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In enzymology, a macrolide 2'-kinase (EC 2.7.1.136) is an enzyme that catalyzes the chemical reaction ATP + oleandomycin ⇌ {\displaystyle \rightleftharpoons...

Macrolides are a class of mostly natural products with a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine...

1-kinase EC 2.7.1.135: Now EC 2.7.11.26, tau-protein kinase EC 2.7.1.136: macrolide 2′-kinase EC 2.7.1.137: phosphatidylinositol 3-kinase EC 2.7.1.138:...

a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases. mTOR...

also known as Rapa Nui, from where its name is derived. Rapamycin is a macrolide, produced by the microorganism Streptomyces hygroscopicus and showed antifungal...

as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant...

Bryostatins are a group of macrolide lactones from (bacterial symbionts of) the marine organism Bugula neritina that were first collected and provided...

mutations. It is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor. The most common side effects include diarrhea, rash, musculoskeletal...

Aigialomycin D is a macrolide antibiotic which is produced by the fungi Aigialus parvus. Aigialomycin D is a resorcylic acid lactone and has the molecular...

adverse reaction to medication, or emotional stress. Antibiotics: In the macrolide family of antibiotics, azithromycin, telithromycin (which is no longer...

Envarsus XR) is a product of the bacterium Streptomyces tsukubensis. It is a macrolide lactone and acts by inhibiting calcineurin. The drug is used primarily...

disease. One study showed that monocyte chemotactic protein-1 (chemokine CCL-2) and neutrophil gelatinase associated lipocalin (NGAL) were higher in patients...

can be isolated from the tunicate Ecteinascidia turbinata with a yield of 2 g per ton. This would require thousands of tons of tunicate to be grown and...

P-glycoprotein and CYP3A4, such as erythromycin or clarithromycin. People taking macrolide antibiotics, ketoconazole, or cyclosporine, or those who have liver or...

families that C. acnes are most likely to acquire resistance to are the macrolides (e.g., erythromycin and azithromycin), lincosamides (e.g., clindamycin)...

brevis". Limnology and Oceanography. 53 (2): 531–541. Bibcode:2008LimOc..53..531P. doi:10.4319/lo.2008.53.2.0531. Shimizu, Y (1996). "Microbial metabolites:...

began working on understanding the molecular mechanism of rapamycin; a macrolide antibiotic discovered in the soil of Easter Island that has potent antifungal...

Malpartida F, Zotchev SB (2008). "Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents". Current...

Pfizer acquired the worldwide rights to Zithromax (azithromycin), a macrolide antibiotic that is recommended by the Infectious Disease Society of America...

The bafilomycins are a family of macrolide antibiotics produced from a variety of Streptomycetes. Their chemical structure is defined by a 16-membered...