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Farnesyltransferase (EC 2.5.1.58) is one of the three enzymes in the prenyltransferase group. Farnesyltransferase (FTase) adds a 15-carbon isoprenoid...

The farnesyltransferase inhibitors (FTIs) are a class of experimental cancer drugs that target protein farnesyltransferase with the downstream effect of...

methylation. Carboxyl methylation only occurs on prenylated proteins. Farnesyltransferase and geranylgeranyltransferase I are very similar proteins. They consist...

Farnesyl-diphosphate farnesyltransferase 1 is a protein that in humans is encoded by the FDFT1 gene. This gene encodes a membrane-associated enzyme located...

1126/science.1153018. PMC 2747771. PMID 18276850. Farnesyl-Diphosphate+Farnesyltransferase at the U.S. National Library of Medicine Medical Subject Headings...

triggers three sequential enzymatic modifications. First, protein farnesyltransferase catalyzes the addition of a farnesyl moiety to the cysteine. Second...

systematic name (2E,6E)-farnesyl-diphosphate:(2E,6E)-farnesyl-diphosphate farnesyltransferase (presqualene diphosphate forming). This enzyme catalyses the following...

name Zarnestra) is a farnesyltransferase inhibitor. Farnesyltransferase inhibitors block the activity of the farnesyltransferase enzyme by inhibiting...

midazolam and certain cholesterol-lowering medications. Lonafarnib, a farnesyltransferase inhibitor, is an oral medication that helps prevent the buildup of...

affinity modulator Sickle cell disease 2019 Lonafarnib (Zokinvy) Farnesyltransferase inhibitor Hutchinson-Gilford progeria syndrome 2020 2022 Dupilumab...

manipulate the regulation of the above-mentioned localization of Ras. Farnesyltransferase inhibitors have been developed to stop the farnesylation of Ras and...

Protein farnesyltransferase subunit beta is an enzyme that in humans is encoded by the FNTB gene. GRCm38: Ensembl release 89: ENSMUSG00000033373 – Ensembl...

an Ala, Met, Ser or Gln the protein will be farnesylated via the farnesyltransferase enzyme and if the X is a Leu then the protein will be geranylgeranylated...

are used infrequently in English. Sebti; Hamilton, eds. (2001). Farnesyltransferase inhibitors in cancer therapy. p. 126. ISBN 9780896036291. Retrieved...

treatment he devised for children affected by Progeria. He discussed how farnesyltransferase inhibitors (FTIs) affects H-Ras. After his presentation, members...

as drug R115777) inhibits the activation of RAS. This drug is a Farnesyltransferase inhibitor which inhibits the Ras kinase in a post translational modification...

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha is an enzyme that in humans is encoded by the FNTA gene. Prenyltransferases...

enzyme with systematic name farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase (4,4'-diapophytoene forming). This enzyme catalyses the following...

onto the C-terminal consensus sequence CAAL (somewhat similar to farnesyltransferase reactions), where C=cysteine, A=any aliphatic amino acid, and L=leucine...

prompted intense pharmaceutical industry pursuit of inhibitors of the farnesyltransferase enzyme that catalyzes this lipid modification on RAS and other proteins...