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Crossover junction endonuclease MUS81 is an enzyme that in humans is encoded by the MUS81 gene. In mammalian somatic cells, MUS81 and another structure specific...

remaining are the result of the class II pathway, which is regulated by MUS81 endonuclease and FANCM translocase. There are interconnections between these...

shares redundancy with the EME1/MUS81 protein complex for DNA damage repair in mammalian cells. GEN1 and EME1/MUS81, in mice, have redundant functions...

the EME1 gene. It forms a complex with MUS81 which resolves Holliday junctions. In mammalian cells the EME1/MUS81 protein complex is redundant for DNA damage...

protozoan Tetrahymena thermophila, MUS81 appears to be part of an essential, if not the predominant crossover pathway. The MUS81 pathway also appears to be the...

It must then be processed by fork-specific proteins. The most notable is MUS81. Deletions of which causes UV or methylation damage sensitivity in yeast...

for completion of meiosis. Meiosis in T. thermophila appears to employ a Mus81-dependent pathway that does not use a synaptonemal complex and is considered...

stage of crosslink repair involves production of double-strand breaks. MUS81/EME1 is a structure specific endonuclease involved in converting interstrand...

for completion of meiosis. Meiosis in T. thermophila appears to employ a Mus81-dependent pathway that does not use a synaptonemal complex and is considered...

to genome stability, genetic dependence on cellular nucleases GEN1 and MUS81, and loss of normal cell growth. Bloom-like phenotypes have been associated...

BY 4.0 license. Lukaszewicz A, Howard-Till RA, Loidl J (November 2013). "Mus81 nuclease and Sgs1 helicase are essential for meiotic recombination in a...

(BTR), SLX1-SLX4-MUS81-EME1-ERCC1-XPF (SMX) and GEN1. His laboratory discovered that the Holliday junction resolvase activities of MUS81 and GEN1 are regulated...

recombination occur. CHEK2 has been shown to interact with: BRCA1 GINS2 MDC1 MSH2 MUS81 PLK1 PLK3 GRCh38: Ensembl release 89: ENSG00000183765 – Ensembl, May 2017...

Q96DR8 10053 MUCL3 HGNC:21666 Q3MIW9 10054 MUL1 HGNC:25762 Q969V5 10055 MUS81 HGNC:29814 Q96NY9 10056 MUSK HGNC:7525 O15146 10057 MUSTN1 HGNC:22144 Q8IVN3...

enabled by a protein known as RAD52, which then recruits enzymes, including MUS81 and POLD3. These enzymes work to promote MiDAS, operating outside of ATR...

endonuclease activity of Mus81-Mms4 increases. This suggests inverted repeat sequences may enhance the activity of endonucleases like Mus81-Mms4 when bound to...

Kung J, Wang M, Lu HM, Paganetti H, et al. (May 2016). "Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton Radiation"...

nucleases comprising two subunits. Such nucleases include, for example, the MUS81-EME1 nuclease. The ERCC1–XPF complex is a structure-specific endonuclease...

nucleases comprising two subunits. Such nucleases include, for example, the MUS81-EME1 nuclease. The ERCC1–XPF complex is a structure-specific endonuclease...

bacteriophages (T7 endonuclease I), bacteria (RuvC), fungi (GEN1) and humans (hMus81-Eme1) have revealed that the enzymes function in dimers, and part of the...