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glutamate hypothesis of schizophrenia models the subset of pathologic mechanisms of schizophrenia linked to glutamatergic signaling. The hypothesis was...

dopamine hypothesis of schizophrenia or the dopamine hypothesis of psychosis is a model that attributes the positive symptoms of schizophrenia to a disturbed...

also be responsible for deficits in working memory. The glutamate hypothesis of schizophrenia links alterations between glutamatergic neurotransmission...

understood. A number of hypotheses including the dopamine hypothesis, and the glutamate hypothesis have been put forward in an attempt to explain the link...

further brain development, glutamate receptors broke down. This theory supports the glutamate hypothesis of schizophrenia. Another study in 2009 by Simon...

schizophrenia. They claim these results are consistent with the glutamate hypothesis of schizophrenia, which proposes that dysfunction in this neurotransmitter...

aging. Schizophrenia may also have to do with irregular NMDA receptor function (the glutamate hypothesis of schizophrenia). Increased levels of another...

onset of catatonia can be acute or subtle and symptoms can wax, wane, or change during episodes. It has historically been related to schizophrenia (catatonic...

wider range of symptoms that resemble schizophrenia in healthy volunteers, in what has led to the glutamate hypothesis of schizophrenia. Experiments...

The most commonly supported theories are the dopamine hypothesis and the glutamate hypothesis. Multiple genetic and environment factors have been associated...

varying levels of gliotransmission and calcium excitability. One theory, called the glutamate hypothesis of schizophrenia, suggests that glutamate deficiency...

dopamine activity and NMDArs, thus linking dopamine hypothesis of schizophrenia with the glutamate hypothesis of the disease. Kynurenic acid is reduced in individuals...

Evidence for the involvement of glutamate in schizophrenia includes analogous symptoms which are produced by glutamate NMDA receptor antagonists such...

supports the hypo-glutamatergic neurotransmission hypothesis in schizophrenia. The release of glutamate by system Xc- may lead to excitotoxicity, which...

Javitt D (January 2012). "From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment". Neuropsychopharmacology...

antipsychotic) to be discovered. It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to...

received regulatory approval (e.g. by the FDA of the US, the TGA of Australia, the MHRA of the UK) for schizophrenia, bipolar disorder, irritability in autism...

2018). "Beyond the dopamine hypothesis of schizophrenia to three neural networks of psychosis: dopamine, serotonin, and glutamate". CNS Spectrums. 23 (3):...

protein GAD67, an enzyme that catalyzes the formation of GABA from glutamate. Individuals with schizophrenia have shown a decrease in GAD67 levels and this deficit...

agonist action of mGluR2/3 agonists at D2 receptors were unsuccessful. Based on the glutamate hypothesis of schizophrenia, glutamate receptor agonists...