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There is a page named "PROTAC" on Wikipedia
- Proteolysis targeting chimera (redirect from PROTAC)chimera (PROTAC) is a molecule that can remove specific unwanted proteins. Rather than acting as a conventional enzyme inhibitor, a PROTAC works by inducing...15 KB (1,560 words) - 07:10, 2 August 2024
- initial work focused on the discovery of PROteolysis-TArgeting Chimeras (PROTACs) to trigger degradation of disease-causing proteins, a process known as...31 KB (2,873 words) - 05:59, 14 July 2024
- operating companies in France, Italy, and the UK, working with Bayern-Chemie/Protac in Germany, Inmize Sistemas SL in Spain, and Saab Bofors Dynamics in Sweden...80 KB (9,666 words) - 04:44, 23 August 2024
- of PROTACs, which consist of a heterobifunctional molecule with a ligand of an E3 ubiquitin ligase linked to a ligand of a target protein. PROTACs are...22 KB (2,507 words) - 06:46, 20 August 2024
- proteolysis-targeting chimera or PROTAC and its therapeutic potential. Recruitment of an E3 ligase to the target protein by the PROTAC is a critical step in the...12 KB (1,087 words) - 14:32, 22 August 2024
- Pulses". Economic Botany. 61 (1): 108. doi:10.1663/0013-0001(2007)61[108a:PROTAC]2.0.CO;2. ISSN 0013-0001. S2CID 198156564. McLelland, Jonathan (4 December...51 KB (5,764 words) - 10:50, 21 August 2024
- the pool of potential protein targets. Proteolysis-targeting chimeras (PROTACs) were first reported by Kathleen Sakamoto, Craig Crews, and Raymond Deshaies...21 KB (2,210 words) - 09:26, 1 January 2024
- SHR9549: Jiangsu Hengrui Vepdegestrant (ARV-471): Oral estrogen receptor PROTAC protein degrader for breast cancer by Arvinas. ZB716 (Fulvestrant boronic...5 KB (445 words) - 13:38, 18 August 2024
- conceived the idea of using heterobifunctional small molecules, referred to as PROTACs, to tether cellular proteins to a ubiquitin ligase, resulting in ubiquitination...18 KB (2,482 words) - 05:06, 15 February 2024
- Elizabeth; Chen, Xin; Haskell, Roy; Lin, Eva (2022-11-10). "Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers"...38 KB (3,947 words) - 18:18, 28 June 2024
- Brd4, Brd4-BD2 L387A, that can be highly selectively bound by tag-specific PROTAC degrader AGB1 to form a ternary complex between the "BromoTagged" protein...24 KB (2,673 words) - 17:55, 22 July 2024
- heterobifunctional (two-sided) synthetic small molecules such as dimerizers or PROTACs bring two proteins together inside cells, which can synthetically induce...55 KB (6,095 words) - 00:47, 20 August 2024
- using the novel drug modality of proteolysis-targeting-chimeras (PROTACs). PROTACs are heterobifunctional small molecules that are designed to interact...63 KB (6,157 words) - 16:00, 30 March 2024
- profiling enables high-throughput screening for PROteolysis TArgeting Chimera (PROTAC) phenotypic signature". doi:10.1101/2022.01.17.476610. Retrieved 2023-08-13...10 KB (1,039 words) - 04:36, 29 July 2024
- proteins of interest. These molecules, termed proteolysis targeting chimeras (PROTACs) or protein degraders, recruit CRBN to a protein of interest, leading to...12 KB (1,350 words) - 18:12, 22 April 2024
- assessing ternary complex formation. An example for such modulators are PROTACs, which are investigated for their therapeutic potential in cancer therapy...35 KB (4,515 words) - 07:57, 6 August 2024
- for gene therapy . These discoveries led Steve Crews at Yale to develop PROTACS for the selective degradation of therapeutic targets. More recently, Crabtree...23 KB (2,732 words) - 21:32, 28 June 2024
- Zhang Z, Wang J, Shen Z (January 2021). "Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges". Eur...14 KB (1,217 words) - 08:59, 1 August 2024
- analog of the ERK5 inhibitor BAY-885 the Proteolysis Targeting Chimera (PROTAC) INY-06-061 was developed which allows to compare the phenotypes resulting...17 KB (1,955 words) - 04:28, 19 November 2023
- and new ligands that expand the scope of proteolysis targeting chimeras (PROTACS), which are bifunctional molecules that harness the cells ubiquitin-proteasome...13 KB (1,161 words) - 00:36, 7 August 2024