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connexin subunits. Pannexin 1 and pannexin 2 underlie channel function in neurons and contribute to ischemic brain damage. Pannexin 1 has been shown to...

Pannexin 1 is a protein in humans that is encoded by the PANX1 gene. The protein encoded by this gene belongs to the innexin family. Innexin family members...

reducing its deposition in various tissues. Probenecid also inhibits pannexin 1. Pannexin 1 is involved in the activation of inflammasomes and subsequent release...

"Cell-to-cell communication in intact taste buds through ATP signalling from pannexin 1 gap junction hemichannels". The Journal of Physiology. 587 (Pt 24): 5899–906...

odontoblast-neuron signal communication via Piezo1/TRPA1 channels and pannexin-1 in odontoblasts and P2X3 receptors in A-delta neuron is involved in the...

signaling. Spironolactone has been found to act as a potent inhibitor of the pannexin 1 channel, and this action appears to be involved in its antihypertensive...

beaded apoptopodia (the latter having a beads-on-a-string appearance). Pannexin 1 is an important component of membrane channels involved in the formation...

regulator (CFTR), and a final conduit that transport ATP to vascular lumen (pannexin 1 or voltage-dependent anion channel (VDAC)). The released ATP acts on purinergic...

case, the final product of the hydrolysis cascade is the nucleoside. The Pannexin-1 channel (PANX1) is an integral component of the P2X/P2Y purinergic signaling...

intracellular environment. Purinergic and NMDA receptors activate the pannexin-1 channels, which become hyperactive and allow the release of ATP from the...

slow with a time constant of about 200 ms and depends on ATP release via Pannexin 1 channels located on horizontal cell dendrites invaginating the cone synaptic...

called "pannexins" (from the Greek pan - all, throughout, and Latin nexus - connection, bond). However, increasing evidence suggests that pannexins do not...

Locovei S, Dahl G (September 2008). "Probenecid, a gout remedy, inhibits pannexin 1 channels". American Journal of Physiology. Cell Physiology. 295 (3): C761–7...

Brant E.; Bayliss, Douglas A.; Ravichandran, Kodi S. (October 2010). "Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during...

one-half of a gap junction channel. Hemichannels consist of connexins. Pannexins are involved in the process of purinergic signalling. They release adenosine...

Fátima; Silva-Ramos, Miguel; Correia-de-Sá, Paulo (2014). "ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6...

Furthermore, pannexins appear to do this to such an extent they may rarely if ever participate in direct cell to cell coupling. As indicated on the pannexin/innexin/connexin...

in vivo in the same way connexins do. The more recently characterized pannexin family, which was originally thought to form intercellular channels (with...

by MITF. Activation of the P2X7 receptor by ATP leads to recruitment of pannexin pores which allow small molecules such as ATP to leak out of cells. This...

multilevel platform via which connexins and pannexins can influence the following cellular functions within a tissue: (1) connexin gap junctional channels (GJCs)...