Pterulone
Appearance
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Names | |
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Preferred IUPAC name
1-[(3Z)-3-(Chloromethylidene)-2,3-dihydro-1-benzoxepin-7-yl]ethan-1-one | |
Identifiers | |
3D model (JSmol)
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PubChem CID
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Properties | |
C13H11ClO2 | |
Molar mass | 234.678 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Pterulone is a fungal metabolite. It was initially isolated from the mycelium and liquid cultures of wood-decay fungus in the genus Pterula. The compound inhibits eukaryotic respiration by targeting the mitochondrial NADH:ubiquinone oxidoreductase.[1]
References
- ^ Engler M, Anke T, Sterner O, Brandt U (1997). "Pterulinic acid and pterulone, two novel inhibitors of NADH:ubiquinone oxidoreductase (complex I) produced by a Pterula species. I. Production, isolation and biological activities". Journal of Antibiotics. 50 (4): 325–9. doi:10.7164/antibiotics.50.325. PMID 9186558.