Pentafluorophenol
Appearance
![]() | |
Names | |
---|---|
Preferred IUPAC name
Pentafluorophenol | |
Identifiers | |
3D model (JSmol)
|
|
ChemSpider | |
ECHA InfoCard | 100.011.123 |
EC Number |
|
PubChem CID
|
|
UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
Properties | |
C6F5OH | |
Molar mass | 184.065 g·mol−1 |
Appearance | white solid or colorless liquid |
Melting point | 32.8 °C (91.0 °F; 305.9 K) |
Boiling point | 145.6 °C (294.1 °F; 418.8 K) |
Hazards | |
GHS labelling: | |
![]() ![]() | |
Danger | |
H302, H312, H314, H315, H319, H335 | |
P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
Pentafluorophenol is the organofluorine compound (specifically a fluoroalcohol) with the formula C6F5OH. This is the perfluorinated analogue of phenol. It is a white odorless solid that melts just above room temperature. With a pKa of 5.5, it is one of the most acidic phenols.
Uses
Pentafluorophenol is used to prepare pentafluorophenyl esters, which are active esters useful in peptide synthesis.[1]
Environmental hazards
Pentafluorophenol is considered hazardous because of oral, dermal and inhalation toxicity and because it causes severe skin burns and eye damage.[2][3]
References
- ^ Jones K, DeAmicis C (2009). "Pentafluorophenol". Encyclopedia of Reagents for Organic Synthesis. pp. 1–9. doi:10.1002/047084289X. hdl:10261/236866.
- ^ "Pentafluorophenol SAFETY DATA SHEET". Thermo Fisher Scientific. January 18, 2018. Retrieved 26 February 2021.
- ^ "Pentafluorophenol". PubChem. National Center for Biotechnology Information. February 20, 2021. Retrieved 26 February 2021.