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N-Terminal domain antiandrogens are a novel type of antiandrogen that bind to the N-terminal domain of the androgen receptor (AR) instead of the ligand-binding...

Ralaniten (developmental code name EPI-002) is an N-terminal domain antiandrogen which was never marketed. It is a derivative of bisphenol A and one of...

Antiandrogens, also known as androgen antagonists or testosterone blockers, are a class of drugs that prevent androgens like testosterone and dihydrotestosterone...

developmental code name EPI-7386, is an N-terminal domain antiandrogen, or antagonist of the N-terminal domain (NTD) of the androgen receptor (AR), which...

Selective androgen receptor modulator N-Terminal domain antiandrogen Discovery and development of antiandrogens Nonsteroidal estrogen Kolvenbag, Geert...

inhibitor of the androgen receptor amino-terminal domain Ralaniten (EPI-002), an N-terminal domain antiandrogen which was never marketed This set index...

The first antiandrogen was discovered in the 1960s. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone...

(developmental code name EPI-506) is a first-in-class antiandrogen that targets the N-terminal domain (NTD) of the androgen receptor (AR) developed by ESSA...

nilutamide, bicalutamide, enzalutamide, apalutamide, RU-58841) N-Terminal domain antiandrogens (e.g., bisphenol A, EPI-001, ralaniten, JN compounds) The AR...

antagonists to have been developed thus far. Cyanonilutamide N-Terminal domain antiandrogen de Jesus Cortez F, Nguyen P, Truillet C, Tian B, Kuchenbecker...

Efforts are underway to assess ERX-11 in human clinical trials. N-Terminal domain antiandrogen Raj GV, Sareddy GR, Ma S, Lee TK, Viswanadhapalli S, Li R, et al...

is different from all currently-used antiandrogens, which, conversely, bind to the C-terminal ligand-binding domain (LBD) of the AR and competitively block...

(pharmacodynamics, pharmacokinetics, and routes of administration) of the steroidal antiandrogen and progestin medication cyproterone acetate. CPA blocks the effects...

the pharmacodynamic and pharmacokinetic properties of the nonsteroidal antiandrogen (NSAA) bicalutamide. In terms of pharmacodynamics, bicalutamide acts...

various interaction partners of the ARM domains. The segments N-terminal and far C-terminal to the ARM domain do not adopt any structure in solution by...

identified by Wanker et al. in 1997. HIP1 was found to bind to Htt in an N-terminal dependent manner, and co-localise with Htt in the CNS although the nature...

anti-CEA antibody – anti-idiotype vaccine – anti-inflammatory – antiandrogen – antiandrogen therapy – anti-angiogenesis – antiangiogenic – antibody – antibody...

of hCG have also been detected, including nicked hCG, hCG missing the C-terminal peptide from the beta-subunit, and free alpha-subunit, which has no known...

around a central pore. Each subunit comprises four transmembrane domains with both the N- and C-terminus located extracellularly. The receptor sits in the...

SHBG has two laminin G-like domains which form pockets that bind hydrophobic molecules. The steroids are bound by the LG domain at the amino end of the protein...