RCOR1

RCOR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IW5, 2UXN, 2UXX, 2V1D, 2X0L, 2XAF, 2XAG, 2XAH, 2XAJ, 2XAQ, 2XAS, 2Y48, 3ZMS, 3ZMT, 3ZMU, 3ZMV, 3ZMZ, 3ZN0, 3ZN1, 4BAY, 4KUM, 4UV8, 4UV9, 4UVA, 4UVB, 4UVC, 4UXN, 5L3D, 5L3B, 5L3C, 4XBF
Identifiers
Aliases	RCOR1, COREST, RCOR, REST corepressor 1
External IDs	OMIM: 607675; MGI: 106340; HomoloGene: 32246; GeneCards: RCOR1; OMA:RCOR1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	102,730,561 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	111,082,335 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gums; ; bone marrow; ; palpebral conjunctiva; ; bone marrow cells; ; jejunal mucosa; ; human penis; ; monocyte; ; oral cavity; ; lower lobe of lung;
	Top expressed in
	hair follicle; ; epithelium of stomach; ; left lung lobe; ; left colon; ; atrium; ; crypt of lieberkuhn of small intestine; ; Paneth cell; ; saccule; ; skin of abdomen; ; conjunctival fornix;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; transcription factor binding; histone deacetylase activity; transcription corepressor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	DNA repair complex; transcription repressor complex; nucleus; transcription regulator complex; nucleoplasm;
Biological process	histone H4 deacetylation; viral process; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; blood coagulation; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; chromatin organization; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	23186
	217864
	ENSG00000089902
	ENSMUSG00000037896
	Q9UKL0
	Q8CFE3
	NM_015156
	NM_198023
	NP_055971
	NP_932140
	Wikidata
View/Edit Human	View/Edit Mouse

REST corepressor 1 also known as CoREST is a protein that in humans is encoded by the RCOR1 gene.^[5]^[6]

Function

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).^[6]

Interactions

RCOR1 has been shown to interact with

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089902 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037896 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Andrés ME, Burger C, Peral-Rubio MJ, Battaglioli E, Anderson ME, Grimes J, Dallman J, Ballas N, Mandel G (September 1999). "CoREST: a functional corepressor required for regulation of neural-specific gene expression". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9873–8. Bibcode:1999PNAS...96.9873A. doi:10.1073/pnas.96.17.9873. PMC 22303. PMID 10449787.
^ ^a ^b "Entrez Gene: RCOR1 REST corepressor 1".
^ ^a ^b ^c ^d Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. Bibcode:2002PNAS...99.7420H. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
^ ^a ^b You A, Tong JK, Grozinger CM, Schreiber SL (February 2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1454–8. Bibcode:2001PNAS...98.1454Y. doi:10.1073/pnas.98.4.1454. PMC 29278. PMID 11171972.
^ Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.

Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Grimes JA, Nielsen SJ, Battaglioli E, Miska EA, Speh JC, Berry DL, Atouf F, Holdener BC, Mandel G, Kouzarides T (2000). "The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex". J. Biol. Chem. 275 (13): 9461–7. doi:10.1074/jbc.275.13.9461. PMID 10734093.
Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH (2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1". J. Biol. Chem. 276 (9): 6817–24. doi:10.1074/jbc.M007372200. PMID 11102443.
You A, Tong JK, Grozinger CM, Schreiber SL (2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1454–8. Bibcode:2001PNAS...98.1454Y. doi:10.1073/pnas.98.4.1454. PMC 29278. PMID 11171972.
Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G (2001). "Regulation of neuronal traits by a novel transcriptional complex". Neuron. 31 (3): 353–65. doi:10.1016/S0896-6273(01)00371-3. PMID 11516394.
Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. Bibcode:2002PNAS...99.7420H. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
Battaglioli E, Andrés ME, Rose DW, Chenoweth JG, Rosenfeld MG, Anderson ME, Mandel G (2002). "REST repression of neuronal genes requires components of the hSWI.SNF complex". J. Biol. Chem. 277 (43): 41038–45. doi:10.1074/jbc.M205691200. PMID 12192000.
Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G, Rosenfeld MG (2002). "Corepressor-dependent silencing of chromosomal regions encoding neuronal genes". Science. 298 (5599): 1747–52. Bibcode:2002Sci...298.1747L. CiteSeerX 10.1.1.136.7131. doi:10.1126/science.1076469. PMID 12399542. S2CID 13507921.
Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.
Gu H, Liang Y, Mandel G, Roizman B (2005). "Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7571–6. Bibcode:2005PNAS..102.7571G. doi:10.1073/pnas.0502658102. PMC 1140450. PMID 15897453.
Lee MG, Wynder C, Cooch N, Shiekhattar R (2005). "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation". Nature. 437 (7057): 432–5. Bibcode:2005Natur.437..432L. doi:10.1038/nature04021. PMID 16079794. S2CID 4396351.
Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y (2005). "Regulation of LSD1 histone demethylase activity by its associated factors". Mol. Cell. 19 (6): 857–64. doi:10.1016/j.molcel.2005.08.027. PMID 16140033.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000089902 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037896 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10449787-5] Andrés ME, Burger C, Peral-Rubio MJ, Battaglioli E, Anderson ME, Grimes J, Dallman J, Ballas N, Mandel G (September 1999). "CoREST: a functional corepressor required for regulation of neural-specific gene expression". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9873–8. Bibcode:1999PNAS...96.9873A. doi:10.1073/pnas.96.17.9873. PMC 22303. PMID 10449787.

[entrez-6] "Entrez Gene: RCOR1 REST corepressor 1".

[pmid12032298-7] Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. Bibcode:2002PNAS...99.7420H. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.

[pmid11171972-8] You A, Tong JK, Grozinger CM, Schreiber SL (February 2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1454–8. Bibcode:2001PNAS...98.1454Y. doi:10.1073/pnas.98.4.1454. PMC 29278. PMID 11171972.

[pmid15325272-9] Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.

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v t e Transcription coregulators
Coactivators	ARA (54, 55, 70) BCAS3 CARM1 p300-CBP (EP300, CREBBP) CRTC (1, 2, 3) DRIP/TRAP (MED1 Drip205/Trap220) MN1 PCAF PNRC (1, 2) PPARGC (1A, 1B) TGFB1I1 NCOA1 (SRC-1) NCOA2 (GRIP1/SRC-2/TIF2) NCOA3 (AIB/SRC-3/TRAM-1) NCOA4 (ARA70) NCOA5 (CIA) NCOA6 (RAP250) NCOA7 (ERAP140)
Corepressors	CTBP (1, 2) Hairless homolog LCOR NRIP1 (RIP140) PELP-1 RCOR1 Rb SIN3A SIN3B Tripartite motif family TRIM (24, 28, 33) NCOR1 NCOR2 (SMRT)
ATP-dependent remodeling factors	Chromatin Structure Remodeling (RSC) Complex SWI/SNF

Function

Interactions

References

Further reading