as the common gamma chain. Mutations in this X-chromosome-linked gene cause X-linked severe combined immunodeficiency (XSCID).<ref>{{cite web | title = Entrez Gene: IL2RG interleukin 2 receptor, gamma (severe combined immunodeficiency)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3561| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ellery JM, Nicholls PJ |title=Alternate signalling pathways from the interleukin-2 receptor. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 1 |pages= 27-40 |year= 2002 |pmid= 11750878 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KCNJ2... {November 7, 2007 5:26:44 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein KCNJ2 image.jpg {November 7, 2007 5:27:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:27:37 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_KCNJ2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1u4f.
| PDB = {{PDB2|1u4f}}, {{PDB2|2gix}}
| Name = Potassium inwardly-rectifying channel, subfamily J, member 2
| HGNCid = 6263
| Symbol = KCNJ2
| AltSymbols =; HHBIRK1; HHIRK1; IRK1; KIR2.1; LQT7; SQT3
| OMIM = 600681
| ECnumber =
| Homologene = 20249
| MGIid = 104744
| GeneAtlas_image1 = PBB_GE_KCNJ2_206765_at_tn.png
| Function = {{GNF_GO|id=GO:0005242 |text = inward rectifier potassium channel activity}} {{GNF_GO|id=GO:0005244 |text = voltage-gated ion channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3759
| Hs_Ensembl = ENSG00000123700
| Hs_RefseqProtein = NP_000882
| Hs_RefseqmRNA = NM_000891
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 65677271
| Hs_GenLoc_end = 65687755
| Hs_Uniprot = P63252
| Mm_EntrezGene = 16518
| Mm_Ensembl = ENSMUSG00000041695
| Mm_RefseqmRNA = NM_008425
| Mm_RefseqProtein = NP_032451
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 110882254
| Mm_GenLoc_end = 110891741
| Mm_Uniprot = Q543W5
}}
}}
'''Potassium inwardly-rectifying channel, subfamily J, member 2''', also known as '''KCNJ2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features.<ref>{{cite web | title = Entrez Gene: KCNJ2 potassium inwardly-rectifying channel, subfamily J, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3759| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kubo Y, Adelman JP, Clapham DE, ''et al.'' |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509-26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on KRT14... {November 7, 2007 5:27:37 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:28:25 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)
| HGNCid = 6416
| Symbol = KRT14
| AltSymbols =; CK14; EBS3; EBS4; K14
| OMIM = 148066
| ECnumber =
| Homologene = 81522
| MGIid = 96688
| GeneAtlas_image1 = PBB_GE_KRT14_209351_at_tn.png
| Function = {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030280 |text = structural constituent of epidermis}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005882 |text = intermediate filament}} {{GNF_GO|id=GO:0045095 |text = keratin filament}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0008544 |text = epidermis development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3861
| Hs_Ensembl = ENSG00000186847
| Hs_RefseqProtein = NP_000517
| Hs_RefseqmRNA = NM_000526
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 36992070
| Hs_GenLoc_end = 36996699
| Hs_Uniprot = P02533
| Mm_EntrezGene = 16664
| Mm_Ensembl = ENSMUSG00000045545
| Mm_RefseqmRNA = NM_016958
| Mm_RefseqProtein = NP_058654
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 100019252
| Mm_GenLoc_end = 100023600
| Mm_Uniprot = Q61782
}}
}}
'''Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)''', also known as '''KRT14''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11.<ref>{{cite web | title = Entrez Gene: KRT14 keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3861| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schuilenga-Hut PH, Vlies P, Jonkman MF, ''et al.'' |title=Mutation analysis of the entire keratin 5 and 14 genes in patients with epidermolysis bullosa simplex and identification of novel mutations. |journal=Hum. Mutat. |volume=21 |issue= 4 |pages= 447 |year= 2003 |pmid= 12655565 |doi= 10.1002/humu.9124 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LIF... {November 7, 2007 5:28:25 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein LIF image.jpg {November 7, 2007 5:29:05 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:29:20 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LIF_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1emr.
| PDB = {{PDB2|1emr}}, {{PDB2|1pvh}}
| Name = Leukemia inhibitory factor (cholinergic differentiation factor)
| HGNCid = 6596
| Symbol = LIF
| AltSymbols =; CDF; D-FACTOR; HILDA
| OMIM = 159540
| ECnumber =
| Homologene = 1734
| MGIid = 96787
| GeneAtlas_image1 = PBB_GE_LIF_205266_at_tn.png
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005146 |text = leukemia inhibitory factor receptor binding}} {{GNF_GO|id=GO:0005147 |text = oncostatin-M receptor binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0042503 |text = tyrosine phosphorylation of Stat3 protein}} {{GNF_GO|id=GO:0048644 |text = muscle morphogenesis}} {{GNF_GO|id=GO:0048666 |text = neuron development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3976
| Hs_Ensembl = ENSG00000128342
| Hs_RefseqProtein = NP_002300
| Hs_RefseqmRNA = NM_002309
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 28966441
| Hs_GenLoc_end = 28972748
| Hs_Uniprot = P15018
| Mm_EntrezGene = 16878
| Mm_Ensembl = ENSMUSG00000034394
| Mm_RefseqmRNA = NM_001039537
| Mm_RefseqProtein = NP_001034626
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 4157571
| Mm_GenLoc_end = 4172517
| Mm_Uniprot = Q3U1H5
}}
}}
'''Leukemia inhibitory factor (cholinergic differentiation factor)''', also known as '''LIF''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Leukaemia inhibitory factor is a cytokine that induces macrophage differentiation. Neurotransmitters and neuropeptides, well known for their role in the communication between neurons, are also capable of activating monocytes and macrophages and inducing chemotaxis in immune cells. LIF signals through different receptors and transcription factors. LIF in conjunction with BMP2 acts in synergy on primary fetal neural progenitor cells to induce astrocytes.<ref>{{cite web | title = Entrez Gene: LIF leukemia inhibitory factor (cholinergic differentiation factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3976| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Patterson PH |title=Leukemia inhibitory factor, a cytokine at the interface between neurobiology and immunology. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 17 |pages= 7833-5 |year= 1994 |pmid= 8058719 |doi= }}
*{{cite journal | author=Aghajanova L |title=Leukemia inhibitory factor and human embryo implantation. |journal=Ann. N. Y. Acad. Sci. |volume=1034 |issue= |pages= 176-83 |year= 2005 |pmid= 15731310 |doi= 10.1196/annals.1335.020 }}
*{{cite journal | author=Králícková M, Síma P, Rokyta Z |title=Role of the leukemia-inhibitory factor gene mutations in infertile women: the embryo-endometrial cytokine cross talk during implantation--a delicate homeostatic equilibrium. |journal=Folia Microbiol. (Praha) |volume=50 |issue= 3 |pages= 179-86 |year= 2005 |pmid= 16295654 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LIPE... {November 7, 2007 5:29:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:30:52 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Lipase, hormone-sensitive
| HGNCid = 6621
| Symbol = LIPE
| AltSymbols =; HSL; LHS
| OMIM = 151750
| ECnumber =
| Homologene = 3912
| MGIid = 96790
| GeneAtlas_image1 = PBB_GE_LIPE_208186_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_LIPE_213855_s_at_tn.png
| Function = {{GNF_GO|id=GO:0016788 |text = hydrolase activity, acting on ester bonds}} {{GNF_GO|id=GO:0047372 |text = acylglycerol lipase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006631 |text = fatty acid metabolic process}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}} {{GNF_GO|id=GO:0008203 |text = cholesterol metabolic process}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}} {{GNF_GO|id=GO:0019433 |text = triacylglycerol catabolic process}} {{GNF_GO|id=GO:0042493 |text = response to drug}} {{GNF_GO|id=GO:0046340 |text = diacylglycerol catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3991
| Hs_Ensembl = ENSG00000079435
| Hs_RefseqProtein = NP_005348
| Hs_RefseqmRNA = NM_005357
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 47597499
| Hs_GenLoc_end = 47623418
| Hs_Uniprot = Q05469
| Mm_EntrezGene = 16890
| Mm_Ensembl = ENSMUSG00000003123
| Mm_RefseqmRNA = NM_001039507
| Mm_RefseqProtein = NP_001034596
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 25088287
| Mm_GenLoc_end = 25104747
| Mm_Uniprot = Q6LCY9
}}
}}
'''Lipase, hormone-sensitive''', also known as '''LIPE''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids.<ref>{{cite web | title = Entrez Gene: LIPE lipase, hormone-sensitive| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3991| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LPA... {November 7, 2007 5:30:52 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein LPA image.jpg {November 7, 2007 5:31:41 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:31:55 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LPA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1i71.
| PDB = {{PDB2|1i71}}, {{PDB2|1jfn}}, {{PDB2|1kiv}}, {{PDB2|2feb}}, {{PDB2|3kiv}}, {{PDB2|4kiv}}
| Name = Lipoprotein, Lp(a)
| HGNCid = 6667
| Symbol = LPA
| AltSymbols =; AK38; APOA; LP
| OMIM = 152200
| ECnumber =
| Homologene = 87856
| MGIid =
| GeneAtlas_image1 = PBB_GE_LPA_207584_at_tn.png
| GeneAtlas_image2 = PBB_GE_LPA_209978_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0004866 |text = endopeptidase inhibitor activity}} {{GNF_GO|id=GO:0005319 |text = lipid transporter activity}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006869 |text = lipid transport}} {{GNF_GO|id=GO:0008015 |text = circulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4018
| Hs_Ensembl = ENSG00000198670
| Hs_RefseqProtein = XP_946885
| Hs_RefseqmRNA = XM_941792
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 160872505
| Hs_GenLoc_end = 161005281
| Hs_Uniprot = P08519
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Lipoprotein, Lp(a)''', also known as '''LPA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Utermann G |title=The mysteries of lipoprotein(a). |journal=Science |volume=246 |issue= 4932 |pages= 904-10 |year= 1989 |pmid= 2530631 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LRP5... {November 7, 2007 5:31:55 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:32:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Low density lipoprotein receptor-related protein 5
| HGNCid = 6697
| Symbol = LRP5
| AltSymbols =; HBM; BMND1; EVR1; EVR4; LR3; LRP7; OPPG; OPS; OPTA1; VBCH2
| OMIM = 603506
| ECnumber =
| Homologene = 1746
| MGIid = 1278315
| GeneAtlas_image1 = PBB_GE_LRP5_209468_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4041
| Hs_Ensembl = ENSG00000162337
| Hs_RefseqProtein = NP_002326
| Hs_RefseqmRNA = NM_002335
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 67836674
| Hs_GenLoc_end = 67973301
| Hs_Uniprot = O75197
| Mm_EntrezGene = 16973
| Mm_Ensembl = ENSMUSG00000024913
| Mm_RefseqmRNA = NM_008513
| Mm_RefseqProtein = NP_032539
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 3584836
| Mm_GenLoc_end = 3686546
| Mm_Uniprot = Q3UI55
}}
}}
'''Low density lipoprotein receptor-related protein 5''', also known as '''LRP5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=He X, Semenov M, Tamai K, Zeng X |title=LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. |journal=Development |volume=131 |issue= 8 |pages= 1663-77 |year= 2004 |pmid= 15084453 |doi= 10.1242/dev.01117 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MX1... {November 7, 2007 5:32:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:33:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
| HGNCid = 7532
| Symbol = MX1
| AltSymbols =; IFI-78K; IFI78; MX; MxA
| OMIM = 147150
| ECnumber =
| Homologene = 1844
| MGIid = 97244
| GeneAtlas_image1 = PBB_GE_MX1_202086_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0009615 |text = response to virus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4599
| Hs_Ensembl = ENSG00000157601
| Hs_RefseqProtein = NP_002453
| Hs_RefseqmRNA = NM_002462
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 41725838
| Hs_GenLoc_end = 41753008
| Hs_Uniprot = P20591
| Mm_EntrezGene = 17858
| Mm_Ensembl = ENSMUSG00000023341
| Mm_RefseqmRNA = NM_013606
| Mm_RefseqProtein = NP_038634
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 97690999
| Mm_GenLoc_end = 97715817
| Mm_Uniprot = Q61924
}}
}}
'''Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)''', also known as '''MX1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the family of large GTPases.<ref>{{cite web | title = Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4599| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NDRG1... {November 7, 2007 5:38:47 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:39:41 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = N-myc downstream regulated gene 1
| HGNCid = 7679
| Symbol = NDRG1
| AltSymbols =; DRG1; CAP43; CMT4D; GC4; HMSNL; NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5
| OMIM = 605262
| ECnumber =
| Homologene = 55953
| MGIid = 1341799
| GeneAtlas_image1 = PBB_GE_NDRG1_200632_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0010038 |text = response to metal ion}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10397
| Hs_Ensembl = ENSG00000104419
| Hs_RefseqProtein = NP_006087
| Hs_RefseqmRNA = NM_006096
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 134318601
| Hs_GenLoc_end = 134379011
| Hs_Uniprot = Q92597
| Mm_EntrezGene = 17988
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_008681
| Mm_RefseqProtein = NP_032707
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''N-myc downstream regulated gene 1''', also known as '''NDRG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom.<ref>{{cite web | title = Entrez Gene: NDRG1 N-myc downstream regulated gene 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10397| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kovacevic Z, Richardson DR |title=The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer. |journal=Carcinogenesis |volume=27 |issue= 12 |pages= 2355-66 |year= 2007 |pmid= 16920733 |doi= 10.1093/carcin/bgl146 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NMT1... {November 7, 2007 5:33:27 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NMT1 image.jpg {November 7, 2007 5:34:42 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:34:54 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NMT1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1rxt.
| PDB = {{PDB2|1rxt}}
| Name = N-myristoyltransferase 1
| HGNCid = 7857
| Symbol = NMT1
| AltSymbols =; NMT
| OMIM = 160993
| ECnumber =
| Homologene = 69027
| MGIid = 102579
| GeneAtlas_image1 = PBB_GE_NMT1_201157_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NMT1_201158_at_tn.png
| GeneAtlas_image3 = PBB_GE_NMT1_201159_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004379 |text = glycylpeptide N-tetradecanoyltransferase activity}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0006498 |text = N-terminal protein lipidation}} {{GNF_GO|id=GO:0006499 |text = N-terminal protein myristoylation}} {{GNF_GO|id=GO:0009249 |text = protein lipoylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4836
| Hs_Ensembl = ENSG00000136448
| Hs_RefseqProtein = NP_066565
| Hs_RefseqmRNA = NM_021079
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 40494206
| Hs_GenLoc_end = 40541903
| Hs_Uniprot = P30419
| Mm_EntrezGene = 18107
| Mm_Ensembl = ENSMUSG00000020936
| Mm_RefseqmRNA = XM_906274
| Mm_RefseqProtein = XP_911367
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 102844436
| Mm_GenLoc_end = 102885002
| Mm_Uniprot = Q3UJC3
}}
}}
'''N-myristoyltransferase 1''', also known as '''NMT1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Rajala RV, Datla RS, Moyana TN, ''et al.'' |title=N-myristoyltransferase. |journal=Mol. Cell. Biochem. |volume=204 |issue= 1-2 |pages= 135-55 |year= 2000 |pmid= 10718634 |doi= }}
*{{cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580-5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NR1H3... {November 7, 2007 5:37:54 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NR1H3 image.jpg {November 7, 2007 5:38:27 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 5:38:41 PM PST}
- CREATED: Created new protein page: NR1H3 {November 7, 2007 5:38:47 PM PST}
- INFO: Beginning work on OCLN... {November 7, 2007 5:34:54 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein OCLN image.jpg {November 7, 2007 5:35:06 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:35:14 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_OCLN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wpa.
| PDB = {{PDB2|1wpa}}, {{PDB2|1xaw}}
| Name = Occludin
| HGNCid = 8104
| Symbol = OCLN
| AltSymbols =;
| OMIM = 602876
| ECnumber =
| Homologene = 1905
| MGIid = 106183
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005923 |text = tight junction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4950
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001128133
| Hs_RefseqmRNA = XM_001128133
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 18260
| Mm_Ensembl = ENSMUSG00000021638
| Mm_RefseqmRNA = NM_008756
| Mm_RefseqProtein = NP_032782
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 101597574
| Mm_GenLoc_end = 101652864
| Mm_Uniprot = Q3UKZ5
}}
}}
'''Occludin''', also known as '''OCLN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an integral membrane protein which is located at tight junctions. This protein may be involved in the formation and maintenance of the tight junction. The possibility of several alternatively spliced products has been suggested but the full nature of these products has not been described.<ref>{{cite web | title = Entrez Gene: OCLN occludin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4950| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PKN1... {November 7, 2007 5:35:15 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PKN1 image.jpg {November 7, 2007 5:35:54 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:36:15 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PKN1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cxz.
| PDB = {{PDB2|1cxz}}, {{PDB2|1urf}}
| Name = Protein kinase N1
| HGNCid = 9405
| Symbol = PKN1
| AltSymbols =; PAK1; DBK; MGC46204; PKN; PRK1; PRKCL1
| OMIM = 601032
| ECnumber =
| Homologene = 48130
| MGIid = 108022
| GeneAtlas_image1 = PBB_GE_PKN1_202161_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007257 |text = activation of JNK activity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5585
| Hs_Ensembl = ENSG00000123143
| Hs_RefseqProtein = NP_002732
| Hs_RefseqmRNA = NM_002741
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 14405135
| Hs_GenLoc_end = 14443678
| Hs_Uniprot = Q16512
| Mm_EntrezGene = 320795
| Mm_Ensembl = ENSMUSG00000057672
| Mm_RefseqmRNA = NM_177262
| Mm_RefseqProtein = NP_796236
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 86560199
| Mm_GenLoc_end = 86589231
| Mm_Uniprot = P70268
}}
}}
'''Protein kinase N1''', also known as '''PKN1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.<ref>{{cite web | title = Entrez Gene: PKN1 protein kinase N1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5585| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RTN4... {November 7, 2007 5:39:41 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RTN4 image.jpg {November 7, 2007 5:40:49 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:41:25 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RTN4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2g31.
| PDB = {{PDB2|2g31}}
| Name = Reticulon 4
| HGNCid = 14085
| Symbol = RTN4
| AltSymbols =; NSP; ASY; NI220/250; NOGO; NOGO-A; NSP-CL; Nbla00271; Nbla10545; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C
| OMIM = 604475
| ECnumber =
| Homologene = 10743
| MGIid = 1915835
| GeneAtlas_image1 = PBB_GE_RTN4_211509_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RTN4_210968_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RTN4_214629_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030176 |text = integral to endoplasmic reticulum membrane}}
| Process = {{GNF_GO|id=GO:0019987 |text = negative regulation of anti-apoptosis}} {{GNF_GO|id=GO:0030517 |text = negative regulation of axon extension}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 57142
| Hs_Ensembl = ENSG00000115310
| Hs_RefseqProtein = NP_008939
| Hs_RefseqmRNA = NM_007008
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 55052829
| Hs_GenLoc_end = 55131468
| Hs_Uniprot = Q9NQC3
| Mm_EntrezGene = 68585
| Mm_Ensembl = ENSMUSG00000020458
| Mm_RefseqmRNA = NM_024226
| Mm_RefseqProtein = NP_077188
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 29592947
| Mm_GenLoc_end = 29644255
| Mm_Uniprot = Q99P72
}}
}}
'''Reticulon 4''', also known as '''RTN4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: RTN4 reticulon 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57142| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ng CE, Tang BL |title=Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration. |journal=J. Neurosci. Res. |volume=67 |issue= 5 |pages= 559-65 |year= 2002 |pmid= 11891768 |doi= }}
*{{cite journal | author=Watari A, Yutsudo M |title=Multi-functional gene ASY/Nogo/RTN-X/RTN4: apoptosis, tumor suppression, and inhibition of neuronal regeneration. |journal=Apoptosis |volume=8 |issue= 1 |pages= 5-9 |year= 2003 |pmid= 12510146 |doi= }}
*{{cite journal | author=Schweigreiter R, Bandtlow CE |title=Nogo in the injured spinal cord. |journal=J. Neurotrauma |volume=23 |issue= 3-4 |pages= 384-96 |year= 2006 |pmid= 16629624 |doi= 10.1089/neu.2006.23.384 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TGM1... {November 7, 2007 5:36:15 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:36:55 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
| HGNCid = 11777
| Symbol = TGM1
| AltSymbols =; ICR2; KTG; LI; LI1; TGASE; TGK
| OMIM = 190195
| ECnumber =
| Homologene = 306
| MGIid = 98730
| GeneAtlas_image1 = PBB_GE_TGM1_206008_at_tn.png
| Function = {{GNF_GO|id=GO:0003810 |text = protein-glutamine gamma-glutamyltransferase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0001533 |text = cornified envelope}} {{GNF_GO|id=GO:0005913 |text = cell-cell adherens junction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0031224 |text = intrinsic to membrane}}
| Process = {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0018149 |text = peptide cross-linking}} {{GNF_GO|id=GO:0030216 |text = keratinocyte differentiation}} {{GNF_GO|id=GO:0031424 |text = keratinization}} {{GNF_GO|id=GO:0043163 |text = cell envelope organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7051
| Hs_Ensembl = ENSG00000092295
| Hs_RefseqProtein = NP_000350
| Hs_RefseqmRNA = NM_000359
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 23788162
| Hs_GenLoc_end = 23802217
| Hs_Uniprot = P22735
| Mm_EntrezGene = 21816
| Mm_Ensembl = ENSMUSG00000022218
| Mm_RefseqmRNA = NM_019984
| Mm_RefseqProtein = NP_064368
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 54654090
| Mm_GenLoc_end = 54667546
| Mm_Uniprot = Q9JLF6
}}
}}
'''Transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)''', also known as '''TGM1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE).<ref>{{cite web | title = Entrez Gene: TGM1 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7051| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TPMT... {November 7, 2007 5:36:55 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TPMT image.jpg {November 7, 2007 5:37:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 5:37:54 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TPMT_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2bzg.
| PDB = {{PDB2|2bzg}}, {{PDB2|2h11}}
| Name = Thiopurine S-methyltransferase
| HGNCid = 12014
| Symbol = TPMT
| AltSymbols =;
| OMIM = 187680
| ECnumber =
| Homologene = 313
| MGIid = 98812
| GeneAtlas_image1 = PBB_GE_TPMT_203671_at_tn.png
| GeneAtlas_image2 = PBB_GE_TPMT_203672_x_at_tn.png
| Function = {{GNF_GO|id=GO:0008119 |text = thiopurine S-methyltransferase activity}} {{GNF_GO|id=GO:0008168 |text = methyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006139 |text = nucleobase, nucleoside, nucleotide and nucleic acid metabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7172
| Hs_Ensembl = ENSG00000137364
| Hs_RefseqProtein = NP_000358
| Hs_RefseqmRNA = NM_000367
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 18236526
| Hs_GenLoc_end = 18263353
| Hs_Uniprot = P51580
| Mm_EntrezGene = 22017
| Mm_Ensembl = ENSMUSG00000021376
| Mm_RefseqmRNA = NM_016785
| Mm_RefseqProtein = NP_058065
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 47036149
| Mm_GenLoc_end = 47054175
| Mm_Uniprot = O55060
}}
}}
'''Thiopurine S-methyltransferase''', also known as '''TPMT''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.<ref>{{cite web | title = Entrez Gene: TPMT thiopurine S-methyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7172| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Krynetski EY, Tai HL, Yates CR, ''et al.'' |title=Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms. |journal=Pharmacogenetics |volume=6 |issue= 4 |pages= 279-90 |year= 1997 |pmid= 8873214 |doi= }}
*{{cite journal | author=Krynetski E, Evans WE |title=Drug methylation in cancer therapy: lessons from the TPMT polymorphism. |journal=Oncogene |volume=22 |issue= 47 |pages= 7403-13 |year= 2003 |pmid= 14576848 |doi= 10.1038/sj.onc.1206944 }}
*{{cite journal | author=Corominas H, Baiget M |title=Clinical utility of thiopurine S-methyltransferase genotyping. |journal=American journal of pharmacogenomics : genomics-related research in drug development and clinical practice |volume=4 |issue= 1 |pages= 1-8 |year= 2004 |pmid= 14987117 |doi= }}
*{{cite journal | author=Krynetskiy EY, Evans WE |title=Closing the gap between science and clinical practice: the thiopurine S-methyltransferase polymorphism moves forward. |journal=Pharmacogenetics |volume=14 |issue= 7 |pages= 395-6 |year= 2005 |pmid= 15226671 |doi= }}
*{{cite journal | author=Coulthard SA, Matheson EC, Hall AG, Hogarth LA |title=The clinical impact of thiopurine methyltransferase polymorphisms on thiopurine treatment. |journal=Nucleosides Nucleotides Nucleic Acids |volume=23 |issue= 8-9 |pages= 1385-91 |year= 2005 |pmid= 15571264 |doi= }}
*{{cite journal | author=Lee W, Lockhart AC, Kim RB, Rothenberg ML |title=Cancer pharmacogenomics: powerful tools in cancer chemotherapy and drug development. |journal=Oncologist |volume=10 |issue= 2 |pages= 104-11 |year= 2005 |pmid= 15709212 |doi= 10.1634/theoncologist.10-2-104 }}
*{{cite journal | author=Pierik M, Rutgeerts P, Vlietinck R, Vermeire S |title=Pharmacogenetics in inflammatory bowel disease. |journal=World J. Gastroenterol. |volume=12 |issue= 23 |pages= 3657-67 |year= 2006 |pmid= 16773681 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
