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instances. MeCP2 has been implicated in regulation of imprinted genes and loci that include UBE3A and DLX5. Reduced expression of MECP2 in Mecp2+/- neural...

and neuroanatomical correlates of MeCP2-deficiency. Recently (2008), it was shown that the conditional deletion of Mecp2 in catecholaminergic neurons (by...

of M2DS is a duplication of the MECP2 or Methyl CpG binding protein 2 gene located on the X chromosome (Xq28). The MeCP2 protein plays a pivotal role in...

leads to the phosphorylation of MeCP2, which results in a decrease in the binding of MeCP2 to BDNF promoter IV. Because MeCP2 can no longer bind to the BDNF...

suppression of gene expression. Stress-dependent phosphorylation of MeCP2 causes MeCP2 to dissociate from the promoter region of a gene called arginine vasopressin...

for unmethylated DNA. In vitro foot-printing with the chromosomal protein MeCP2 showed that the MBD could protect a 12 nucleotide region surrounding a methyl...

"Autism and other neuropsychiatric symptoms are prevalent in individuals with MeCP2 duplication syndrome". Annals of Neurology. 66 (6): 771–782. doi:10.1002/ana...

methylation states of genes such as MECP2 and EGR2 have been shown to play a role in autism and autism spectrum disorders. MECP2 abnormalities have been shown...

1999, a postdoctoral researcher in Zoghbi's lab identified MECP2 as the causative gene. The MECP2 protein binds methylated cytosine (5-methylcytosine) in...

Ketamine, as well as the epigenetic regulation of synaptic transmission by MeCP2. Monteggia pursued her undergraduate education at the University of Illinois...

epigenetic markers. Methyl-CpG-binding protein 2 (MeCP2) is a protein that binds to methylated DNA. MeCP2 has been found to associate most strongly with...

NPCs, and by MeCP2 and methylation of the L1 5' UTR. Human cell lines modeling the neurological disorder Rett syndrome, which carry MeCP2 mutations, exhibit...

is very important. In particular, loss of methyl-CpG-binding protein 2 (MeCP2) has been implicated in Rett syndrome; and methyl-CpG-binding domain protein...

to hmC appears to disrupt the binding of 5mC-binding proteins including MECP2 and MBD (Methyl-CpG-binding domain) proteins, facilitating nucleosome remodeling...

The genetic defect of the transcriptional regulator MECP2 is responsible for Rett syndrome. A MECP2 deficiency has been associated to catecholaminergic...

Benjamin D. (2020-11-10). "A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance". Journal of Neurodevelopmental...

presentation. These include: Coffin–Lowry syndrome DDX3X syndrome MASA syndrome MECP2 duplication syndrome Mental retardation and microcephaly with pontine and...

PMID 18254377. Meehan RR, Lewis JD, Bird AP (October 1992). "Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA". Nucleic...

research has focused on CpG islands and their associated binding-factor MeCP2. He led the team which first identified CpG islands—originally named "HpaII...

RT, He L, Kee SE, Wang W, Yu D, et al. (August 2016). "Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain...