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A mutant protein is the protein product encoded by a gene with mutation. Mutated protein can have single amino acid change (minor, but still in many cases...

mutations caused by mutagens. Scientists may also deliberately introduce mutant sequences through DNA manipulation for the sake of scientific experimentation...

protein results in an abnormal mutant protein (mHtt), which gradually damages brain cells through a number of possible mechanisms. The mutant protein...

usually designate hybrid proteins made of polypeptides having different functions or physico-chemical patterns. Chimeric mutant proteins occur naturally when...

independent of the original binding pair. This is done by taking a mutant protein (naturally occurring or selectively engineered), which is activated...

abundance of the fusion protein will decrease much faster than that of the unaltered protein. Second, a mutant form of the degron's protein is designed such...

of abnormal proteins which are called tumor-associated antigens. Other examples include tissue differentiation antigens, mutant protein antigens, oncogenic...

A mutein is a mutant protein, with an altered amino acid sequence that differs from that of the original wild-type protein. The word is a portmanteau of...

of mutant proteins must be screened to determine which mutants show enhanced properties. Phage display methods are one option for screening proteins. This...

and (2) the neuron's exposure to diffuse intracellular mutant huntingtin protein. NIIs (protein clumping) can be helpful as a coping mechanism—and not...

In biochemistry, a protein dimer is a macromolecular complex or multimer formed by two protein monomers, or single proteins, which are usually non-covalently...

stability of the wild-type protein are compared with those of point mutants to find phi values. These measure the mutant residue's energetic contribution...

DNA mutations are deliberately engineered to produce libraries of mutant genes, proteins, strains of bacteria, or other genetically modified organisms. The...

trinucleotide repeat is present within the protein-coding region, the repeat expansion leads to production of a mutant protein with gain of function. This is the...

Yellow fluorescent protein (YFP) is a genetic mutant of green fluorescent protein (GFP) originally derived from the jellyfish Aequorea victoria. Its excitation...

polypeptide chain. Protein complexes are a form of quaternary structure. Proteins in a protein complex are linked by non-covalent protein–protein interactions...

next stage of cell division. A mutant p53 will no longer bind DNA in an effective way, and, as a consequence, the p21 protein will not be available to act...

FS (June 2011). "Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells". Science Translational...

chaperone protein, it facilitates the proper folding of newly translated and misfolded proteins, as well as stabilize or degrade mutant proteins. In addition...

or degrade mutant proteins. Its functions contribute to biological processes including signal transduction, apoptosis, autophagy, protein homeostasis...