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Transmembrane and ubiquitin-like domain-containing protein 2 is a protein that in humans is encoded by the TMUB2 gene.[1][2][3]
Gene
TMUB2 maps on the human chromosome 17, at locus 17q21.31.[3] TMUB2 sits between two neighboring genes, ASB16-AS1 to the left and ATXN7L3 to the right.[4] TMUB2 is 4.99Kb long. The TMUB2 gene can be transcribed into three possible mRNA variants.[5]
Expression
TMUB2 is likely ubiquitously expressed throughout the human body.[6] It has a high expression level that is 2.9 times higher than other human genes.[7][8]
Protein
The TMUB2 protein has a function that is not currently known. It consists of a 321 amino acid long chain in humans. The human protein has a molecular weight of 33.8kdal, an isoelectric point of 4.73899, and three transmembrane regions.[9] These will likely vary in orthologs.
Homology
Paralogs
TMUB1 is the only paralog of TMUB2.[10][11] These proteins share a 38% identity and 51% similarity.[12]
Orthologs
The table below presents a selection of some of the TMUB2 orthologs to display protein diversity among species.[12]
| Species | Common Name | Accession Number | Sequence Length (aa) | Sequence Identity | Sequence Similarity |
|---|---|---|---|---|---|
| Pan troglodytes | Chimpanzee | XP_003953053.1 | 301 | 100% | 100% |
| Felis Catus | Cat | XP_003997025.1 | 322 | 95% | 95% |
| Mus Musculus | Mouse | AAH29841.2 | 319 | 85% | 88% |
| Alligator Mississippiensus | Alligator | XP_006271613.1 | 306 | 61% | 71% |
| Haliaeetus leucocephalus | Bald Eagle | XP_010559728 | 301 | 59% | 70% |
| Danio rerio | Zebrafish | NP_001005573.1 | 291 | 47% | 60% |
| Acromyrmex echinatior | Ant | XP_011049429.1 | 354 | 23% | 42% |
| Nannochloropsis Gaditana* | Algae | EWM26843.1 | 476 | 41% | 54% |
| Coccidioides immitis RS* | Pathogenic Fungus | XP_001242306.1 | 418 | 38% | 50% |
*Limited Query Coverage
Protein Interactions
In humans, Ubiquitin C (UBC) is a protein with a known interaction with TMUB2.[13][14][15][16] Other proposed interactions include BCL2L13 (BCL2-like 13),[17] SGTA (Small glutamine-rich tetratricopeptide repeat-containing protein),[17] and UBQLN1 (Ubiquilin-1).[17][18][19]
References
- ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b "Entrez Gene: TMUB2 transmembrane and ubiquitin-like domain containing 2".
- ^ UCSC Genome Browser: BLAT Search
- ^ NCBI Gene: TMUB2
- ^ EST Profile Viewer: Human
- ^ Aceview: TMUB2
- ^ NCBI GEO Profiles
- ^ SDSC Biology Workbench 2.0
- ^ GeneCards: TMUB2
- ^ NCBI Gene: TMUB1
- ^ a b NCBI BLAST: Basic Local Alignment Search Tool
- ^ Danielsen, Jannie M R, Kathrine B Sylvestersen, Simon Bekker-Jensen, Damian Szklarczyk, Jon W Poulsen, Heiko Horn, Lars J Jensen, Niels Mailand, and Michael L Nielsen. “Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level.” Molecular & Cellular Proteomics : MCP 10 (2011): M110.003590. doi:10.1074/mcp.M110.003590.
- ^ Wagner, S. A., P. Beli, B. T. Weinert, M. L. Nielsen, J. Cox, M. Mann, and C. Choudhary. “A Proteome-Wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles.” Molecular & Cellular Proteomics, 2011. doi:10.1074/mcp.M111.013284.
- ^ Kim, Woong, Eric J. Bennett, Edward L. Huttlin, Ailan Guo, Jing Li, Anthony Possemato, Mathew E. Sowa, et al. “Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome.” Molecular Cell 44 (2011): 325–40. doi:10.1016/j.molcel.2011.08.025.
- ^ Povlsen, Lou K., Petra Beli, Sebastian A. Wagner, Sara L. Poulsen, Kathrine B. Sylvestersen, Jon W. Poulsen, Michael L. Nielsen, Simon Bekker-Jensen, Niels Mailand, and Chunaram Choudhary. “Systems-Wide Analysis of Ubiquitylation Dynamics Reveals a Key Role for PAF15 Ubiquitylation in DNA-Damage Bypass.” Nature Cell Biology, 2012. doi:10.1038/ncb2579.
- ^ a b c Rolland T, Taşan M, Charloteaux B, et al. A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-26. doi: 10.1016/j.cell.2014.10.050. PMID 25416956; PMC 4266588.
- ^ STRING: Functional Protein Association Networks
- ^ BioGRID Database
Further reading
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