Draft:Andrzej Pohorille
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Andrzej (Andrew) Pohorille was born on May 14, 1949 in Szczecin, Poland. He died on January 6, 2024 at Stanford Hospital, Stanford, California, USA. Pohorille was a statistical and theoretical physicist, who studied the origin of life and made contributions to the significant expansion and maturation of astrobiology as a major field of scientific inquiry.[1]
Early life
He was the only child of Eugenia Gartenberg, a teacher, and Maksynilian Pohorille, a professor of economy at Main School of Planning and Statistics (SGPiS), now Warsaw School of Economics (SGH). His parents were the only members of their families to survive the Holocaust.
Personal life
He was married to Joanna Sokolowska-Pohorille and had no children.[citation needed]
Education and career
He received his Ph.D. in Theoretical Physics (with a specialization in Biophysics) from the University of Warsaw. The scientific advisor of his doctoral thesis was David Shugar and the reviewer was Wlodzimierz Kolos. He did his postdoctoral work with Prof. Bernard Pullman at the Institut de Biologie Physico-Chimique in Paris. Since 1992 he has been Professor of Chemistry and Pharmaceutical Chemistry at the University of California, San Francisco. In 1996, he joined the staff of the NASA Ames Research Center, where he directed the NASA Center for Computational Astrobiology.[2]
Research and contributions
His main interests have been focused on modeling the origins of life[3][4][5], computer simulations of biomolecular systems,[6][7][8] modeling genetic and metabolic networks,[9][10][11][12][13][14] and statistical mechanics of condensed phases.[15][16] He has also worked on t[17]he development of novel computational methods for parallel and distributed computing, on developing concepts and designing instruments for microbiology experiments on small satellites and in the lunar environment.[18] His most recent interests were in developing new ways to organize scientific information.[19]
He is internationally recognized in the origin of life community, and through his leadership has significantly strengthened NASA's programs in the broader field of astrobiology. He served as the computational lead for astrobiology projects on three successive NASA Astrobiology Institute (NAI) teams, and as the computational lead for two Internal Scientist Funding Model (ISFM) teams. The first was on the origin of life on Earth and the second was on the detection of life on other planets.[20]
He published scientific articles on a wide range of topics, ranging from the role of simple proteins in the Origin of Life[21][22], to molecular mechanisms of drugs, to in situ high throughput techniques for space biology[23]. His work includes many important publications like a very early molecular dynamics simulations on supercomputers[24] and a highly influential paper establishing best practices in free energy calculations.[25]
His other research interests were rather eclectic —he published papers in various in fields ranging from the structure of comets to the mechanism of anesthetic action and risky decision-making.
He was an author and coauthored of 147 peer-reviewed publications.[26]
Awards and Honors
- 1994 NASA Ames Space Science Division Recognition Award
- 2000 NASA Group Award for the Astrobiology Team
- 2002 NASA Exceptional Scientific Achievement Medal
- 2005 named Distinguished Lecturer at the Centre for Mathematical Modeling and the National Centre for Space Research in the U.K.
- 2008 James Clerk Maxwell Lecture, Edinburgh, U.K
- 2009 NASA Group Award for the Astrobiology Roadmap Team
- 2010 (together with Eric Darve) H. Julian Allen Award for the article Calculating Free Energies Using Average Force, published in Journal of Chemical Physics.[27]
- 2014 NASA Group Award
- 2023 NASA Exceptional Services Medal for "establishment of Astrobiology as a vibrant, rigorous and accessible scientific discipline".
SERVICE TO PROFESSIONAL PUBLICATIONS
| 2015 - 2020 | Referee of 29 papers: Astrobiology (3), Biophys. J. (5), Int. J. Astrobiol. (2), Current Opinion in Colloid and Interface Science (1), Int. J. of Astrobiology (3), J. Am. Chem. Soc. (1), J. Chem. Phys. (5), J. Chem. Theory Comp. (2), J. Phys. Chem. (2), Orig. Life. Evol. Biosphere (3), Proc. Natl. Acad. Sci. USA (1), Structure (1), JoVE (1), J. Chem. Inform. and Modeling (1), Life (1). |
| 2013 - 2013 | Reviewer of book proposal "Untangling Biodiversity" for World Scientific. |
| 2014 - 2014 | Reviewer of proposals for Research Corporation for Science Advancement and Templeton Foundation, and book proposal for CRC Press |
| 2015 - 2015 | Reviewer, proposals to NASA Science Innovation Fund and the National Science Foundation |
| 2016 - 2023 | Chief Editor, Astrobiology Section, journal Life |
| 2016 - 2020 | Swiss National Science Foundation, proposal reviewer |
| 2017 - 2017 | National Science Foundation, proposal reviewer |
INVITED PRESENTATIONS - INTERNATIONAL
| 2015 | Astrobiology Science Conference, Chicago, Illinois (2 oral presentations) |
| 2015 | The Emergence in Chemical Systems 4.0, Anchorage, Alaska (plenary speaker) |
| 2015 | Free-energy calculations. A mathematical perspective, Oaxaca, Mexico (invited speaker) |
| 2015 | Challenges in Molecular Biology, Biophysics and Biomedicine, Warsaw, Poland (invited speaker) |
| 2015 | COSPAR Symposium "Water in the Universe", Foz do Iguasu, Brazil (oral presentation) |
| 2016 | LUCA and Horizontal Gene Transfer, Milton Keynes, U.K. (keynote speaker) |
| 2017 | Early Earth and ExoEarths: origin and evolution of life, Warsaw, Poland (invited presentation and contributed oral presentation) |
| 2017 | XVIIIth International Conference on the Origin of Life,San Diego, CA (invited plenary panel speaker) |
| 2017 | Astrobiology 2017, Coyhaique, Chile (oral presentation) |
| 2018 | Multiscale modelling in electrophysiology: from atoms to organs, Lugano, Switzerland (invited presentation) |
| 2018 | Puzzles and Solutions in Astrobiology, Tokyo, Japan (invited presentation) |
| 2018 | EANA 2018, Berlin, Germany (oral presentation) |
INVITED PRESENTATIONS - USA
| 2015 | Workshop on the Potential for Finding Life in a Europa Plume, Moffett Field, California (oral presentation) |
| 2015 | Arizona State University, invited seminar |
| 2015 | Ion Channels Biophysics, Telluride, CO (invited presentation) |
| 2016 | Ions in Solution: Biology, Energy and Environment, Telluride, CO (invited presentation) |
| 2017 | Astrobiology Science Conference 2017 ((invited presentation and contributed oral presentation) |
| 2017 | Ion Channels Biophysics, Telluride, CO (invited presentation) |
| 2019 | Breakthrough Discuss Conference, Berkeley, CA (invited panelist) |
| 2019 | Astrobiology Science Conference 2019, Seattle, WA (co-organizer of two session, one oral presentation) |
GOVERNMENT AND OTHER PROFESSIONAL SERVICE
| 2007 - 2017 | NASA Origin of Life Focus Group | Chair |
| 2010 - 2010 | Astrobiology Science Conference | Judge of student posters |
| 2013 - 2013 | Horizontal Gene Transfer and the Last Universal Common Ancestor Conference, London | Member, International Organizing Committee |
| 2013 - 2013 | Emergence in Biological Systems. Anchorage | Member, International Organizing Committee |
| 2013 - 2023 | Encyclopedia of Astrobiology (Springer) | Field editor for chemistry |
| 2014 - 2014 | site visit review of the NASA/NSF Center for Chemical Evolution at Georgia Tech. | reviewer |
| 2015 - 2015 | Emergence in Biological Systems. Anchorage | Member, International Organizing Committee |
| 2015 - 2015 | The National Academies' Committee on Biological and Physical Sciences in Space | Member, Panel on Achieving Science Goals with CubeSats |
| 2016 - 2017 | NASA Advisory Board for GeneLab | member |
| 2017 - 2023 | NASA Center for Life Detection | Co-lead |
| 2017 - 2023 | Build-A-Cell: An Open Community Considering & Advancing the Construction of Synthetic Cells | member |
UNIVERSITY AND PUBLIC SERVICE
His public service activities were primarily concentrated around promoting the emerging interdisciplinary field of astrobiology. In particular, his efforts were concentrated on promoting modern, enlightened views on the origins and early evolution of life through public lectures, dialogue with open-minded religious communities and making his expertise available to both students and the public. He participated in the creation of both the first and the second Astrobiology Roadmap, had lectures on the origins of life for teachers in their continuing education program and taped Internet lectures on this subject. He advised the National Research Council Committee on the Origins of Life, chaired the Origin of Life Focus group, which consisted of nearly 150 researchers in the field. He organized workshops and conference sessions in the area of astrobiology and participated in a large "Encyclopedia of Astrobiology" project as a field editor for the origin of life. Most recently, He co-led NASA Center for Life Detection charged with developing scientific basis for the forthcoming missions and observational efforts to detect possible signs of life in the solar system and beyond.
COMMUNITY AND PUBLIC SERVICE
| 1999 - 2007 | External Advisory Board member (and chair in 2001-2002) of the NSF Center of Excellence in Historically Black Universities: Computational Center for Molecular Structure and Interactions located in Jackson State University |
| 1999 - 2023 | Nationally and internationally public lectures in astrobiology and the origins of life |
| 1999 - 2006 | External Advisory Board member (and chair in 2001-2002) of the NSF Center of Excellence in Historically Black Universities: Computational Center for Molecular Structure and Interactions located in Jackson State University |
| 2000 - 2010 | Participant in the "Ask an Astrobiologist" Program (see HYPERLINK "http://nai.arc.nasa.gov/astrobio/" http://nai.arc.nasa.gov/astrobio/ |
| 2006 - 2006 | Lecturer, the AAAS Program on the Dialogue on Science, Ethics and Religion (see HYPERLINK "http://www.aaas.org/news/releases/2006/0203origins.shtml" http://www.aaas.org/news/releases/2006/0203origins.shtml) |
| 2006 - 2006 | Organized the first program to train scientists and students in American Indian Colleges in computational biology |
| 2006 - 2006 | Organized the first program to train scientists and students in American Indian Colleges in computational biology |
| 2006 - 2006 | In front of the audience of 300 people debated Prof. David Deamer from UCSC on deterministic origins of life at Wonderfest 06 (the Bay Area Festival of Science). |
| 2010 - 2010 | Invited talk for San Francisco Amateur Astronomers "Origin of Life in the Universe - Chance or Necessity". |
CONTRIBUTIONS TO DIVERSITY
1999-2007 - External Advisory Board member (and chair in 2001-2002) of the NSF Center of Excellence in Historically Black Universities: Computational Center for Molecular Structure and Interactions located in Jackson State University.
2020-2023 – Member, Diversity and Inclusion Team, NASA Ames Research Center.
References
- ^ Cowing, Keith (2024-02-09). "In Memoriam: Andrzej Pohorille". Astrobiology. Retrieved 2024-08-07.
- ^ "Andrew Pohorille - NASA". Retrieved 2024-08-07.
- ^ Pohorille, Andrew (2012). "Processes that Drove the Transition from Chemistry to Biology: Concepts and Evidence". Origins of Life and Evolution of Biospheres. 42 (5): 429–432. Bibcode:2012OLEB...42..429P. doi:10.1007/s11084-012-9304-3. ISSN 0169-6149. PMID 23080008.
- ^ Pohorille, Andrew; Pratt, L. R. (2012). "Is Water the Universal Solvent for Life?". Origins of Life and Evolution of Biospheres. 42 (5): 405–409. Bibcode:2012OLEB...42..405P. doi:10.1007/s11084-012-9301-6. ISSN 0169-6149.
- ^ "NASA Astrobiology". astrobiology.nasa.gov. Retrieved 2024-08-07.
- ^ Wilson, Michael A.; Wei, Chenyu; Bjelkmar, Pär; Wallace, B.A.; Pohorille, Andrew (2011). "Molecular Dynamics Simulation of the Antiamoebin Ion Channel: Linking Structure and Conductance". Biophysical Journal. 100 (10): 2394–2402. Bibcode:2011BpJ...100.2394W. doi:10.1016/j.bpj.2011.03.054. PMC 3093558. PMID 21575573.
- ^ Wilson, Michael A.; Pohorille, Andrew (2021-05-06). "Electrophysiological Properties from Computations at a Single Voltage: Testing Theory with Stochastic Simulations". Entropy. 23 (5): 571. Bibcode:2021Entrp..23..571W. doi:10.3390/e23050571. ISSN 1099-4300. PMC 8148522. PMID 34066581.
- ^ Wilson, Michael; Pohorille, Andrew (2022). "Computer modeling of the Structure and Conductance of LS3, a Synthetic Ion Channel". The Journal of Physical Chemistry B. 126 (44): 8995–8999. doi:10.1021/acs.jpcb.2c05965. PMID 36306164. Retrieved 2024-08-18 – via ACS Publications.
- ^ Wei, Chenyu; Pohorille, Andrew (2009). "Permeation of Membranes by Ribose and Its Diastereomers". Journal of the American Chemical Society. 131 (29): 10237–10245. Bibcode:2009JAChS.13110237W. doi:10.1021/ja902531k. PMID 19621967 – via ResearChgate.
- ^ Pohorille, Andrew; Deamer, David (2009). "Self-assembly and function of primitive cell membranes". Research in Microbiology. 160 (7): 449–456. Bibcode:2009ResMb.160..449P. doi:10.1016/j.resmic.2009.06.004. PMID 19580865.
- ^ Wei, Chenyu; Pohorille, Andrew (2013). "Permeation of Aldopentoses and Nucleosides Through Fatty Acid and Phospholipid Membranes: Implications to the Origins of Life". Astrobiology. 13 (2): 177–188. Bibcode:2013AsBio..13..177W. doi:10.1089/ast.2012.0901. ISSN 1531-1074. PMID 23397957.
- ^ Wei, Chenyu; Pohorille, Andrew (2011-04-07). "Permeation of Nucleosides through Lipid Bilayers". The Journal of Physical Chemistry B. 115 (13): 3681–3688. Bibcode:2011JPCB..115.3681W. doi:10.1021/jp112104r. ISSN 1520-6106. PMID 21405137.
- ^ Wei, Chenyu; Pohorille, Andrew (2021). "Fast bilayer-micelle fusion mediated by hydrophobic dipeptides". Biophysical Journal. 120 (11): 2330–2342. Bibcode:2021BpJ...120.2330W. doi:10.1016/j.bpj.2021.04.012. ISSN 0006-3495. PMC 8390801. PMID 33887225.
- ^ Wei, Chenyu; Pohorille, Andrew (2023). "Multi-oligomeric states of alamethicin ion channel: Assemblies and conductance". Biophysical Journal. 122 (12): 2531–2543. Bibcode:2023BpJ...122.2531W. doi:10.1016/j.bpj.2023.05.006. PMC 10323028. PMID 37161094.
- ^ Darve, Eric; Pohorille, Andrew (2001-11-22). "Calculating free energies using average force". The Journal of Chemical Physics. 115 (20): 9169–9183. Bibcode:2001JChPh.115.9169D. doi:10.1063/1.1410978. hdl:2060/20010090348. ISSN 0021-9606.
- ^ Darve, Eric; Rodríguez-Gómez, David; Pohorille, Andrew (2008-04-11). "Adaptive biasing force method for scalar and vector free energy calculations". The Journal of Chemical Physics. 128 (14). Bibcode:2008JChPh.128n4120D. doi:10.1063/1.2829861. ISSN 0021-9606. PMID 18412436.
- ^ Pohorille, Andrew; Wilson, Michael A.; Shannon, Gareth (2017). "Flexible Proteins at the Origin of Life". Life. 7 (2): 23. Bibcode:2017Life....7...23P. doi:10.3390/life7020023. ISSN 2075-1729. PMC 5492145. PMID 28587235.
- ^ Peyvan, Kianoosh; Karouia, Fathi; Cooper, John J.; Chamberlain, Jeff; Suciu, Dominic; Slota, Michael; Pohorille, Andrew (August 2019). "Gene Expression Measurement Module (GEMM) for space application: Design and validation". Life Sciences in Space Research. 22: 55–67. Bibcode:2019LSSR...22...55P. doi:10.1016/j.lssr.2019.07.004. PMID 31421849.
- ^ Hoehler, Tori; Brinckerhoff, Will; Davila, Alfonso; Marais, David Des; Getty, Stephanie; Glavin, Danny; Pohorille, Andrew; Quinn, Richard; Bebout, Lee; Broddrick, Jared; Dateo, Christopher; Eigenbrode, Jennifer; Everroad, Craig; Karouia, Fathi; Lafuente, Barbara (2021-03-18). "Groundwork for Life Detection". Bulletin of the AAS. 53 (4): 202. Bibcode:2021BAAS...53d.202H. doi:10.3847/25c2cfeb.bd9172f9.
- ^ Pohorille, Andrew; Sokolowska, Joanna (2020-10-01). "Evaluating Biosignatures for Life Detection". Astrobiology. 20 (10): 1236–1250. Bibcode:2020AsBio..20.1236P. doi:10.1089/ast.2019.2151. ISSN 1531-1074. PMC 7591378. PMID 32808814.
- ^ Pohorille, Andrew; Deamer, David (September 2009). "Self-assembly and function of primitive cell membranes". Research in Microbiology. 160 (7): 449–456. Bibcode:2009ResMb.160..449P. doi:10.1016/j.resmic.2009.06.004. PMID 19580865.
- ^ Rasmussen, Steen; Bedau, Mark A.; Chen, Liaohai; Deamer, David; Krakauer, David C.; Packard, Norman H.; Stadler, Peter F., eds. (2008-11-07). Protocells: Bridging Nonliving and Living Matter. The MIT Press. doi:10.7551/mitpress/9780262182683.001.0001. ISBN 978-0-262-28209-3.
- ^ Karouia, Fathi; Peyvan, Kianoosh; Pohorille, Andrew (November 2017). "Toward biotechnology in space: High-throughput instruments for in situ biological research beyond Earth". Biotechnology Advances. 35 (7): 905–932. doi:10.1016/j.biotechadv.2017.04.003. PMID 28433608.
- ^ Pohorille, Andrew; Ross, Wilson S.; Tinoco, Ignacio (September 1990). "Dna Dynamics in Aqueous Solution: Opening the Double Helix". The International Journal of Supercomputing Applications. 4 (3): 81–96. doi:10.1177/109434209000400309. ISSN 0890-2720. PMID 11538365.
- ^ Pohorille, Andrew; Jarzynski, Christopher; Chipot, Christophe (2010-08-19). "Good Practices in Free-Energy Calculations". The Journal of Physical Chemistry B. 114 (32): 10235–10253. Bibcode:2010JPCB..11410235P. doi:10.1021/jp102971x. hdl:2060/20140000578. ISSN 1520-6106. PMID 20701361.
- ^ "Andrew Pohorille: Chemistry H-index & Awards". https://Research.com>Chemistry.
- ^ "File:HJA 2010 1.jpg - Wikipedia". commons.wikimedia.org. 2010-10-14. Retrieved 2024-08-07.
