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Mammalian protein found in Homo sapiens
Glycerol-3-phosphate acyltransferase 3 (GPAT-3) is an enzyme that in humans is encoded by the AGPAT9 gene .[ 5] [ 6] [ 7] [ 8]
1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9),lysophosphatidic acid acyltransferase theta (LPAAT-theta), orlung cancer metastasis-associated protein 1 .
Function
Glycerol-3-phosphate (G3P) acyltransferases (GPAT; EC 2.3.1.15), such as GPAM and GPAT3 (this enzyme), catalyze the initial step of de novo triacylglycerol (TAG) synthesis by converting glycerol-3-phosphate (G3P) to lysophosphatidic acid (LPA).[ 6]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000138678 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029314 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Clark HF, Gurney AL, Abaya E, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . ^ a b Cao J, Li JL, Li D, Tobin JF, Gimeno RE (December 2006). "Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis" . Proc. Natl. Acad. Sci. U.S.A . 103 (52): 19695–700. Bibcode :2006PNAS..10319695C . doi :10.1073/pnas.0609140103 PMC 1702318 PMID 17170135 . ^ Tang W, Yuan J, Chen X, Gu X, Luo K, Li J, Wan B, Wang Y, Yu L (September 2006). "Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway" . J. Biochem. Mol. Biol . 39 (5): 626–35. doi :10.5483/BMBRep.2006.39.5.626 PMID 17002884 . ^ "Entrez Gene: AGPAT9: 1-acylglycerol-3-phosphate O-acyltransferase 9" .
External links
Further reading
Tang W, Yuan J, Chen X, et al. (2006). "Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway" . J. Biochem. Mol. Biol . 39 (5): 626–35. doi :10.5483/BMBRep.2006.39.5.626 PMID 17002884 . Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas" . Oncogene . 23 (35): 5901–11. doi :10.1038/sj.onc.1207782 PMID 15221005 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
