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- The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the...7 KB (858 words) - 17:05, 6 July 2024
- prior to first dose, taking first dose at night (so avoiding falls, etc) and starting on low doses and titrating upwards. First pass effect Graham RM...4 KB (428 words) - 06:47, 8 November 2023
- rapid absorption, avoidance of first-pass metabolism, sustained plasma concentrations, and a local endometrial effect, while advantages of intravaginal...175 KB (18,968 words) - 15:19, 3 July 2024
- high first-pass effect, which results in high levels of estradiol and consequent estrogenic effects in the liver and low potency due to first-pass hepatic...223 KB (26,808 words) - 08:46, 18 May 2024
- administration as well. In particular, the oral route is subject to a high first-pass effect, which results in high levels of testosterone in the liver and consequent...55 KB (5,576 words) - 23:18, 22 March 2024
- producing complete abortion in a period of 24 hours due to the liver's first-pass effect which reduces the bioavailability of the misoprostol. Vaginal and...51 KB (4,767 words) - 15:29, 17 July 2024
- fluid. ADME Partition coefficient Bioavailability Drug metabolism First pass effect Polar surface area IVIVC Mehta M (2016). Biopharmaceutics Classification...6 KB (617 words) - 10:32, 15 December 2023
- the gut. It has a total bioavailability of 10% due to an extensive first-pass effect, or up to 40% if taken after a fatty meal. Highest blood plasma levels...15 KB (1,415 words) - 13:41, 16 April 2024
- method of treatment, as vascular delivery suffers from a "pulmonary first pass effect" where intravenous injected cells are sequestered in the lungs. Further...43 KB (4,870 words) - 19:37, 6 July 2024
- tranquillisers Ethanol (alcohol) Diazoxide Drugs subject to a strong first-pass effect such as beta blockers may increase the bioavailability of hydralazine...16 KB (1,325 words) - 22:11, 12 August 2024
- administration(first pass effect is avoided and therefore no amount drug is lost). A drug must be lipophilic (lipid soluble) in order to pass through biological...48 KB (4,745 words) - 12:05, 14 August 2024
- the liver before reaching general circulation. This is known as the first pass effect. As a consequence, certain drugs can only be taken via certain routes...8 KB (1,006 words) - 15:02, 16 June 2024
- gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to...10 KB (1,210 words) - 12:41, 14 July 2024
- established. Idebenone is well absorbed from the gut but undergoes excessive first pass metabolism in the liver, so that less than 1% reach the circulation. This...15 KB (1,513 words) - 22:47, 26 February 2024
- Route of administration (section Desired target effect)the distal one-third of the rectum at least partially avoid the "first pass effect" through the liver, which allows for greater bio-availability of many...43 KB (4,411 words) - 22:36, 14 August 2024
- Dunning–Kruger effect is a cognitive bias in which people with limited competence in a particular domain overestimate their abilities. It was first described...46 KB (5,130 words) - 20:24, 8 August 2024
- mucosa bypass gastrointestinal enzymatic degradation and hepatic first-pass effect", prescribing buccal tablets is increasingly common among healthcare...21 KB (2,531 words) - 14:27, 14 February 2024
- first-pass effect. Less than 20% is eliminated by renal excretion. Ethylenediamine-derived antihistamines are the oldest of the five classes of first-generation...13 KB (1,053 words) - 15:25, 26 January 2024
- reaches the systemic circulation unchanged, due to a substantial first-pass effect. Bromocriptine reaches mean peak plasma levels after about 1–1.5 hours...44 KB (5,009 words) - 01:01, 9 August 2024
- The Butterfly Effect is a 2004 American science fiction thriller film written and directed by Eric Bress and J. Mackye Gruber. It stars Ashton Kutcher...22 KB (2,628 words) - 04:10, 13 August 2024
- relation between cause and effect; when they realized their own inability to bring matter out of nothingness, or to make it pass into nothingness again.
- Virginia Legislature. 1789- 1st Amendment to the Constitution The First Amendment, as passed by the House and Senate and later ratified by the States, reads:
- the frequency will be smaller, which is an effect that rapidly changes to a lower pitch as the train passes, going away from you. This works with light