Search results

Gain-of-function research (GoF research or GoFR) is medical research that genetically alters an organism in a way that may enhance the biological functions...

Gain of function may refer to: Gain-of-function mutation Gain-of-function research This disambiguation page lists articles associated with the title Gain...

Several of Muller's morphs correspond to the gain of function, including hypermorph (increased gene expression) and neomorph (novel function). Dominant...

hypermorphic mutation causes an increase in normal gene function. Hypermorphic alleles are gain of function alleles. A hypermorph can result from an increase...

gain-of-function variation in TLR7 disrupts immune tolerance, potentially increasing the risk of autoimmune disorders. In May 2022, unregulated gain-of...

garlic. Mutations in the STAT1 molecule can be gain of function (GOF) or loss of function (LOF). Both of them can cause different phenotypes and symptoms...

the research as dangerous "gain of function" research, but others argued that it did not technically count as gain of function research because the modified...

continues to be a concern in the research of pathogens. The greatest concern is frequently associated with gain-of-function mutations, which confer novel or increased...

plays some role in the maintenance of chronic inflammatory pain. There are currently many known gain-of-function mutations in the human SCN11A gene that...

suggests SARS-CoV-2 was developed for gain-of-function research on coronaviruses. The exact meaning of "gain of function" is disputed among experts. According...

exclusive production of eumelanin, whereas Mc1r inhibition causes exclusive production of pheomelanin (5, 10). Thus, gain-of-function Mc1r mutations cause...

nearly a dozen gain-of-function mutations of NaV1.7 had been linked to IEM. The multi-decades search which identified gene SCN9A as the cause of inherited...

proliferation or inhibition of apoptosis. If, through mutation, normal genes promoting cellular growth are up-regulated (gain-of-function mutation), they predispose...

ubiquitin-ligase activity of Ectodermin, an Ecto RING-finger mutant (C97A/C100A) is inactive in gain-of-function. Gain-of-function of FAM increases the responses...

In research, GMOs are used to study gene function and expression through loss of function, gain of function, tracking and expression experiments. By knocking...

not endorsing every gain-of-function experiment, has said that "[t]here clearly are going to be instances where gain-of-function research is necessary...

inferred. Two of the most common types of manipulation experiments are loss-of-function and gain-of-function experiments. In a loss-of-function (also called...

Lee FS (January 2008). "A gain-of-function mutation in the HIF2A gene in familial erythrocytosis". The New England Journal of Medicine. 358 (2): 162–168...

Gronvall GK (August 2015). "The Reemergent 1977 H1N1 Strain and the Gain-of-Function Debate". mBio. 6 (4). doi:10.1128/mBio.01013-15. PMC 4542197. PMID 26286690...

repeat expansions in exon 1 of the androgen receptor (AR) gene, which results in both loss of AR function and toxic gain of function. In men, the disease slowly...