User:Andrew Su/Sandbox/log
< User:Andrew Su | Sandbox
Log file for Protein Box Bot
Log page index: User:ProteinBoxBot/PBB_Log_Index
| HUGO Symbol | Action Summary | Target page(s) | WP Symbol Search |
|---|---|---|---|
| AKT1 | Updated | AKT1 | |
| APOE | Updated | Apolipoprotein E | |
| APP | Updated | Amyloid precursor protein | |
| AR | Manual inspection | AR, Androgen_receptor, AIS, DHTR, HUMARA, KD, NR3C4, SBMA, SMAX1, TFM | [1] |
| BCL2 | Manual inspection | BCL2, B-cell CLL/lymphoma 2, Bcl-2 | [2] |
| BRCA1 | Manual inspection | BRCA1, Breast cancer 1, early onset, BRCAI, BRCC1, IRIS, PSCP, RNF53 | [3] |
| CASP3 | Manual inspection | CASP3, Caspase 3, CPP32, CPP32B, SCA-1 | [4] |
| CDKN1A | Manual inspection | CDKN1A, Cyclin-dependent kinase inhibitor 1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | [5] |
| CDKN2A | Manual inspection | CDKN2A, Cyclin-dependent kinase inhibitor 2A, ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, TP16, p14, p14ARF, p16, p16INK4, p16INK4a, p19 | [6] |
| CTNNB1 | Manual inspection | CTNNB1, Catenin, CTNNB, FLJ25606 | [7] |
| EGFR | Manual inspection | EGFR, Epidermal growth factor receptor, ERBB, ERBB1, mENA | [8] |
Action summary
- Created -- no namespace conflicts; created page with gene symbol
- Updated -- found one and only one page with PBB_Controls in symbol/aliases/name, or in Protein_Directory; updated with new content
- Manual inspection -- namespace conflict(s) found, but none (or rarely, multiple) have PBB_Controls; Target page(s) shows all possible links
- NOTE: When searching for PBB_Controls, follow all redirects (e.g., CTNNB1)
Target gene(s)
- If Action Summary is "Created" or "Updated"...
- Target gene is the name of created/updated gene page
- If Action Summary is "Manual inspection"...
- First link (bolded) is gene symbol
- Second link (bolded) is gene name/description. Remove all phrases between parentheses, and all text after the first comma
- All subsequent links are gene aliases
Vebose Log - Date: 17:34, 11 September 2007 (UTC)
AKT1
- REDIRECT: Protein Redirected to: AKT1 {September 11, 2007 10:21:38 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {September 11, 2007 10:21:40 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {September 11, 2007 10:21:40 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {September 11, 2007 10:21:40 AM PDT}
- UPDATED: Updated protein page: AKT1 {September 11, 2007 10:21:47 AM PDT}
APOE
- REDIRECT: Protein Redirected to: Apolipoprotein E {September 11, 2007 10:22:03 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {September 11, 2007 10:22:05 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {September 11, 2007 10:22:05 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {September 11, 2007 10:22:05 AM PDT}
- UPDATED: Updated protein page: Apolipoprotein E {September 11, 2007 10:22:13 AM PDT}
APP
- REDIRECT: Protein Redirected to: Amyloid_precursor_protein {September 11, 2007 10:22:34 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {September 11, 2007 10:22:35 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {September 11, 2007 10:22:35 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {September 11, 2007 10:22:35 AM PDT}
- UPDATED: Updated protein page: Amyloid_precursor_protein {September 11, 2007 10:22:44 AM PDT}
AR
- REDIRECT: Protein Redirected to: Androgen_receptor {September 11, 2007 10:23:16 AM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: Androgen_receptor. Invoking a Mandantory Inspection. {September 11, 2007 10:23:20 AM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
'''Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)''', also known as '''AR''', is a human [[gene]].
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_AR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e3g.
| PDB = {{PDB2|1e3g}}, {{PDB2|1gs4}}, {{PDB2|1i37}}, {{PDB2|1i38}}, {{PDB2|1r4i}}, {{PDB2|1t5z}}, {{PDB2|1t63}}, {{PDB2|1t65}}, {{PDB2|1t73}}, {{PDB2|1t74}}, {{PDB2|1t76}}, {{PDB2|1t79}}, {{PDB2|1t7f}}, {{PDB2|1t7m}}, {{PDB2|1t7r}}, {{PDB2|1t7t}}, {{PDB2|1xj7}}, {{PDB2|1xnn}}, {{PDB2|1xow}}, {{PDB2|1xq3}}, {{PDB2|1z95}}, {{PDB2|2am9}}, {{PDB2|2ama}}, {{PDB2|2amb}}, {{PDB2|2ao6}}, {{PDB2|2ax6}}, {{PDB2|2ax7}}, {{PDB2|2ax8}}, {{PDB2|2ax9}}, {{PDB2|2axa}}, {{PDB2|2ihq}}, {{PDB2|2nw4}}, {{PDB2|2oz7}}
| Name = Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)
| HGNCid = 644
| Symbol = AR
| AltSymbols =; AIS; DHTR; HUMARA; KD; NR3C4; SBMA; SMAX1; TFM
| OMIM = 313700
| ECnumber =
| Homologene = 28
| MGIid = 88064
| GeneAtlas_image1 = PBB_GE_AR_211110_s_at.png
| GeneAtlas_image2 = PBB_GE_AR_211621_at.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004882 |text = androgen receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0005497 |text = androgen binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007548 |text = sex differentiation}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008584 |text = male gonad development}} {{GNF_GO|id=GO:0016049 |text = cell growth}} {{GNF_GO|id=GO:0019102 |text = male somatic sex determination}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0030850 |text = prostate gland development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 367
| Hs_Ensembl = ENSG00000169083
| Hs_RefseqProtein = NP_000035
| Hs_RefseqmRNA = NM_000044
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 66681190
| Hs_GenLoc_end = 66867186
| Hs_Uniprot = P10275
| Mm_EntrezGene = 11835
| Mm_Ensembl = ENSMUSG00000046532
| Mm_RefseqmRNA = NM_013476
| Mm_RefseqProtein = NP_038504
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 94352469
| Mm_GenLoc_end = 94519866
| Mm_Uniprot = P19091
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.<ref>{{cite web | title = Entrez Gene: AR androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=367| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pinsky L, Trifiro M, Kaufman M, ''et al.'' |title=Androgen resistance due to mutation of the androgen receptor. |journal=Clinical and investigative medicine. Médecine clinique et experimentale |volume=15 |issue= 5 |pages= 456-72 |year= 1993 |pmid= 1458719 |doi= }}
*{{cite journal | author=Veldscholte J, Berrevoets CA, Ris-Stalpers C, ''et al.'' |title=The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens. |journal=J. Steroid Biochem. Mol. Biol. |volume=41 |issue= 3-8 |pages= 665-9 |year= 1992 |pmid= 1562539 |doi= }}
*{{cite journal | author=Brinkmann AO, Jenster G, Ris-Stalpers C, ''et al.'' |title=Androgen receptor mutations. |journal=J. Steroid Biochem. Mol. Biol. |volume=53 |issue= 1-6 |pages= 443-8 |year= 1995 |pmid= 7626493 |doi= }}
*{{cite journal | author=Quigley CA, De Bellis A, Marschke KB, ''et al.'' |title=Androgen receptor defects: historical, clinical, and molecular perspectives. |journal=Endocr. Rev. |volume=16 |issue= 3 |pages= 271-321 |year= 1995 |pmid= 7671849 |doi= }}
*{{cite journal | author=Sultan C, Lumbroso S, Poujol N, ''et al.'' |title=Mutations of androgen receptor gene in androgen insensitivity syndromes. |journal=J. Steroid Biochem. Mol. Biol. |volume=46 |issue= 5 |pages= 519-30 |year= 1994 |pmid= 8240973 |doi= }}
*{{cite journal | author=Yong EL, Tut TG, Ghadessy FJ, ''et al.'' |title=Partial androgen insensitivity and correlations with the predicted three dimensional structure of the androgen receptor ligand-binding domain. |journal=Mol. Cell. Endocrinol. |volume=137 |issue= 1 |pages= 41-50 |year= 1999 |pmid= 9607727 |doi= }}
*{{cite journal | author=Jänne OA, Moilanen AM, Poukka H, ''et al.'' |title=Androgen-receptor-interacting nuclear proteins. |journal=Biochem. Soc. Trans. |volume=28 |issue= 4 |pages= 401-5 |year= 2001 |pmid= 10961928 |doi= }}
*{{cite journal | author=Yeh S, Sampson ER, Lee DK, ''et al.'' |title=Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer. |journal=J. Formos. Med. Assoc. |volume=99 |issue= 12 |pages= 885-94 |year= 2001 |pmid= 11155740 |doi= }}
*{{cite journal | author=Loy CJ, Yong EL |title=Sex, infertility and the molecular biology of the androgen receptor. |journal=Curr. Opin. Obstet. Gynecol. |volume=13 |issue= 3 |pages= 315-21 |year= 2001 |pmid= 11396657 |doi= }}
*{{cite journal | author=Roy AK, Tyagi RK, Song CS, ''et al.'' |title=Androgen receptor: structural domains and functional dynamics after ligand-receptor interaction. |journal=Ann. N. Y. Acad. Sci. |volume=949 |issue= |pages= 44-57 |year= 2002 |pmid= 11795379 |doi= }}
*{{cite journal | author=He B, Wilson EM |title=The NH(2)-terminal and carboxyl-terminal interaction in the human androgen receptor. |journal=Mol. Genet. Metab. |volume=75 |issue= 4 |pages= 293-8 |year= 2002 |pmid= 12051960 |doi= 10.1016/S1096-7192(02)00009-4 }}
*{{cite journal | author=Culig Z, Klocker H, Bartsch G, Hobisch A |title=Androgen receptor mutations in carcinoma of the prostate: significance for endocrine therapy. |journal=American journal of pharmacogenomics : genomics-related research in drug development and clinical practice |volume=1 |issue= 4 |pages= 241-9 |year= 2002 |pmid= 12083956 |doi= }}
*{{cite journal | author=Ferro P, Catalano MG, Dell'Eva R, ''et al.'' |title=The androgen receptor CAG repeat: a modifier of carcinogenesis? |journal=Mol. Cell. Endocrinol. |volume=193 |issue= 1-2 |pages= 109-20 |year= 2003 |pmid= 12161010 |doi= }}
*{{cite journal | author=Sultan Ch, Gobinet J, Terouanne B, ''et al.'' |title=[The androgen receptor: molecular pathology] |journal=J. Soc. Biol. |volume=196 |issue= 3 |pages= 223-40 |year= 2003 |pmid= 12465595 |doi= }}
*{{cite journal | author=Walcott JL, Merry DE |title=Trinucleotide repeat disease. The androgen receptor in spinal and bulbar muscular atrophy. |journal=Vitam. Horm. |volume=65 |issue= |pages= 127-47 |year= 2003 |pmid= 12481545 |doi= }}
*{{cite journal | author=Bonaccorsi L, Muratori M, Carloni V, ''et al.'' |title=Androgen receptor and prostate cancer invasion. |journal=Int. J. Androl. |volume=26 |issue= 1 |pages= 21-5 |year= 2003 |pmid= 12534934 |doi= }}
*{{cite journal | author=Verrijdt G, Haelens A, Claessens F |title=Selective DNA recognition by the androgen receptor as a mechanism for hormone-specific regulation of gene expression. |journal=Mol. Genet. Metab. |volume=78 |issue= 3 |pages= 175-85 |year= 2004 |pmid= 12649062 |doi= }}
*{{cite journal | author=Santos AF, Huang H, Tindall DJ |title=The androgen receptor: a potential target for therapy of prostate cancer. |journal=Steroids |volume=69 |issue= 2 |pages= 79-85 |year= 2004 |pmid= 15013685 |doi= 10.1016/j.steroids.2003.10.005 }}
*{{cite journal | author=Mazen I, Lumbroso S, Abdel Ghaffar S, ''et al.'' |title=Mutation of the androgen receptor (R840S) in an Egyptian patient with partial androgen insensitivity syndrome: review of the literature on the clinical expression of different R840 substitutions. |journal=J. Endocrinol. Invest. |volume=27 |issue= 1 |pages= 57-60 |year= 2004 |pmid= 15053245 |doi= }}
*{{cite journal | author=Black BE, Paschal BM |title=Intranuclear organization and function of the androgen receptor. |journal=Trends Endocrinol. Metab. |volume=15 |issue= 9 |pages= 411-7 |year= 2005 |pmid= 15519887 |doi= 10.1016/j.tem.2004.09.006 }}
*{{cite journal | author=Tufan AC, Satiroglu-Tufan NL, Aydinuraz B, ''et al.'' |title=No association of the CAG repeat length in exon 1 of the androgen receptor gene with idiopathic infertility in Turkish men: implications and literature review. |journal=Tohoku J. Exp. Med. |volume=206 |issue= 2 |pages= 105-15 |year= 2005 |pmid= 15888966 |doi= }}
*{{cite journal | author=Morel Y, Michel-Calemard L, Mallet D |title=[Genetic anomalies of the androgen receptor and sexual ambiguity with normal testicular function at birth] |journal=Ann. Endocrinol. (Paris) |volume=66 |issue= 3 |pages= 217-24 |year= 2005 |pmid= 15988382 |doi= }}
*{{cite journal | author=Rajender S, Singh L, Thangaraj K |title=Phenotypic heterogeneity of mutations in androgen receptor gene. |journal=Asian J. Androl. |volume=9 |issue= 2 |pages= 147-79 |year= 2007 |pmid= 17334586 |doi= 10.1111/j.1745-7262.2007.00250.x }}
*{{cite journal | author=Comstock CE, Knudsen KE |title=The complex role of AR signaling after cytotoxic insult: implications for cell-cycle-based chemotherapeutics. |journal=Cell Cycle |volume=6 |issue= 11 |pages= 1307-13 |year= 2007 |pmid= 17568191 |doi= }}
}}
{{refend}}
BCL2
- REDIRECT: Protein Redirected to: Bcl-2 {September 11, 2007 10:23:39 AM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: Bcl-2. Invoking a Mandantory Inspection. {September 11, 2007 10:23:43 AM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
'''B-cell CLL/lymphoma 2''', also known as '''BCL2''', is a human [[gene]].
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BCL2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2o2f.
| PDB = {{PDB2|2o2f}}
| Name = B-cell CLL/lymphoma 2
| HGNCid = 990
| Symbol = BCL2
| AltSymbols =; Bcl-2
| OMIM = 151430
| ECnumber =
| Homologene = 527
| MGIid = 88138
| GeneAtlas_image1 = PBB_GE_BCL2_203685_at.png
| GeneAtlas_image2 = PBB_GE_BCL2_203684_s_at.png
| GeneAtlas_image3 = PBB_GE_BCL2_207005_s_at.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005741 |text = mitochondrial outer membrane}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0001836 |text = release of cytochrome c from mitochondria}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006959 |text = humoral immune response}} {{GNF_GO|id=GO:0051453 |text = regulation of cellular pH}} {{GNF_GO|id=GO:0051902 |text = negative regulation of mitochondrial depolarization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 596
| Hs_Ensembl = ENSG00000171791
| Hs_RefseqProtein = NP_000624
| Hs_RefseqmRNA = NM_000633
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 58941559
| Hs_GenLoc_end = 59137593
| Hs_Uniprot = P10415
| Mm_EntrezGene = 12043
| Mm_Ensembl = ENSMUSG00000057329
| Mm_RefseqmRNA = NM_009741
| Mm_RefseqProtein = NP_033871
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 108365740
| Mm_GenLoc_end = 108541821
| Mm_Uniprot = Q4VBF6
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.<ref>{{cite web | title = Entrez Gene: BCL2 B-cell CLL/lymphoma 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=596| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Reed JC, Zha H, Aime-Sempe C, ''et al.'' |title=Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death. |journal=Adv. Exp. Med. Biol. |volume=406 |issue= |pages= 99-112 |year= 1997 |pmid= 8910675 |doi= }}
*{{cite journal | author=Zauli G, Gibellini D |title=The human immunodeficiency virus type-1 (HIV-1) Tat protein and Bcl-2 gene expression. |journal=Leuk. Lymphoma |volume=23 |issue= 5-6 |pages= 551-60 |year= 1997 |pmid= 9031086 |doi= }}
*{{cite journal | author=Deng X, Kornblau SM, Ruvolo PP, May WS |title=Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance. |journal=J. Natl. Cancer Inst. Monographs |volume= |issue= 28 |pages= 30-7 |year= 2003 |pmid= 11158204 |doi= }}
*{{cite journal | author=Vieira HL, Haouzi D, El Hamel C, ''et al.'' |title=Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator. |journal=Cell Death Differ. |volume=7 |issue= 12 |pages= 1146-54 |year= 2001 |pmid= 11175251 |doi= 10.1038/sj.cdd.4400778 }}
*{{cite journal | author=Ruvolo PP, Deng X, May WS |title=Phosphorylation of Bcl2 and regulation of apoptosis. |journal=Leukemia |volume=15 |issue= 4 |pages= 515-22 |year= 2001 |pmid= 11368354 |doi= }}
*{{cite journal | author=Marone M, Bonanno G, Rutella S, ''et al.'' |title=Survival and cell cycle control in early hematopoiesis: role of bcl-2, and the cyclin dependent kinase inhibitors P27 and P21. |journal=Leuk. Lymphoma |volume=43 |issue= 1 |pages= 51-7 |year= 2003 |pmid= 11908736 |doi= }}
*{{cite journal | author=Irvine AE, McMullin MF, Ong YL |title=Bcl-2 family members as prognostic indicators in AML. |journal=Hematology |volume=7 |issue= 1 |pages= 21-31 |year= 2002 |pmid= 12171774 |doi= 10.1080/10245330290011838 }}
*{{cite journal | author=Cory S, Adams JM |title=The Bcl2 family: regulators of the cellular life-or-death switch. |journal=Nat. Rev. Cancer |volume=2 |issue= 9 |pages= 647-56 |year= 2002 |pmid= 12209154 |doi= 10.1038/nrc883 }}
*{{cite journal | author=Catz SD, Johnson JL |title=BCL-2 in prostate cancer: a minireview. |journal=Apoptosis |volume=8 |issue= 1 |pages= 29-37 |year= 2003 |pmid= 12510149 |doi= }}
*{{cite journal | author=Ouyang YB, Giffard RG |title=Cellular neuroprotective mechanisms in cerebral ischemia: Bcl-2 family proteins and protection of mitochondrial function. |journal=Cell Calcium |volume=36 |issue= 3-4 |pages= 303-11 |year= 2005 |pmid= 15261486 |doi= 10.1016/j.ceca.2004.02.015 }}
*{{cite journal | author=Seelamgari A, Maddukuri A, Berro R, ''et al.'' |title=Role of viral regulatory and accessory proteins in HIV-1 replication. |journal=Front. Biosci. |volume=9 |issue= |pages= 2388-413 |year= 2006 |pmid= 15353294 |doi= }}
*{{cite journal | author=Hadar T, Shvero J, Yaniv E, ''et al.'' |title=Expression of p53, Ki-67 and Bcl-2 in parathyroid adenoma and residual normal tissue. |journal=Pathol. Oncol. Res. |volume=11 |issue= 1 |pages= 45-9 |year= 2005 |pmid= 15800682 |doi= PAOR.2005.11.1.0045 }}
*{{cite journal | author=Muthumani K, Choo AY, Premkumar A, ''et al.'' |title=Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism. |journal=Cell Death Differ. |volume=12 Suppl 1 |issue= |pages= 962-70 |year= 2006 |pmid= 15832179 |doi= 10.1038/sj.cdd.4401583 }}
*{{cite journal | author=Soane L, Fiskum G |title=Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteins. |journal=J. Bioenerg. Biomembr. |volume=37 |issue= 3 |pages= 179-90 |year= 2006 |pmid= 16167175 |doi= 10.1007/s10863-005-6590-8 }}
}}
{{refend}}
BRCA1
- REDIRECT: Protein Redirected to: BRCA1 {September 11, 2007 10:24:08 AM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: BRCA1. Invoking a Mandantory Inspection. {September 11, 2007 10:24:11 AM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
'''Breast cancer 1, early onset''', also known as '''BRCA1''', is a human [[gene]].
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_BRCA1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jm7.
| PDB = {{PDB2|1jm7}}, {{PDB2|1jnx}}, {{PDB2|1n5o}}, {{PDB2|1oqa}}, {{PDB2|1t15}}, {{PDB2|1t29}}, {{PDB2|1t2u}}, {{PDB2|1t2v}}, {{PDB2|1y98}}
| Name = Breast cancer 1, early onset
| HGNCid = 1100
| Symbol = BRCA1
| AltSymbols =; BRCAI; BRCC1; IRIS; PSCP; RNF53
| OMIM = 113705
| ECnumber =
| Homologene = 5276
| MGIid = 104537
| GeneAtlas_image1 = PBB_GE_BRCA1_204531_s_at.png
| GeneAtlas_image2 = PBB_GE_BRCA1_211851_x_at.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0015631 |text = tubulin binding}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0000151 |text = ubiquitin ligase complex}} {{GNF_GO|id=GO:0000793 |text = condensed chromosome}} {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0008274 |text = gamma-tubulin ring complex}} {{GNF_GO|id=GO:0031436 |text = BRCA1-BARD1 complex}}
| Process = {{GNF_GO|id=GO:0000075 |text = cell cycle checkpoint}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006359 |text = regulation of transcription from RNA polymerase III promoter}} {{GNF_GO|id=GO:0006633 |text = fatty acid biosynthetic process}} {{GNF_GO|id=GO:0006978 |text = DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}} {{GNF_GO|id=GO:0007098 |text = centrosome cycle}} {{GNF_GO|id=GO:0008630 |text = DNA damage response, signal transduction resulting in induction of apoptosis}} {{GNF_GO|id=GO:0009048 |text = dosage compensation, by inactivation of X chromosome}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0031398 |text = positive regulation of protein ubiquitination}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0045717 |text = negative regulation of fatty acid biosynthetic process}} {{GNF_GO|id=GO:0045739 |text = positive regulation of DNA repair}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0046600 |text = negative regulation of centriole replication}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 672
| Hs_Ensembl = ENSG00000012048
| Hs_RefseqProtein = NP_009225
| Hs_RefseqmRNA = NM_007294
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 38449840
| Hs_GenLoc_end = 38530994
| Hs_Uniprot = P38398
| Mm_EntrezGene = 12189
| Mm_Ensembl = ENSMUSG00000017146
| Mm_RefseqmRNA = NM_009764
| Mm_RefseqProtein = NP_033894
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 101305657
| Mm_GenLoc_end = 101367902
| Mm_Uniprot = Q3UMS5
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified.<ref>{{cite web | title = Entrez Gene: BRCA1 breast cancer 1, early onset| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=672| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Paterson JW |title=BRCA1: a review of structure and putative functions. |journal=Dis. Markers |volume=13 |issue= 4 |pages= 261-74 |year= 1998 |pmid= 9553742 |doi= }}
*{{cite journal | author=Yang X, Lippman ME |title=BRCA1 and BRCA2 in breast cancer. |journal=Breast Cancer Res. Treat. |volume=54 |issue= 1 |pages= 1-10 |year= 1999 |pmid= 10369075 |doi= }}
*{{cite journal | author=Deng CX, Brodie SG |title=Roles of BRCA1 and its interacting proteins. |journal=Bioessays |volume=22 |issue= 8 |pages= 728-37 |year= 2000 |pmid= 10918303 |doi= 10.1002/1521-1878(200008)22:8<728::AID-BIES6>3.0.CO;2-B }}
*{{cite journal | author=McGowan CH |title=Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor. |journal=Bioessays |volume=24 |issue= 6 |pages= 502-11 |year= 2002 |pmid= 12111733 |doi= 10.1002/bies.10101 }}
*{{cite journal | author=Deng CX |title=Roles of BRCA1 in centrosome duplication. |journal=Oncogene |volume=21 |issue= 40 |pages= 6222-7 |year= 2002 |pmid= 12214252 |doi= 10.1038/sj.onc.1205713 }}
*{{cite journal | author=Daniel DC |title=Highlight: BRCA1 and BRCA2 proteins in breast cancer. |journal=Microsc. Res. Tech. |volume=59 |issue= 1 |pages= 68-83 |year= 2002 |pmid= 12242698 |doi= 10.1002/jemt.10178 }}
*{{cite journal | author=Kubista M, Rosner M, Miloloza A, ''et al.'' |title=Brca1 and differentiation. |journal=Mutat. Res. |volume=512 |issue= 2-3 |pages= 165-72 |year= 2003 |pmid= 12464350 |doi= }}
*{{cite journal | author=Tutt A, Ashworth A |title=The relationship between the roles of BRCA genes in DNA repair and cancer predisposition. |journal=Trends in molecular medicine |volume=8 |issue= 12 |pages= 571-6 |year= 2003 |pmid= 12470990 |doi= }}
*{{cite journal | author=El-Deiry WS |title=Transactivation of repair genes by BRCA1. |journal=Cancer Biol. Ther. |volume=1 |issue= 5 |pages= 490-1 |year= 2003 |pmid= 12496474 |doi= }}
*{{cite journal | author=Somasundaram K |title=Breast cancer gene 1 (BRCA1): role in cell cycle regulation and DNA repair--perhaps through transcription. |journal=J. Cell. Biochem. |volume=88 |issue= 6 |pages= 1084-91 |year= 2003 |pmid= 12647291 |doi= 10.1002/jcb.10469 }}
*{{cite journal | author=Deng CX, Wang RH |title=Roles of BRCA1 in DNA damage repair: a link between development and cancer. |journal=Hum. Mol. Genet. |volume=12 Spec No 1 |issue= |pages= R113-23 |year= 2003 |pmid= 12668603 |doi= }}
*{{cite journal | author=Lou Z, Chen J |title=BRCA proteins and DNA damage checkpoints. |journal=Front. Biosci. |volume=8 |issue= |pages= s718-21 |year= 2004 |pmid= 12700125 |doi= }}
*{{cite journal | author=Rosen EM, Fan S, Pestell RG, Goldberg ID |title=BRCA1 gene in breast cancer. |journal=J. Cell. Physiol. |volume=196 |issue= 1 |pages= 19-41 |year= 2003 |pmid= 12767038 |doi= 10.1002/jcp.10257 }}
*{{cite journal | author=Mullineaux LG, Castellano TM, Shaw J, ''et al.'' |title=Identification of germline 185delAG BRCA1 mutations in non-Jewish Americans of Spanish ancestry from the San Luis Valley, Colorado. |journal=Cancer |volume=98 |issue= 3 |pages= 597-602 |year= 2003 |pmid= 12879478 |doi= 10.1002/cncr.11533 }}
*{{cite journal | author=Hartman AR, Ford JM |title=BRCA1 and p53: compensatory roles in DNA repair. |journal=J. Mol. Med. |volume=81 |issue= 11 |pages= 700-7 |year= 2004 |pmid= 13679996 |doi= 10.1007/s00109-003-0477-0 }}
*{{cite journal | author=Rosen EM, Fan S, Pestell RG, Goldberg ID |title=BRCA1 in hormone-responsive cancers. |journal=Trends Endocrinol. Metab. |volume=14 |issue= 8 |pages= 378-85 |year= 2004 |pmid= 14516936 |doi= }}
*{{cite journal | author=McCoy ML, Mueller CR, Roskelley CD |title=The role of the breast cancer susceptibility gene 1 (BRCA1) in sporadic epithelial ovarian cancer. |journal=Reprod. Biol. Endocrinol. |volume=1 |issue= |pages= 72 |year= 2004 |pmid= 14613551 |doi= 10.1186/1477-7827-1-72 }}
*{{cite journal | author=Levine DA, Argenta PA, Yee CJ, ''et al.'' |title=Fallopian tube and primary peritoneal carcinomas associated with BRCA mutations. |journal=J. Clin. Oncol. |volume=21 |issue= 22 |pages= 4222-7 |year= 2003 |pmid= 14615451 |doi= 10.1200/JCO.2003.04.131 }}
*{{cite journal | author=Feunteun J |title=[A paradox and three egnimas about the role of BRCA1 in breast and ovarian cancers] |journal=J. Soc. Biol. |volume=198 |issue= 2 |pages= 123-6 |year= 2004 |pmid= 15368961 |doi= }}
*{{cite journal | author=Sunpaweravong S, Sunpaweravong P |title=Recent developments in critical genes in the molecular biology of breast cancer. |journal=Asian journal of surgery / Asian Surgical Association |volume=28 |issue= 1 |pages= 71-5 |year= 2005 |pmid= 15691805 |doi= }}
*{{cite journal | author=Aiyar S, Sun JL, Li R |title=BRCA1: a locus-specific "liaison" in gene expression and genetic integrity. |journal=J. Cell. Biochem. |volume=94 |issue= 6 |pages= 1103-11 |year= 2005 |pmid= 15723343 |doi= 10.1002/jcb.20386 }}
*{{cite journal | author=Dumitrescu RG, Cotarla I |title=Understanding breast cancer risk -- where do we stand in 2005? |journal=J. Cell. Mol. Med. |volume=9 |issue= 1 |pages= 208-21 |year= 2005 |pmid= 15784178 |doi= }}
*{{cite journal | author=Gonçalves A, Viens P, Sobol H, ''et al.'' |title=[Molecular alterations in breast cancer: clinical implications and new analytical tools] |journal=La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne |volume=26 |issue= 6 |pages= 470-8 |year= 2005 |pmid= 15936476 |doi= 10.1016/j.revmed.2004.11.012 }}
*{{cite journal | author=Durant ST, Nickoloff JA |title=Good timing in the cell cycle for precise DNA repair by BRCA1. |journal=Cell Cycle |volume=4 |issue= 9 |pages= 1216-22 |year= 2006 |pmid= 16103751 |doi= }}
*{{cite journal | author=Rosen EM, Fan S, Isaacs C |title=BRCA1 in hormonal carcinogenesis: basic and clinical research. |journal=Endocr. Relat. Cancer |volume=12 |issue= 3 |pages= 533-48 |year= 2005 |pmid= 16172191 |doi= 10.1677/erc.1.00972 }}
*{{cite journal | author=Lee Y, Medeiros F, Kindelberger D, ''et al.'' |title=Advances in the recognition of tubal intraepithelial carcinoma: applications to cancer screening and the pathogenesis of ovarian cancer. |journal=Advances in anatomic pathology |volume=13 |issue= 1 |pages= 1-7 |year= 2006 |pmid= 16462151 |doi= 10.1097/01.pap.0000201826.46978.e5 }}
*{{cite journal | author=Starita LM, Parvin JD |title=Substrates of the BRCA1-dependent ubiquitin ligase. |journal=Cancer Biol. Ther. |volume=5 |issue= 2 |pages= 137-41 |year= 2006 |pmid= 16479151 |doi= }}
*{{cite journal | author=Domchek SM, Weber BL |title=Clinical management of BRCA1 and BRCA2 mutation carriers. |journal=Oncogene |volume=25 |issue= 43 |pages= 5825-31 |year= 2006 |pmid= 16998496 |doi= 10.1038/sj.onc.1209881 }}
*{{cite journal | author=Honrado E, Osorio A, Palacios J, Benitez J |title=Pathology and gene expression of hereditary breast tumors associated with BRCA1, BRCA2 and CHEK2 gene mutations. |journal=Oncogene |volume=25 |issue= 43 |pages= 5837-45 |year= 2006 |pmid= 16998498 |doi= 10.1038/sj.onc.1209875 }}
*{{cite journal | author=Turner NC, Reis-Filho JS |title=Basal-like breast cancer and the BRCA1 phenotype. |journal=Oncogene |volume=25 |issue= 43 |pages= 5846-53 |year= 2006 |pmid= 16998499 |doi= 10.1038/sj.onc.1209876 }}
*{{cite journal | author=Mullan PB, Quinn JE, Harkin DP |title=The role of BRCA1 in transcriptional regulation and cell cycle control. |journal=Oncogene |volume=25 |issue= 43 |pages= 5854-63 |year= 2006 |pmid= 16998500 |doi= 10.1038/sj.onc.1209872 }}
}}
{{refend}}
CASP3
- REDIRECT: Protein Redirected to: Caspase 3 {September 11, 2007 10:24:19 AM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: Caspase 3. Invoking a Mandantory Inspection. {September 11, 2007 10:24:22 AM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
'''Caspase 3, apoptosis-related cysteine peptidase''', also known as '''CASP3''', is a human [[gene]].
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CASP3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cp3.
| PDB = {{PDB2|1cp3}}, {{PDB2|1gfw}}, {{PDB2|1i3o}}, {{PDB2|1nme}}, {{PDB2|1nmq}}, {{PDB2|1nms}}, {{PDB2|1pau}}, {{PDB2|1qx3}}, {{PDB2|1re1}}, {{PDB2|1rhj}}, {{PDB2|1rhk}}, {{PDB2|1rhm}}, {{PDB2|1rhq}}, {{PDB2|1rhr}}, {{PDB2|1rhu}}, {{PDB2|2c1e}}, {{PDB2|2c2k}}, {{PDB2|2c2m}}, {{PDB2|2c2o}}, {{PDB2|2cdr}}, {{PDB2|2cjx}}, {{PDB2|2cjy}}, {{PDB2|2cnk}}, {{PDB2|2cnl}}, {{PDB2|2cnn}}, {{PDB2|2cno}}, {{PDB2|2dko}}, {{PDB2|2h5i}}, {{PDB2|2h5j}}, {{PDB2|2h65}}, {{PDB2|2j30}}, {{PDB2|2j31}}, {{PDB2|2j32}}, {{PDB2|2j33}}
| Name = Caspase 3, apoptosis-related cysteine peptidase
| HGNCid = 1504
| Symbol = CASP3
| AltSymbols =; CPP32; CPP32B; SCA-1
| OMIM = 600636
| ECnumber =
| Homologene = 37912
| MGIid = 107739
| GeneAtlas_image1 = PBB_GE_CASP3_202763_at.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0004861 |text = cyclin-dependent protein kinase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008234 |text = cysteine-type peptidase activity}} {{GNF_GO|id=GO:0030693 |text = caspase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001782 |text = B cell homeostasis}} {{GNF_GO|id=GO:0001836 |text = release of cytochrome c from mitochondria}} {{GNF_GO|id=GO:0006309 |text = DNA fragmentation during apoptosis}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008625 |text = induction of apoptosis via death domain receptors}} {{GNF_GO|id=GO:0008631 |text = induction of apoptosis by oxidative stress}} {{GNF_GO|id=GO:0009411 |text = response to UV}} {{GNF_GO|id=GO:0009611 |text = response to wounding}} {{GNF_GO|id=GO:0030216 |text = keratinocyte differentiation}} {{GNF_GO|id=GO:0030889 |text = negative regulation of B cell proliferation}} {{GNF_GO|id=GO:0043029 |text = T cell homeostasis}} {{GNF_GO|id=GO:0045165 |text = cell fate commitment}} {{GNF_GO|id=GO:0045736 |text = negative regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0046007 |text = negative regulation of activated T cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 836
| Hs_Ensembl = ENSG00000164305
| Hs_RefseqProtein = NP_004337
| Hs_RefseqmRNA = NM_004346
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 185785845
| Hs_GenLoc_end = 185807623
| Hs_Uniprot = P42574
| Mm_EntrezGene = 12367
| Mm_Ensembl = ENSMUSG00000031628
| Mm_RefseqmRNA = XM_991820
| Mm_RefseqProtein = XP_996914
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 48116235
| Mm_GenLoc_end = 48137523
| Mm_Uniprot = Q8BNT4
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.<ref>{{cite web | title = Entrez Gene: CASP3 caspase 3, apoptosis-related cysteine peptidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=836| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Cohen GM |title=Caspases: the executioners of apoptosis. |journal=Biochem. J. |volume=326 ( Pt 1) |issue= |pages= 1-16 |year= 1997 |pmid= 9337844 |doi= }}
*{{cite journal | author=Roig J, Traugh JA |title=Cytostatic p21 G protein-activated protein kinase gamma-PAK. |journal=Vitam. Horm. |volume=62 |issue= |pages= 167-98 |year= 2001 |pmid= 11345898 |doi= }}
*{{cite journal | author=Zhao LJ, Zhu H |title=Structure and function of HIV-1 auxiliary regulatory protein Vpr: novel clues to drug design. |journal=Curr. Drug Targets Immune Endocr. Metabol. Disord. |volume=4 |issue= 4 |pages= 265-75 |year= 2005 |pmid= 15578977 |doi= }}
*{{cite journal | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue= |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 }}
*{{cite journal | author=Sykes MC, Mowbray AL, Jo H |title=Reversible glutathiolation of caspase-3 by glutaredoxin as a novel redox signaling mechanism in tumor necrosis factor-alpha-induced cell death. |journal=Circ. Res. |volume=100 |issue= 2 |pages= 152-4 |year= 2007 |pmid= 17272816 |doi= 10.1161/01.RES.0000258171.08020.72 }}
}}
{{refend}}
CDKN1A
- REDIRECT: Protein Redirected to: p21 {September 11, 2007 10:24:31 AM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: p21. Invoking a Mandantory Inspection. {September 11, 2007 10:24:34 AM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
'''Cyclin-dependent kinase inhibitor 1A (p21, Cip1)''', also known as '''CDKN1A''', is a human [[gene]].
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cyclin-dependent kinase inhibitor 1A (p21, Cip1)
| HGNCid = 1784
| Symbol = CDKN1A
| AltSymbols =; CAP20; CDKN1; CIP1; MDA-6; P21; SDI1; WAF1; p21CIP1
| OMIM = 116899
| ECnumber =
| Homologene = 333
| MGIid = 104556
| GeneAtlas_image1 = PBB_GE_CDKN1A_202284_s_at.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004861 |text = cyclin-dependent protein kinase inhibitor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0030332 |text = cyclin binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0000307 |text = cyclin-dependent protein kinase holoenzyme complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006974 |text = response to DNA damage stimulus}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0008629 |text = induction of apoptosis by intracellular signals}} {{GNF_GO|id=GO:0009411 |text = response to UV}} {{GNF_GO|id=GO:0030890 |text = positive regulation of B cell proliferation}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptosis}} {{GNF_GO|id=GO:0043071 |text = positive regulation of non-apoptotic programmed cell death}} {{GNF_GO|id=GO:0045736 |text = negative regulation of cyclin-dependent protein kinase activity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1026
| Hs_Ensembl = ENSG00000124762
| Hs_RefseqProtein = NP_000380
| Hs_RefseqmRNA = NM_000389
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 36754413
| Hs_GenLoc_end = 36763094
| Hs_Uniprot = P38936
| Mm_EntrezGene = 12575
| Mm_Ensembl = ENSMUSG00000023067
| Mm_RefseqmRNA = NM_007669
| Mm_RefseqProtein = NP_031695
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 28821439
| Mm_GenLoc_end = 28828386
| Mm_Uniprot = Q4FK34
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.<ref>{{cite web | title = Entrez Gene: CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1026| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Marone M, Bonanno G, Rutella S, ''et al.'' |title=Survival and cell cycle control in early hematopoiesis: role of bcl-2, and the cyclin dependent kinase inhibitors P27 and P21. |journal=Leuk. Lymphoma |volume=43 |issue= 1 |pages= 51-7 |year= 2003 |pmid= 11908736 |doi= }}
*{{cite journal | author=Fang JY, Lu YY |title=Effects of histone acetylation and DNA methylation on p21( WAF1) regulation. |journal=World J. Gastroenterol. |volume=8 |issue= 3 |pages= 400-5 |year= 2002 |pmid= 12046058 |doi= }}
*{{cite journal | author=Tokumoto M, Tsuruya K, Fukuda K, ''et al.'' |title=Parathyroid cell growth in patients with advanced secondary hyperparathyroidism: vitamin D receptor and cyclin-dependent kinase inhibitors, p21 and p27. |journal=Nephrol. Dial. Transplant. |volume=18 Suppl 3 |issue= |pages= iii9-12 |year= 2003 |pmid= 12771291 |doi= }}
*{{cite journal | author=Amini S, Khalili K, Sawaya BE |title=Effect of HIV-1 Vpr on cell cycle regulators. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 249-60 |year= 2004 |pmid= 15142382 |doi= 10.1089/104454904773819833 }}
*{{cite journal | author=Zhang Z, Wang H, Li M, ''et al.'' |title=Novel MDM2 p53-independent functions identified through RNA silencing technologies. |journal=Ann. N. Y. Acad. Sci. |volume=1058 |issue= |pages= 205-14 |year= 2006 |pmid= 16394138 |doi= 10.1196/annals.1359.030 }}
}}
{{refend}}
CDKN2A
- REDIRECT: Protein Redirected to: P16INK4a {September 11, 2007 10:24:47 AM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: P16INK4a. Invoking a Mandantory Inspection. {September 11, 2007 10:24:49 AM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
'''Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)''', also known as '''CDKN2A''', is a human [[gene]].
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CDKN2A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a5e.
| PDB = {{PDB2|1a5e}}, {{PDB2|1bi7}}, {{PDB2|1dc2}}, {{PDB2|2a5e}}
| Name = Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
| HGNCid = 1787
| Symbol = CDKN2A
| AltSymbols =; ARF; CDK4I; CDKN2; CMM2; INK4; INK4a; MLM; MTS1; TP16; p14; p14ARF; p16; p16INK4; p16INK4a; p19
| OMIM = 600160
| ECnumber =
| Homologene = 55430
| MGIid =
| GeneAtlas_image1 = PBB_GE_CDKN2A_207039_at.png
| GeneAtlas_image2 = PBB_GE_CDKN2A_209644_x_at.png
| GeneAtlas_image3 = PBB_GE_CDKN2A_211156_at.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004861 |text = cyclin-dependent protein kinase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005730 |text = nucleolus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000075 |text = cell cycle checkpoint}} {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006364 |text = rRNA processing}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0007569 |text = cell aging}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0045736 |text = negative regulation of cyclin-dependent protein kinase activity}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1029
| Hs_Ensembl = ENSG00000147889
| Hs_RefseqProtein = NP_000068
| Hs_RefseqmRNA = NM_000077
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 21957751
| Hs_GenLoc_end = 21984490
| Hs_Uniprot = P42771
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.<ref>{{cite web | title = Entrez Gene: CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1029| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Smith-Sørensen B, Hovig E |title=CDKN2A (p16INK4A) somatic and germline mutations. |journal=Hum. Mutat. |volume=7 |issue= 4 |pages= 294-303 |year= 1996 |pmid= 8723678 |doi= 10.1002/(SICI)1098-1004(1996)7:4<294::AID-HUMU2>3.0.CO;2-9 }}
*{{cite journal | author=Dracopoli NC, Fountain JW |title=CDKN2 mutations in melanoma. |journal=Cancer Surv. |volume=26 |issue= |pages= 115-32 |year= 1996 |pmid= 8783570 |doi= }}
*{{cite journal | author=Akita H |title=[Prognostic importance of altered expression of cell cycle regulators in lung cancer] |journal=Nippon Rinsho |volume=60 Suppl 5 |issue= |pages= 267-71 |year= 2003 |pmid= 12101670 |doi= }}
*{{cite journal | author=Kusy S, Larsen CJ, Roche J |title=p14ARF, p15INK4b and p16INK4a methylation status in chronic myelogenous leukemia. |journal=Leuk. Lymphoma |volume=45 |issue= 10 |pages= 1989-94 |year= 2005 |pmid= 15370242 |doi= 10.1080/10428190410001714025 }}
*{{cite journal | author=Gjerset RA |title=DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer. |journal=J. Mol. Histol. |volume=37 |issue= 5-7 |pages= 239-51 |year= 2007 |pmid= 16855788 |doi= 10.1007/s10735-006-9040-y }}
*{{cite journal | author=Yildiz IZ, Usubütün A, Firat P, ''et al.'' |title=Efficiency of immunohistochemical p16 expression and HPV typing in cervical squamous intraepithelial lesion grading and review of the p16 literature. |journal=Pathol. Res. Pract. |volume=203 |issue= 6 |pages= 445-9 |year= 2007 |pmid= 17543474 |doi= 10.1016/j.prp.2007.03.010 }}
}}
{{refend}}
CTNNB1
- REDIRECT: Protein Redirected to: Beta-catenin {September 11, 2007 10:25:05 AM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: Beta-catenin. Invoking a Mandantory Inspection. {September 11, 2007 10:25:08 AM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
'''Catenin (cadherin-associated protein), beta 1, 88kDa''', also known as '''CTNNB1''', is a human [[gene]].
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CTNNB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dow.
| PDB = {{PDB2|1dow}}, {{PDB2|1g3j}}, {{PDB2|1i7w}}, {{PDB2|1i7x}}, {{PDB2|1jdh}}, {{PDB2|1jpp}}, {{PDB2|1jpw}}, {{PDB2|1luj}}, {{PDB2|1m1e}}, {{PDB2|1qz7}}, {{PDB2|1t08}}, {{PDB2|1th1}}, {{PDB2|1v18}}, {{PDB2|2bct}}, {{PDB2|2gl7}}, {{PDB2|3bct}}
| Name = Catenin (cadherin-associated protein), beta 1, 88kDa
| HGNCid = 2514
| Symbol = CTNNB1
| AltSymbols =; CTNNB; FLJ25606
| OMIM = 116806
| ECnumber =
| Homologene = 1434
| MGIid = 88276
| GeneAtlas_image1 = PBB_GE_CTNNB1_201533_at.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0045294 |text = alpha-catenin binding}} {{GNF_GO|id=GO:0045296 |text = cadherin binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005913 |text = cell-cell adherens junction}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}} {{GNF_GO|id=GO:0016328 |text = lateral plasma membrane}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}} {{GNF_GO|id=GO:0031528 |text = microvillus membrane}} {{GNF_GO|id=GO:0045177 |text = apical part of cell}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0000904 |text = cellular morphogenesis during differentiation}} {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001569 |text = patterning of blood vessels}} {{GNF_GO|id=GO:0001706 |text = endoderm formation}} {{GNF_GO|id=GO:0001708 |text = cell fate specification}} {{GNF_GO|id=GO:0001709 |text = cell fate determination}} {{GNF_GO|id=GO:0001711 |text = endodermal cell fate commitment}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007398 |text = ectoderm development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0009950 |text = dorsal/ventral axis specification}} {{GNF_GO|id=GO:0009954 |text = proximal/distal pattern formation}} {{GNF_GO|id=GO:0010003 |text = gastrulation (sensu Mammalia)}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0016331 |text = morphogenesis of embryonic epithelium}} {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}} {{GNF_GO|id=GO:0030097 |text = hemopoiesis}} {{GNF_GO|id=GO:0030316 |text = osteoclast differentiation}} {{GNF_GO|id=GO:0030324 |text = lung development}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0030858 |text = positive regulation of epithelial cell differentiation}} {{GNF_GO|id=GO:0030900 |text = forebrain development}} {{GNF_GO|id=GO:0031016 |text = pancreas development}} {{GNF_GO|id=GO:0035116 |text = embryonic hindlimb morphogenesis}} {{GNF_GO|id=GO:0035117 |text = embryonic arm morphogenesis}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}} {{GNF_GO|id=GO:0042475 |text = odontogenesis (sensu Vertebrata)}} {{GNF_GO|id=GO:0042733 |text = embryonic digit morphogenesis}} {{GNF_GO|id=GO:0045453 |text = bone resorption}} {{GNF_GO|id=GO:0045596 |text = negative regulation of cell differentiation}} {{GNF_GO|id=GO:0045669 |text = positive regulation of osteoblast differentiation}} {{GNF_GO|id=GO:0045671 |text = negative regulation of osteoclast differentiation}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0048469 |text = cell maturation}} {{GNF_GO|id=GO:0048489 |text = synaptic vesicle transport}} {{GNF_GO|id=GO:0050808 |text = synapse organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1499
| Hs_Ensembl = ENSG00000168036
| Hs_RefseqProtein = XP_001133660
| Hs_RefseqmRNA = XM_001133660
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 41216004
| Hs_GenLoc_end = 41256938
| Hs_Uniprot = P35222
| Mm_EntrezGene = 12387
| Mm_Ensembl = ENSMUSG00000006932
| Mm_RefseqmRNA = NM_007614
| Mm_RefseqProtein = NP_031640
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 120782173
| Mm_GenLoc_end = 120809205
| Mm_Uniprot = Q3UZT7
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1499| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kikuchi A |title=Regulation of beta-catenin signaling in the Wnt pathway. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 2 |pages= 243-8 |year= 2000 |pmid= 10679188 |doi= 10.1006/bbrc.1999.1860 }}
*{{cite journal | author=Wilson PD |title=Polycystin: new aspects of structure, function, and regulation. |journal=J. Am. Soc. Nephrol. |volume=12 |issue= 4 |pages= 834-45 |year= 2001 |pmid= 11274246 |doi= }}
*{{cite journal | author=Kalluri R, Neilson EG |title=Epithelial-mesenchymal transition and its implications for fibrosis. |journal=J. Clin. Invest. |volume=112 |issue= 12 |pages= 1776-84 |year= 2004 |pmid= 14679171 |doi= 10.1172/JCI200320530 }}
*{{cite journal | author=De Ferrari GV, Moon RT |title=The ups and downs of Wnt signaling in prevalent neurological disorders. |journal=Oncogene |volume=25 |issue= 57 |pages= 7545-53 |year= 2007 |pmid= 17143299 |doi= 10.1038/sj.onc.1210064 }}
}}
{{refend}}
EGFR
- REDIRECT: Protein Redirected to: Epidermal growth factor receptor {September 11, 2007 10:25:35 AM PDT}
- BAD FORMAT: There is a problem with the BOT commands for this protein: Epidermal growth factor receptor. Invoking a Mandantory Inspection. {September 11, 2007 10:25:37 AM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
'''Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)''', also known as '''EGFR''', is a human [[gene]].
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_EGFR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ivo.
| PDB = {{PDB2|1ivo}}, {{PDB2|1m14}}, {{PDB2|1m17}}, {{PDB2|1mox}}, {{PDB2|1nql}}, {{PDB2|1xkk}}, {{PDB2|1yy9}}, {{PDB2|1z9i}}, {{PDB2|2gs2}}, {{PDB2|2gs6}}, {{PDB2|2gs7}}, {{PDB2|2itn}}, {{PDB2|2ito}}, {{PDB2|2itp}}, {{PDB2|2itq}}, {{PDB2|2itt}}, {{PDB2|2itu}}, {{PDB2|2itv}}, {{PDB2|2itw}}, {{PDB2|2itx}}, {{PDB2|2ity}}, {{PDB2|2itz}}, {{PDB2|2j5e}}, {{PDB2|2j5f}}, {{PDB2|2j6m}}
| Name = Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
| HGNCid = 3236
| Symbol = EGFR
| AltSymbols =; ERBB; ERBB1; mENA
| OMIM = 131550
| ECnumber =
| Homologene = 74545
| MGIid = 95294
| GeneAtlas_image1 = PBB_GE_EGFR_201983_s_at.png
| GeneAtlas_image2 = PBB_GE_EGFR_201984_s_at.png
| GeneAtlas_image3 = PBB_GE_EGFR_210984_x_at.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0004710 |text = MAP/ERK kinase kinase activity}} {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005006 |text = epidermal growth factor receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030235 |text = nitric-oxide synthase regulator activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}} {{GNF_GO|id=GO:0051015 |text = actin filament binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}} {{GNF_GO|id=GO:0030122 |text = AP-2 adaptor complex}} {{GNF_GO|id=GO:0030139 |text = endocytic vesicle}}
| Process = {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007202 |text = phospholipase C activation}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}} {{GNF_GO|id=GO:0030335 |text = positive regulation of cell migration}} {{GNF_GO|id=GO:0042327 |text = positive regulation of phosphorylation}} {{GNF_GO|id=GO:0043006 |text = calcium-dependent phospholipase A2 activation}} {{GNF_GO|id=GO:0043406 |text = positive regulation of MAPK activity}} {{GNF_GO|id=GO:0045429 |text = positive regulation of nitric oxide biosynthetic process}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0046777 |text = protein amino acid autophosphorylation}} {{GNF_GO|id=GO:0050679 |text = positive regulation of epithelial cell proliferation}} {{GNF_GO|id=GO:0050730 |text = regulation of peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0050999 |text = regulation of nitric-oxide synthase activity}} {{GNF_GO|id=GO:0051205 |text = protein insertion into membrane}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1956
| Hs_Ensembl = ENSG00000146648
| Hs_RefseqProtein = NP_005219
| Hs_RefseqmRNA = NM_005228
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 55054219
| Hs_GenLoc_end = 55242524
| Hs_Uniprot = P00533
| Mm_EntrezGene = 13649
| Mm_Ensembl = ENSMUSG00000020122
| Mm_RefseqmRNA = NM_007912
| Mm_RefseqProtein = NP_031938
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 16652206
| Mm_GenLoc_end = 16813912
| Mm_Uniprot = Q3TQS6
}}
}}
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Carpenter G |title=Receptors for epidermal growth factor and other polypeptide mitogens. |journal=Annu. Rev. Biochem. |volume=56 |issue= |pages= 881-914 |year= 1987 |pmid= 3039909 |doi= 10.1146/annurev.bi.56.070187.004313 }}
*{{cite journal | author=Boonstra J, Rijken P, Humbel B, ''et al.'' |title=The epidermal growth factor. |journal=Cell Biol. Int. |volume=19 |issue= 5 |pages= 413-30 |year= 1995 |pmid= 7640657 |doi= }}
*{{cite journal | author=Carpenter G |title=The EGF receptor: a nexus for trafficking and signaling. |journal=Bioessays |volume=22 |issue= 8 |pages= 697-707 |year= 2000 |pmid= 10918300 |doi= 10.1002/1521-1878(200008)22:8<697::AID-BIES3>3.0.CO;2-1 }}
*{{cite journal | author=Filardo EJ |title=Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer. |journal=J. Steroid Biochem. Mol. Biol. |volume=80 |issue= 2 |pages= 231-8 |year= 2002 |pmid= 11897506 |doi= }}
*{{cite journal | author=Tiganis T |title=Protein tyrosine phosphatases: dephosphorylating the epidermal growth factor receptor. |journal=IUBMB Life |volume=53 |issue= 1 |pages= 3-14 |year= 2002 |pmid= 12018405 |doi= }}
*{{cite journal | author=Di Fiore PP, Scita G |title=Eps8 in the midst of GTPases. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 10 |pages= 1178-83 |year= 2002 |pmid= 12127568 |doi= }}
*{{cite journal | author=Benaim G, Villalobo A |title=Phosphorylation of calmodulin. Functional implications. |journal=Eur. J. Biochem. |volume=269 |issue= 15 |pages= 3619-31 |year= 2002 |pmid= 12153558 |doi= }}
*{{cite journal | author=Leu TH, Maa MC |title=Functional implication of the interaction between EGF receptor and c-Src. |journal=Front. Biosci. |volume=8 |issue= |pages= s28-38 |year= 2004 |pmid= 12456372 |doi= }}
*{{cite journal | author=Anderson NL, Anderson NG |title=The human plasma proteome: history, character, and diagnostic prospects. |journal=Mol. Cell Proteomics |volume=1 |issue= 11 |pages= 845-67 |year= 2003 |pmid= 12488461 |doi= }}
*{{cite journal | author=Kari C, Chan TO, Rocha de Quadros M, Rodeck U |title=Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage. |journal=Cancer Res. |volume=63 |issue= 1 |pages= 1-5 |year= 2003 |pmid= 12517767 |doi= }}
*{{cite journal | author=Bonaccorsi L, Muratori M, Carloni V, ''et al.'' |title=Androgen receptor and prostate cancer invasion. |journal=Int. J. Androl. |volume=26 |issue= 1 |pages= 21-5 |year= 2003 |pmid= 12534934 |doi= }}
*{{cite journal | author=Reiter JL, Maihle NJ |title=Characterization and expression of novel 60-kDa and 110-kDa EGFR isoforms in human placenta. |journal=Ann. N. Y. Acad. Sci. |volume=995 |issue= |pages= 39-47 |year= 2003 |pmid= 12814937 |doi= }}
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}}
{{refend}}
end log.