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There is a page named "PDE5 drug design" on Wikipedia
- Sildenafil, the first PDE5 inhibitor, was discovered through rational drug design programme. The compound was potent and selective over PDE5 but was lacking...42 KB (4,750 words) - 14:46, 13 July 2024
CGMP-specific phosphodiesterase type 5 (redirect from PDE5)shown that tadalafil is more selective for PDE5 over PDE6 than sildenafil or vardenafil. PDE5 drug design PDE5 inhibitor Phosphodiesterase Icariin GRCh38:...16 KB (1,849 words) - 14:58, 23 May 2024
Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge...44 KB (5,022 words) - 12:03, 26 July 2024- prefrontal regions. Testosterone is also proposed to be coupled with the PDE5 inhibitor, targeting an insensitive system for the production of sexual desire...36 KB (3,872 words) - 15:23, 22 August 2024
- Drug nomenclature is the systematic naming of drugs, especially pharmaceutical drugs. In the majority of circumstances, drugs have 3 types of names: chemical...26 KB (2,150 words) - 07:07, 12 June 2024
treatment for erectile dysfunction. However, the drug can inhibit PDE6 in retina (albeit with less affinity than PDE5). This has been shown to result in loss of...11 KB (1,122 words) - 01:24, 20 February 2024
augmenting with bupropion or adding a PDE5 Inhibitor have decreased symptoms of sexual dysfunction. Studies have shown that PDE5 Inhibitors, such as sildenafil...78 KB (7,687 words) - 09:12, 6 April 2024
Designer drugs are structural or functional analogues of controlled substances that are designed to mimic the pharmacological effects of the parent drug while...67 KB (8,048 words) - 00:52, 10 August 2024
Ritonavir (category Drug has EMA link)blood concentration of phenobarbital, primidone, carbamazepine, phenytoin, PDE5 inhibitors like sildenafil, opioids such as hydrocodone, oxycodone, pethidine...42 KB (3,598 words) - 14:41, 6 August 2024- Icos (section Miscellaneous drugs)pulmonary arterial hypertension (PAH). It is a phosphodiesterase type 5 (PDE5) inhibitor, similar in function to sildenafil. In addition to ED and PAH...42 KB (4,395 words) - 21:23, 16 August 2024
List of polysubstance combinations (redirect from List of drug combinations)smoking "Drug Combinations". combo.tripsit.me. "Erowid Drug Slang & Terminology Vault : A - B". erowid.org. Copping, Jasper (8 November 2009). "Drug slang:...29 KB (1,001 words) - 06:09, 21 August 2024
Simmerafil (category PDE5 inhibitors)Simmerafil (TPN171H) is a selective PDE5 inhibitor in development for the treatment of erectile dysfunction and pulmonary hypertension. Odilov, Abdullajon;...5 KB (221 words) - 13:07, 5 August 2024
Injection (medicine) (redirect from Injectable drug)injections of alprostadil may be used by people for whom other treatments such as PDE5 inhibitors are ineffective or contraindicated. Other medications may also...48 KB (5,650 words) - 16:49, 5 May 2024
Riociguat (category Drugs with non-standard legal status)inhibitors (including PDE5 inhibitors) increase the hypotensive (blood pressure lowering) effect of riociguat. Combining such drugs is therefore contraindicated...21 KB (2,122 words) - 07:28, 10 August 2024- instances, medication-based therapies are used, specifically PDE5 inhibitors like sildenafil. These drugs function by dilating blood vessels, facilitating increased...67 KB (7,128 words) - 02:23, 19 August 2024
- Biological functions of nitric oxide (category Infobox drug articles with non-default infobox title)tissue. Sildenafil (Viagra) works to inhibit the enzyme phosphodiesterase PDE5, which increases the cGMP concentration by inhibiting the conversion to GMP...70 KB (7,668 words) - 07:22, 6 August 2024
Management strategies include: for erectile dysfunction the addition of a PDE5 inhibitor such as sildenafil; for decreased libido, possibly adding or switching...129 KB (14,095 words) - 02:20, 19 August 2024
Crisaborole (category Drugs with non-standard legal status)PF-06930164. The drug was assumed to be potential $2bn-a-year blockbuster, when Pfizer acquired Anacor Pharmaceuticals. However, the drug was commercially...11 KB (942 words) - 05:41, 18 July 2024
Orally disintegrating tablet (category Food and Drug Administration)prescription. Tablets designed to dissolve on the buccal (cheek) mucous membrane were a precursor to the ODT. This dosage form was intended for drugs that yield...28 KB (1,673 words) - 23:09, 21 July 2024
it is the main ingredient of Semtex. PETN is also used as a vasodilator drug to treat certain heart conditions, such as for management of angina. Pentaerythritol...34 KB (3,324 words) - 09:30, 15 August 2024
- randomized prospective controlled trial to demonstrate the utility of a PDE5 inhibitor as a rehabilitation strategy in the prostate cancer radiation therapy