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Bcl-xL and Bcl-w, known as ABT-737. This compound is part of a group of BH3 mimetic small molecule inhibitors (SMI) that target these Bcl-2 family proteins...

Additionally, this drug may cause fertility problems in males. Venetoclax is a BH3-mimetic. Venetoclax blocks the anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein...

"Alterations in the Noxa/Mcl-1 axis determine of small cell to the BH3 mimetic ABT-737". Molecular Cancer Therapeutics. 8 (4): 883–92. doi:10.1158/1535-7163...

Vandenberg, Lin Chen, Peter E. Czabotar, Simon N. Willis et al. "The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis...

mitochondrial membrane. Drugs that activate BAX, such as ABT-737, a BH3 mimetic, hold promise as anticancer treatments by inducing apoptosis in cancer...

Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737". Mol Cancer Ther. 8 (4): 883–92. doi:10.1158/1535-7163.MCT-08-1118...

a stapled BH3 helix was identified which specifically activates the mitochondrial apoptotic pathway by antagonizing the sequestration of BH3-only proteins...

activity. Preclinical studies involving these inhibitors, also described as BH3 mimetics, have produced promising results. Irradiation therapy is dose-limited...

"Inhibition of MARCH5 ubiquitin ligase abrogates MCL1-dependent resistance to BH3 mimetics via NOXA". Oncotarget. 7 (13): 15986–6002. doi:10.18632/oncotarget.7558...

increase proliferation and antitumor activity alone and in combination with BH3 mimetics. "Building up its I/O ops, CRISPR Therapeutics allies with Marcela Maus...

and members are characterized by the Bcl-2 homologous domains BH1, BH2, BH3, and BH4. The combinations of the domains in the proteins determine its role...

make up a cell. Cory's lab has developed Bcl2-blocking agents called BH3 mimetics, which, when paired with low-dose chemotherapy, have had positive results...

Boranophosphates are salts with an anion consisting of borane (BH3) and phosphite groups. One of the simplest examples is [(CH3O)2OPBH3]−, prepared by...

using stapled peptides including cancer targets such as p53, MCL-1 BH3, PUMA BH3, Notch, and beta-Catenin, as well as other therapeutic targets ranging...

PMID 19228717. Paoluzzi L, Gonen M, Bhagat G, et al. (October 2008). "The BH3-only mimetic ABT-737 synergizes the antineoplastic activity of proteasome inhibitors...

understood, but in general, Bax or Bak are activated by the activation of BH3-only proteins, part of the Bcl-2 family. Caspases play the central role in...