User:Mr. Ibrahem/Atorvastatin
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| Clinical data | |
|---|---|
| Pronunciation | /əˌtɔːrvəˈstætən/ |
| Trade names | Lipitor, Sortis, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a600045 |
| License data |
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| Pregnancy category | |
| Routes of administration | By mouth |
| Drug class | Statin |
| Legal status | |
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| Pharmacokinetic data | |
| Bioavailability | 12% |
| Metabolism | Liver (CYP3A4) |
| Elimination half-life | 14 hours |
| Excretion | Bile |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C33H35FN2O5 |
| Molar mass | 558.64 g·mol−1 |
| 3D model (JSmol) | |
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Atorvastatin, sold under the brand name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels.[2] For the prevention of cardiovascular disease, statins are a first-line treatment.[2] It is taken by mouth.[2]
Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains.[2] Serious side effects may include rhabdomyolysis, liver problems, and diabetes.[2] Use during pregnancy may harm the baby.[2] Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing cholesterol.[2]
Atorvastatin was patented in 1986, and approved for medical use in the United States in 1996.[2][4] It is on the World Health Organization's List of Essential Medicines as an alternative to simvastatin.[5] It is available as a generic medication and is relatively inexpensive.[2][6] In 2018, it was the most prescribed medication in the United States, with more than 112 million prescriptions.[7]
References
- ^ a b c "Atorvastatin (Lipitor) Use During Pregnancy". Drugs.com. 3 February 2020. Archived from the original on 4 December 2019. Retrieved 26 February 2020.
- ^ a b c d e f g h i j k "Atorvastatin Calcium Monograph for Professionals". Drugs.com. AHFS. Archived from the original on 25 October 2010. Retrieved 23 December 2018.
- ^ Cite error: The named reference
WHO2020DDDwas invoked but never defined (see the help page). - ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 473. ISBN 9783527607495. Archived from the original on 16 May 2021. Retrieved 10 May 2020.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ^ Cite error: The named reference
Hit2014was invoked but never defined (see the help page). - ^ "The Top 300 of 2021". clincalc.com. Archived from the original on 12 February 2021. Retrieved 20 November 2020.