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Protein-coding gene in the species Homo sapiens
Three prime repair exonuclease 2 is an enzyme that in humans is encoded by the TREX2 gene .[ 5] [ 6]
This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication , repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III , which does not have intrinsic exonuclease activity.[ 6]
Mutations in this gene may lead to Aicardi-Goutieres syndrome
References
Further reading
Shevelev IV, Hübscher U (2002). "The 3' 5' exonucleases". Nat. Rev. Mol. Cell Biol . 3 (5): 364–76. doi :10.1038/nrm804 . PMID 11988770 . S2CID 31605786 .
Esposito T, Ciccodicola A, Flagiello L, et al. (1997). "Expressed STSs and transcription of human Xq28". Gene . 187 (2): 185–91. doi :10.1016/S0378-1119(96)00772-X . PMID 9099879 .
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 . PMID 11076863 .
Li T, Duan W, Yang H, et al. (2001). "Identification of two proteins, S14 and UIP1, that interact with UCH37". FEBS Lett . 488 (3): 201–5. Bibcode :2001FEBSL.488..201L . doi :10.1016/S0014-5793(00)02436-4 . hdl :10536/DRO/DU:30009147 . PMID 11163772 . S2CID 40717095 .
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–92. doi :10.1093/embo-reports/kvd058 . PMC 1083732 . PMID 11256614 .
Mazur DJ, Perrino FW (2001). "Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes" . J. Biol. Chem . 276 (18): 14718–27. doi :10.1074/jbc.M010051200 . PMID 11278605 .
Mazur DJ, Perrino FW (2001). "Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins" . J. Biol. Chem . 276 (20): 17022–9. doi :10.1074/jbc.M100623200 . PMID 11279105 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Shevelev IV, Beliakova NV, Kravetskaia TP, Krutiakov VM (2003). "[The correcting role of autonomous 3'-->5' exonucleases in mammalian multienzyme DNA polymerase complexes]". Mol. Biol. (Mosk.) . 36 (6): 1055–61. PMID 12500544 .
Shevelev IV, Ramadan K, Hübscher U (2004). "The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy" . ScientificWorldJournal . 2 : 275–81. doi :10.1100/tsw.2002.99 . PMC 6009725 . PMID 12806015 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline" . Genome Res . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 . PMID 15489336 .
Perrino FW, Krol A, Harvey S, et al. (2005). "Sequence variants in the 3'-->5' deoxyribonuclease TREX2: identification in a genetic screen and effects on catalysis by the recombinant proteins". Adv. Enzyme Regul . 44 : 37–49. doi :10.1016/j.advenzreg.2003.11.010 . PMID 15581481 .
Perrino FW, Harvey S, McMillin S, Hollis T (2005). "The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis" . J. Biol. Chem . 280 (15): 15212–8. doi :10.1074/jbc.M500108200 . PMID 15661738 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8. doi :10.1093/nar/gkj139 . PMC 1347501 . PMID 16381901 .
Hahn Y, Lee B (2007). "Human-specific nonsense mutations identified by genome sequence comparisons" . Hum. Genet . 119 (1–2): 169–78. doi :10.1007/s00439-005-0125-6 . PMID 16395595 . S2CID 21059468 .
Chen MJ, Ma SM, Dumitrache LC, Hasty P (2007). "Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2" . Nucleic Acids Res . 35 (8): 2682–94. doi :10.1093/nar/gkm151 . PMC 1885668 . PMID 17426129 .
Parra D, Manils J, Castellana B, Viña-Vilaseca A, Morán-Salvador E, Vázquez-Villoldo N, Tarancón G, Borràs M, Sancho S, Benito C, Ortega S, and Soler C (2009). "Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout Mice" . Cancer Research . 69 (16): 6676–84. doi :10.1158/0008-5472.CAN-09-1208 . PMID 19654293 .
External links
Overview of all the structural information available in the PDB for UniProt : Q9BQ50 (Human Three prime repair exonuclease 2) at the PDBe-KB .
Overview of all the structural information available in the PDB for UniProt : Q9R1A9 (Mouse Three prime repair exonuclease 2) at the PDBe-KB .