Glycosuria: Difference between revisions
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== History == |
== History == |
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The first clear reference to the condition which is now know as glycosuria was found in both ancient Indian and Chinese text.In [[Ayurveda|ayurvedic]] text glycosuria was referred as Madhumeha(honey urine) which is first observed when insects and files attract urine of the patients.<ref>{{Cite book |last=javanesegraviton |url=http://archive.org/details/CharakaSamhitaTextWithEnglishTanslationP.V.Sharma |title=Charaka Samhita Text With English Tanslation P. V. Sharma}}</ref>In china the term ''táng niǎo bìng was referred to as sugar urine disease.''<ref>{{Cite web |url=https://diabetesjournals.org/spectrum/article/14/3/154/640/Traditional-Chinese-Medicine-in-the-Treatment-of |access-date=2023-04-27 |website=diabetesjournals.org}}</ref>In 1674,[[Thomas Willis]] describes sweet taste in urine of diabetic patients in his work on Pharmaceutice rationalis.<ref>{{Cite book |last=Willis |first=Thomas |url=http://archive.org/details/b30323976 |title=Pharmaceutice rationalis: or, an exercitation of the operations of medicines in humane bodies. Shewing the signs, causes and cures of most distempers incident thereunto ... As also a treatise of the scurvy. And the several sorts thereof, with their symptoms, causes and cure ... |date=1679 |publisher=London : Printed for T. Dring, C. Harper, and J. Leigh, and are to be sold by R. Clavell |others=Wellcome Library}}</ref>The presence of sugar in the urine was demonstrated by many physicians including Robert Wyatt and [[Matthew Dobson (physician)|Matthew Dobson]] .<ref>{{Cite book |last=Dods |first=R. F. |url=https://books.google.co.in/books?id=0OH3FENH-o0C&pg=PA31&redir_esc=y |title=Understanding Diabetes: A Biochemical Perspective |date=2013-02-12 |publisher=Wiley |isbn=978-1-118-53076-4 |language=en}}</ref> |
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==References== |
==References== |
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Revision as of 07:12, 27 April 2023
| Glycosuria | |
|---|---|
| Other names | Glucosuria |
 | |
| Glucose | |
| Specialty | Endocrinology |
| Causes | Diabetes, dehydration |
Glycosuria is the excretion of glucose into the urine. Ordinarily, urine contains no glucose because the kidneys are able to reabsorb all of the filtered glucose from the tubular fluid back into the bloodstream. Glycosuria is nearly always caused by elevated blood glucose levels, most commonly due to untreated diabetes mellitus. Rarely, glycosuria is due to an intrinsic problem with glucose reabsorption within the kidneys (such as Fanconi syndrome), producing a condition termed renal glycosuria.[1] Glycosuria leads to excessive water loss into the urine with resultant dehydration, a process called osmotic diuresis.
Alimentary glycosuria is a temporary condition, when a high amount of carbohydrate is taken, it is rapidly absorbed in some cases where a part of the stomach is surgically removed, the excessive glucose appears in urine producing glycosuria.
Additionally, SGLT2 inhibitor medications ("gliflozins" or "flozins") produce glycosuria as their primary mechanism of action, by inhibiting sodium/glucose cotransporter 2 in the kidneys and thereby interfering with renal glucose reabsorption.
Follow-up
In a patient with glucosuria, diabetes is confirmed by measuring fasting or random plasma glucose and glycated hemoglobin(HbA1c).[2]
Pathophysiology
Blood is filtered by millions of nephrons, the functional units that comprise the kidneys. In each nephron, blood flows from the arteriole into the glomerulus, a tuft of leaky capillaries. The Bowman's capsule surrounds each glomerulus, and collects the filtrate that the glomerulus forms. The filtrate contains waste products (e.g. urea), electrolytes (e.g. sodium, potassium, chloride), amino acids, and glucose. The filtrate passes into the renal tubules of the kidney. In the first part of the renal tubule, the proximal tubule, glucose is reabsorbed from the filtrate, across the tubular epithelium and into the bloodstream. The proximal tubule can only reabsorb a limited amount of glucose (~375 mg/min[3]), known as the transport maximum. When the blood glucose level exceeds about 160–180 mg/dL (8.9-10 mmol/L), the proximal tubule becomes overwhelmed and begins to excrete glucose in the urine.
| Urine dipstick designation |
Approximate urine concentration |
|---|---|
| trace | 100 mg/dL [4] |
| 1+ | 250 mg/dL[4] df |
| 2+ | 500 mg/dL[4] |
| 3+ | 1000 mg/dL[4] |
| 4+ | 2000 mg/dL[4] |
This point is called the renal threshold for glucose (RTG).[5] Some people, especially children and pregnant women, may have a low RTG (less than ~7 mmol/L[5] glucose in blood to have glucosuria).
If the RTG is so low that even normal blood glucose levels produce the condition, it is referred to as renal glycosuria.
Glucose in urine can be identified by Benedict's qualitative test.
If yeast is present in the bladder, the sugar in the urine may begin to ferment, producing a rare condition known as urinary auto-brewery syndrome.
History
The first clear reference to the condition which is now know as glycosuria was found in both ancient Indian and Chinese text.In ayurvedic text glycosuria was referred as Madhumeha(honey urine) which is first observed when insects and files attract urine of the patients.[6]In china the term táng niǎo bìng was referred to as sugar urine disease.[7]In 1674,Thomas Willis describes sweet taste in urine of diabetic patients in his work on Pharmaceutice rationalis.[8]The presence of sugar in the urine was demonstrated by many physicians including Robert Wyatt and Matthew Dobson .[9]
References
- ^ Rose, Burton; Rennke, Helmut (1994). Renal pathophysiology – the essentials (1st ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 194. ISBN 0-683-07354-0.
- ^ Liman, Maria Nataly P.; Jialal, Ishwarlal (2022-03-18). "Physiology, Glycosuria". NCBI Bookshelf. PMID 32491373. Retrieved 2022-08-29.
- ^ DeFronzo, Ralph A.; Hompesch, Marcus; Kasichayanula, Sreeneeranj; Liu, Xiaoni; Hong, Ying; Pfister, Marc; Morrow, Linda A.; Leslie, Bruce R.; Boulton, David W. (October 2013). "Characterization of Renal Glucose Reabsorption in Response to Dapagliflozin in Healthy Subjects and Subjects With Type 2 Diabetes". Diabetes Care. 36 (10): 3169–3176. doi:10.2337/dc13-0387. ISSN 0149-5992. PMC 3781504. PMID 23735727.
- ^ a b c d e Han BR, Oh YS, Ahn KH, Kim HY, Hong SC, Oh MJ, Kim HJ, Kim YT, Lee KW, Kim SH. BR, Han (Sep 2010). "Clinical Implication of 2nd Trimester Glycosuria". Korean J Perinatol. 21 (3): 258–65. [1] [2][permanent dead link]
- ^ a b AIDA on-line' Explanations
- ^ javanesegraviton. Charaka Samhita Text With English Tanslation P. V. Sharma.
- ^ diabetesjournals.org https://diabetesjournals.org/spectrum/article/14/3/154/640/Traditional-Chinese-Medicine-in-the-Treatment-of. Retrieved 2023-04-27.
{{cite web}}: Missing or empty|title=(help) - ^ Willis, Thomas (1679). Pharmaceutice rationalis: or, an exercitation of the operations of medicines in humane bodies. Shewing the signs, causes and cures of most distempers incident thereunto ... As also a treatise of the scurvy. And the several sorts thereof, with their symptoms, causes and cure ... Wellcome Library. London : Printed for T. Dring, C. Harper, and J. Leigh, and are to be sold by R. Clavell.
- ^ Dods, R. F. (2013-02-12). Understanding Diabetes: A Biochemical Perspective. Wiley. ISBN 978-1-118-53076-4.