N-acetylglucosamine kinase
N-acetylglucosamine kinase | |||||||||
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![]() N-acetylglucosamine kinase dimer, Thermotoga maritima | |||||||||
Identifiers | |||||||||
EC no. | 2.7.1.59 | ||||||||
CAS no. | 9027-48-9 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a N-acetylglucosamine kinase (EC 2.7.1.59) is an enzyme that catalyzes the chemical reaction
- ATP + N-acetyl-D-glucosamine ADP + N-acetyl-D-glucosamine 6-phosphate
Thus, the two substrates of this enzyme are ATP and N-acetyl-D-glucosamine, whereas its two products are ADP and N-acetyl-D-glucosamine 6-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-acetyl-D-glucosamine 6-phosphotransferase. Other names in common use include acetylglucosamine kinase (phosphorylating), ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase, 2-acetylamino-2-deoxy-D-glucose kinase, and acetylaminodeoxyglucokinase. This enzyme participates in glutamate metabolism and aminosugars metabolism.
References
- Asensio C, Ruiz-Amil M (1966). "[76b] N-acetyl-d-glucosamine kinase". N-Acetyl-D-glucosamine kinase. II. Escherichia coli. Methods Enzymol. Vol. 9. pp. 421–425. doi:10.1016/0076-6879(66)09086-4. ISBN 978-0-12-181809-8.
- Barkulis SS (1966). "[76a] N-Acetyl-d-glucosamine kinase". N-Acetyl-D-glucosamine kinase. I. Streptococcus pyogenes. Methods Enzymol. Vol. 9. pp. 415–420. doi:10.1016/0076-6879(66)09085-2. ISBN 978-0-12-181809-8.
- Datta A (October 1970). "Studies on hog spleen N-acetylglucosamine kinase. I. Purification and properties of N-acetylglucosamine kinase". Biochimica et Biophysica Acta. 220 (1): 51–60. doi:10.1016/0005-2744(70)90228-7. PMID 4319609.