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1 (BACE1), membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene...

opposite strand to BACE1 and is upregulated in patients with Alzheimer's disease. BACE1-AS regulates the expression of BACE1 by increasing BACE1 mRNA stability...

APP-cleaving enzyme 1 gene (BACE1). Dr. Zetterberg and his team used a sensitive and specific BACE1 assay to assess CSF BACE1 activity in AD. It was found...

antisense RNA, BACE1-AS is transcribed from the opposite strand to BACE1 and is upregulated in patients with Alzheimer's disease. BACE1-AS regulates the...

neuroinflammation of rats with Alzheimer's disease via regulating the SP1/BACE1/NLRP3/Caspase-1 signaling pathway". Bosnian Journal of Basic Medical Sciences...

Bolon B, Damore MA, Fitzpatrick D, Liu H, Zhang J, et al. (October 2003). "BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression...

effectively inhibited BACE1 enzymatic function, experienced problems transferring adequate, efficient levels of the antibody within the brain. BACE1 is the enzyme...

expression of BACE1 gene. However, BACE1 expression can be activated by phosphorylation of eIF2a, which reverses the inhibitory effect exerted by BACE1 5′ UTR...

variant of Alzheimer's amyloid precursor protein. BACE2 is a close homolog of BACE1. Cerebral deposition of amyloid beta peptide is an early and critical feature...

acidic conditions. BACE1, BACE2 Cathepsin D Cathepsin E Chymosin (or "rennin") Napsin-A Nepenthesin Pepsin Presenilin Renin BACE1; BACE2; CTSD; CTSE;...

treated with H2O2, one particular gene was examined, BACE1. The methylation level of the BACE1 CpG island was reduced (an epigenetic alteration) and...

treated with H2O2, one particular gene was examined, BACE1. The methylation level of the BACE1 CpG island was reduced (an epigenetic alteration) and...

Especially, the ratio of CSF neurogranin trunc P75 and the beta-secretase BACE1 is suggested as a potential marker for cognitive deterioration in the progress...

Ghoshal N (Oct 2010). "Rationalizing fragment based drug discovery for BACE1: insights from FB-QSAR, FB-QSSR, multi objective (MO-QSPR) and MIF studies"...

(January 2019). "Temporal Effects of Neuron-specific beta-secretase 1 (BACE1) Knock-in on the Mouse Brain Metabolome: Implications for Alzheimer's Disease"...

have shown that specifically targeting Amyloid beta-producing genes (e.g. BACE1 and APP) by RNAi can significantly reduced the amount of Aβ peptide which...

brain inflammation. Furthermore, nucleic acids corresponding to APP, Aβ42, BACE1, and tau protein biomarkers were found to be associated with different neurodegenerative...

"Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity". Bioorganic & Medicinal Chemistry Letters. 20 (11):...

Q14032 1396 BABAM1 HGNC:25008 Q9NWV8 1397 BABAM2 HGNC:1106 Q9NXR7 1398 BACE1 HGNC:933 P56817 1399 BACE2 HGNC:934 Q9Y5Z0 1400 BACH1 HGNC:935 O14867 1401...

treatment of Alzheimer's disease. It is an inhibitor of beta-secretase 1 (BACE1), which, after initial promise proved disappointing. In April 2012 phase...