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Thymidine kinase 2, mitochondrial is a protein that in humans is encoded by the TK2 gene. This gene encodes a deoxyribonucleoside kinase that specifically...

Thymidine kinase is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, EC 2.7.1.21. It can be...

Thymidine kinase 1, soluble (gene name TK1), is a human thymidine kinase. Two forms of this protein have been identified in animal cells, one in cytosol...

patient prognosis. Patients with mutations in the thymidine kinase gene may have a certain type of mitochondrial DNA depletion syndrome, a disease that leads...

insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes". Molecular...

Thymidine kinase is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, EC 2.7.1.21 that catalyzes...

Y, Eriksson S, Elpeleg O (November 2001). "Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy". Nature Genetics. 29 (3): 342–4...

includes deoxycytidine kinase (cytosolic) as well as the two mitochondrial enzymes deoxyguanosine kinase and thymidine kinase 2 in humans. The base specificity...

(June 2010). "Identification and characterization of mitochondrial factors modulating thymidine kinase 2 activity". Nucleosides, Nucleotides & Nucleic Acids...

The process begins with a treatment with thymidine, washing of the culture, followed by another thymidine treatment. Hydroxyurea decreases the production...

when this oxidized derivative of deoxyguanosine was inserted into the thymidine kinase gene in a chromosome within human lymphoblastoid cells in culture....

with the mitochondrial thymidine kinase, as part of the thymidine (dTTP)/dTMP substrate cycle. Since excess dTTP leads to aberrant mitochondrial DNA replication...

"Deoxyribonucleoside kinases in two aquatic bacteria with high specificity for thymidine and deoxyadenosine". FEMS Microbiology Letters. 331 (2): 120–7. doi:10...

Yamaguchi Y, et al. (1989). "Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography". Biochim...

(EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one...

the size of dNTP pools in cells, in conjunction with the cytosolic thymidine kinases, as part of the dNTP substrate cycle. The enzyme is ubiquitously expressed...

such as ATP or PRPP. Thymidine can be phosphorylated by thymidine kinase (TK). Uridine can be phosphorylated by uridine kinase (UK). Cytidine can be...

insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes". Mol...

This phosphorylation step is carried out by cellular kinase enzymes. NRTIs can induce mitochondrial impairment that leads to a number of adverse events...

affinity for zidovudine to thymidine kinase (the enzyme responsible for the first phosphorylation) is similar to that of thymidine, whereas the affinity for...