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The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the...

prior to first dose, taking first dose at night (so avoiding falls, etc) and starting on low doses and titrating upwards. First pass effect Graham RM...

rapid absorption, avoidance of first-pass metabolism, sustained plasma concentrations, and a local endometrial effect, while advantages of intravaginal...

high first-pass effect, which results in high levels of estradiol and consequent estrogenic effects in the liver and low potency due to first-pass hepatic...

administration as well. In particular, the oral route is subject to a high first-pass effect, which results in high levels of testosterone in the liver and consequent...

producing complete abortion in a period of 24 hours due to the liver's first-pass effect which reduces the bioavailability of the misoprostol. Vaginal and...

fluid. ADME Partition coefficient Bioavailability Drug metabolism First pass effect Polar surface area IVIVC Mehta M (2016). Biopharmaceutics Classification...

the gut. It has a total bioavailability of 10% due to an extensive first-pass effect, or up to 40% if taken after a fatty meal. Highest blood plasma levels...

method of treatment, as vascular delivery suffers from a "pulmonary first pass effect" where intravenous injected cells are sequestered in the lungs. Further...

tranquillisers Ethanol (alcohol) Diazoxide Drugs subject to a strong first-pass effect such as beta blockers may increase the bioavailability of hydralazine...

administration(first pass effect is avoided and therefore no amount drug is lost). A drug must be lipophilic (lipid soluble) in order to pass through biological...

the liver before reaching general circulation. This is known as the first pass effect. As a consequence, certain drugs can only be taken via certain routes...

gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to...

established. Idebenone is well absorbed from the gut but undergoes excessive first pass metabolism in the liver, so that less than 1% reach the circulation. This...

the distal one-third of the rectum at least partially avoid the "first pass effect" through the liver, which allows for greater bio-availability of many...

Dunning–Kruger effect is a cognitive bias in which people with limited competence in a particular domain overestimate their abilities. It was first described...

mucosa bypass gastrointestinal enzymatic degradation and hepatic first-pass effect", prescribing buccal tablets is increasingly common among healthcare...

first-pass effect. Less than 20% is eliminated by renal excretion. Ethylenediamine-derived antihistamines are the oldest of the five classes of first-generation...

reaches the systemic circulation unchanged, due to a substantial first-pass effect. Bromocriptine reaches mean peak plasma levels after about 1–1.5 hours...

The Butterfly Effect is a 2004 American science fiction thriller film written and directed by Eric Bress and J. Mackye Gruber. It stars Ashton Kutcher...