NETO1

NETO1
Identifiers
Aliases	NETO1, BCTL1, BTCL1, neuropilin and tolloid like 1
External IDs	OMIM: 607973; MGI: 2180216; HomoloGene: 16367; GeneCards: NETO1; OMA:NETO1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	72,868,146 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	86,506,718 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; caudate nucleus; ; putamen; ; nucleus accumbens; ; right frontal lobe; ; testicle; ; amygdala;
	Top expressed in
	dorsal striatum; ; dentate gyrus of hippocampal formation granule cell; ; nucleus accumbens; ; subiculum; ; olfactory tubercle; ; hippocampus proper; ; superior frontal gyrus; ; amygdala; ; visual cortex; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	ionotropic glutamate receptor binding;
Cellular component	integral component of membrane; extracellular region; cell junction; postsynaptic membrane; plasma membrane; synapse; excitatory synapse; membrane; postsynaptic density; postsynaptic density membrane; glutamatergic synapse; integral component of postsynaptic density membrane;
Biological process	visual learning; regulation of neuronal synaptic plasticity; receptor localization to synapse; regulation of long-term neuronal synaptic plasticity; memory; positive regulation of excitatory postsynaptic potential; regulation of kainate selective glutamate receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	81832
	246317
	ENSG00000166342
	ENSMUSG00000050321
	Q8TDF5
	Q8R4I7
NM_001201465; NM_138966; NM_138999; NM_153181; NM_001354017;
	NM_001354018; NM_001354020; NM_001354021; NM_001354022
	NM_144946; NM_001360910
NP_001188394; NP_620416; NP_620552; NP_001340946; NP_001340947;
	NP_001340949; NP_001340950; NP_001340951
	NP_659195; NP_001347839
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropilin (NRP) and tolloid (TLL)-like 1 is a protein that in humans is encoded by the NETO1 gene.^[5]

Function

This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166342 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050321 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Neuropilin (NRP) and tolloid (TLL)-like 1".

Ng D, Pitcher GM, Szilard RK, Sertié A, Kanisek M, Clapcote SJ, Lipina T, Kalia LV, Joo D, McKerlie C, Cortez M, Roder JC, Salter MW, McInnes RR (February 2009). "Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning". PLOS Biology. 7 (2): e41. doi:10.1371/journal.pbio.1000041. PMC 2652390. PMID 19243221.
Banno M, Koide T, Aleksic B, Yamada K, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Ikeda M, Inada T, Yoshikawa T, Iwata N, Ozaki N (2011). "A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population". PLOS ONE. 6 (12): e28929. Bibcode:2011PLoSO...628929B. doi:10.1371/journal.pone.0028929. PMC 3243668. PMID 22205981.
Stöhr H, Berger C, Fröhlich S, Weber BH (March 2002). "A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain". Gene. 286 (2): 223–31. doi:10.1016/s0378-1119(02)00438-9. PMID 11943477.
Benjamin DJ, Cesarini D, van der Loos MJ, Dawes CT, Koellinger PD, Magnusson PK, Chabris CF, Conley D, Laibson D, Johannesson M, Visscher PM (May 2012). "The genetic architecture of economic and political preferences" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 109 (21): 8026–31. Bibcode:2012PNAS..109.8026B. doi:10.1073/pnas.1120666109. PMC 3361436. PMID 22566634.
O'Donnell L, Soileau B, Heard P, Carter E, Sebold C, Gelfond J, Hale DE, Cody JD (August 2010). "Genetic determinants of autism in individuals with deletions of 18q". Human Genetics. 128 (2): 155–64. doi:10.1007/s00439-010-0839-y. PMID 20499253. S2CID 23659069.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166342 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050321 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Neuropilin (NRP) and tolloid (TLL)-like 1".

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Function

References

Further reading