Arthur Weston (scientist): Difference between revisions

Add links
Source: Wikipedia, the free encyclopedia.
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
m EchidnaLives moved page Draft:Arthur Weston (scientist) to Arthur Weston (scientist): Publishing accepted Articles for creation submission (AFCH 0.9.1)
Cleaning up accepted Articles for creation submission (AFCH 0.9.1)
Line 1: Line 1:
{{Short description|British Pharmacologist}}
{{Short description|British Pharmacologist}}
{{Draft topics|biography|northern-europe|stem}}
{{AfC topic|blp}}
{{AfC submission|||ts=20221202011115|u=Gavin Mills|ns=118}}
{{AFC submission|d|reason|Weston is a well-known professor but everything must have a source. Please add more inline references - see the referencing help at [[Help:Introduction|the Wikipedia tutorial]]. Material about his personal life must be available in published references to be used.|u=Gavin Mills|ns=118|decliner=StarryGrandma|declinets=20221019234710|ts=20221019153903}} <!-- Do not remove this line! -->




{{Infobox scientist
{{Infobox scientist
Line 38: Line 32:


== Career and research ==
== Career and research ==
Weston was made Lecturer in Pharmacology at Manchester in 1970, Senior Lecturer in 1979, Reader in 1987 and Professor in 1989<ref>{{Cite web |title=Weston, Prof. Arthur Henry, (born 31 May 1944), Leech Professor of Pharmacology, University of Manchester, 1990–2011, now Emeritus |url=https://www.ukwhoswho.com/view/10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-43701 |access-date=2022-12-02 |website=WHO'S WHO & WHO WAS WHO |language=en |doi=10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-43701?rskey=fgx3np&result=1}}</ref>. In 1974, he was awarded an Alexander von [[Humboldt fellowship|Humboldt Fellowship]] to study in the Department of Physiology in the [[University of Marburg]] and a senior Humboldt Fellowship to study in the Department of Physiology in the [[Heidelberg University|University of Heidelberg]] in 1985. During 1987, he was a Royal Society-funded visiting Professor in the Department of Pharmacology, [[Kyushu University|University of Kyushu]], Japan. In 2011, Weston became a Visiting Fellow at [[Magdalen College, Oxford]]. At a national level, he was Honorary Treasurer, a Director and Trustee of the [[British Pharmacological Society]] (BPS) for the 8 years from 1999-2008.<ref>{{Cite web |title=Weston, Prof. Arthur Henry, (born 31 May 1944), Leech Professor of Pharmacology, University of Manchester, 1990–2011, now Emeritus |url=https://www.ukwhoswho.com/view/10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-43701 |access-date=2022-12-02 |website=WHO'S WHO & WHO WAS WHO |language=en |doi=10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-43701?rskey=fgx3np&result=1}}</ref>
Weston was made Lecturer in Pharmacology at Manchester in 1970, Senior Lecturer in 1979, Reader in 1987 and Professor in 1989<ref>{{Cite web |title=Weston, Prof. Arthur Henry, (born 31 May 1944), Leech Professor of Pharmacology, University of Manchester, 1990–2011, now Emeritus |url=https://www.ukwhoswho.com/view/10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-43701 |access-date=2022-12-02 |website=WHO'S WHO & WHO WAS WHO |language=en |doi=10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-43701?rskey=fgx3np&result=1}}</ref>. In 1974, he was awarded an Alexander von [[Humboldt fellowship|Humboldt Fellowship]] to study in the Department of Physiology in the [[University of Marburg]] and a senior Humboldt Fellowship to study in the Department of Physiology in the [[Heidelberg University|University of Heidelberg]] in 1985. During 1987, he was a Royal Society-funded visiting Professor in the Department of Pharmacology, [[Kyushu University|University of Kyushu]], Japan. In 2011, Weston became a Visiting Fellow at [[Magdalen College, Oxford]]. At a national level, he was Honorary Treasurer, a Director and Trustee of the [[British Pharmacological Society]] (BPS) for the 8 years from 1999-2008.<ref>{{Cite web |title=Weston, Prof. Arthur Henry, (born 31 May 1944), Leech Professor of Pharmacology, University of Manchester, 1990–2011, now Emeritus |url=https://www.ukwhoswho.com/view/10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-43701 |access-date=2022-12-02 |website=WHO'S WHO & WHO WAS WHO |language=en |doi=10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-43701?rskey=fgx3np&result=1}}</ref>


Weston's research focuses on the physiology and pharmacology of ion channels in blood vessels and on the development of drugs to treat vascular disease associated with hypertension, diabetes and obesity. During the 1980s he discovered a new class of agent which he designated the "[[potassium channel opener]]"<ref>{{Cite journal |last=Duty |first=Susan |last2=Weston |first2=Arthur H. |date=1990-12-01 |title=Potassium Channel Openers |url=https://doi.org/10.2165/00003495-199040060-00002 |journal=Drugs |language=en |volume=40 |issue=6 |pages=785–791 |doi=10.2165/00003495-199040060-00002 |issn=1179-1950}}</ref> and this has formed the basis of many on-going research programmes within the pharmaceutical industry. These studies led to the further discovery that blood vessels produce a relaxing factor that he termed "endothelium-derived hyperpolarizing factor" (EDHF)<ref>{{Cite journal |last=Busse |first=Rudi |last2=Edwards |first2=Gillian |last3=Félétou |first3=Michel |last4=Fleming |first4=Ingrid |last5=Vanhoutte |first5=Paul M. |last6=Weston |first6=Arthur H. |date=2002-08-01 |title=EDHF: bringing the concepts together |url=https://www.cell.com/trends/pharmacological-sciences/abstract/S0165-6147(02)02050-3 |journal=Trends in Pharmacological Sciences |language=English |volume=23 |issue=8 |pages=374–380 |doi=10.1016/S0165-6147(02)02050-3 |issn=0165-6147 |pmid=12377579}}</ref>. His most recent discoveries in Manchester concern the existence and role of a special calcium-sensing receptor in the endothelium of blood vessels<ref>{{Cite journal |last=Weston |first=A. H. |last2=Geraghty |first2=A. |last3=Egner |first3=I. |last4=Edwards |first4=G. |date=September 2011 |title=The vascular extracellular calcium-sensing receptor: an update: Ca2+-sensing in the vasculature |url=https://onlinelibrary.wiley.com/doi/10.1111/j.1748-1716.2010.02249.x |journal=Acta Physiologica |language=en |volume=203 |issue=1 |pages=127–137 |doi=10.1111/j.1748-1716.2010.02249.x}}</ref>.
Weston's research focuses on the physiology and pharmacology of ion channels in blood vessels and on the development of drugs to treat vascular disease associated with hypertension, diabetes and obesity. During the 1980s he discovered a new class of agent which he designated the "[[potassium channel opener]]"<ref>{{Cite journal |last=Duty |first=Susan |last2=Weston |first2=Arthur H. |date=1990-12-01 |title=Potassium Channel Openers |url=https://doi.org/10.2165/00003495-199040060-00002 |journal=Drugs |language=en |volume=40 |issue=6 |pages=785–791 |doi=10.2165/00003495-199040060-00002 |issn=1179-1950}}</ref> and this has formed the basis of many on-going research programmes within the pharmaceutical industry. These studies led to the further discovery that blood vessels produce a relaxing factor that he termed "endothelium-derived hyperpolarizing factor" (EDHF)<ref>{{Cite journal |last=Busse |first=Rudi |last2=Edwards |first2=Gillian |last3=Félétou |first3=Michel |last4=Fleming |first4=Ingrid |last5=Vanhoutte |first5=Paul M. |last6=Weston |first6=Arthur H. |date=2002-08-01 |title=EDHF: bringing the concepts together |url=https://www.cell.com/trends/pharmacological-sciences/abstract/S0165-6147(02)02050-3 |journal=Trends in Pharmacological Sciences |language=English |volume=23 |issue=8 |pages=374–380 |doi=10.1016/S0165-6147(02)02050-3 |issn=0165-6147 |pmid=12377579}}</ref>. His most recent discoveries in Manchester concern the existence and role of a special calcium-sensing receptor in the endothelium of blood vessels<ref>{{Cite journal |last=Weston |first=A. H. |last2=Geraghty |first2=A. |last3=Egner |first3=I. |last4=Edwards |first4=G. |date=September 2011 |title=The vascular extracellular calcium-sensing receptor: an update: Ca2+-sensing in the vasculature |url=https://onlinelibrary.wiley.com/doi/10.1111/j.1748-1716.2010.02249.x |journal=Acta Physiologica |language=en |volume=203 |issue=1 |pages=127–137 |doi=10.1111/j.1748-1716.2010.02249.x}}</ref>.
Line 49: Line 43:


== References ==
== References ==

<!-- Inline citations added to your article will automatically display here. See en.wikipedia.org/wiki/WP:REFB for instructions on how to add citations. -->
{{reflist}}
{{reflist}}

{{DEFAULTSORT:Weston, Arthur}}
[[Category:1944 births]]
[[Category:Living people]]

Revision as of 03:09, 5 January 2023

Professor
Arthur Weston
FMedSci FBPhS HonFBPhS
Born
Arthur Henry Weston

(1944-05-31) 31 May 1944 (age 80)
Hull, United Kingdom
CitizenshipUnited Kingdom
Alma materUniversity of Manchester (BSc, MSc, PhD, DSc)
Known forThe discovery and characterisation of potassium channel openers (KCOs)
Children2
AwardsRodolfo Paoletti Medal (2015).[1]

HonFBPhS (2012)[1]

Gaddum Medal (2008)[1]

FBPhS (2004)[1]

FMedSci (2001)[1]

Humboldt Fellowship (1974-75)[1]
Scientific career
InstitutionsUniversity of Manchester, University of Marburg, University of Heidelberg, Kyushu University, Magdalen College, Oxford

Arthur Henry Weston FMedSci FBPhS HonFBPhS is Emeritus Professor at the University of Manchester, where he was previously Leech Professor of Pharmacology from 1989-2011[2]. He is an internationally recognised authority on smooth muscle and, in particular, on the physiology and pharmacology of potassium channels in this tissue. In a series of seminal publications he identified the properties and effects of the so-called "potassium channel openers”, and his subsequent work on the organ specificity of these drugs is of great practical value.

Early life and education

Weston was born in 1944 in Cottingham, son of Arthur Edward Weston and Betty Nutt Weston (née Wetherell)[3]. He won a Scholarship to Hymers College, Hull in 1955 and entered the Victoria University of Manchester in 1962[4]. After graduating BSc in Pharmacy with First Class Honours in Pharmacology (1966), he obtained his MSc (1968) and PhD (1970)[5].

Career and research

Weston was made Lecturer in Pharmacology at Manchester in 1970, Senior Lecturer in 1979, Reader in 1987 and Professor in 1989[6]. In 1974, he was awarded an Alexander von Humboldt Fellowship to study in the Department of Physiology in the University of Marburg and a senior Humboldt Fellowship to study in the Department of Physiology in the University of Heidelberg in 1985. During 1987, he was a Royal Society-funded visiting Professor in the Department of Pharmacology, University of Kyushu, Japan. In 2011, Weston became a Visiting Fellow at Magdalen College, Oxford. At a national level, he was Honorary Treasurer, a Director and Trustee of the British Pharmacological Society (BPS) for the 8 years from 1999-2008.[7]

Weston's research focuses on the physiology and pharmacology of ion channels in blood vessels and on the development of drugs to treat vascular disease associated with hypertension, diabetes and obesity. During the 1980s he discovered a new class of agent which he designated the "potassium channel opener"[8] and this has formed the basis of many on-going research programmes within the pharmaceutical industry. These studies led to the further discovery that blood vessels produce a relaxing factor that he termed "endothelium-derived hyperpolarizing factor" (EDHF)[9]. His most recent discoveries in Manchester concern the existence and role of a special calcium-sensing receptor in the endothelium of blood vessels[10].

Awards and honours

In 2001, Weston was elected Fellow of the Academy of Medical Sciences (FMedSci)[11] and in 2004 to a Fellowship of the British Pharmacological Society (FBPhS)[12]. At the IUPHAR Meeting in Beijing in July 2006, he was elected President of EPHAR, the Federation of European Pharmacological Societies. In 2008, he was made Honorary Member of the Finnish Pharmacological Society and awarded the Gaddum Medal by the British Pharmacological Society[13]. At the 2010 WorldPharma Meeting in Copenhagen, Weston was presented with a special commemorative award and plaque for his services to European pharmacology, and in 2014 he was awarded the Rodolfo Paoletti Medal by EPHAR[14]

Personal life

Weston married Dr. Kathleen Margaret Goodison in 1967 and they have two children, Sophie (b. 1970) and Matthew (b. 1972)[15]. Weston is an enthusiastic gardener and active member of the Royal Horticultural Society, where he is a member of the Crocosmia Annual General Meeting Forum and is currently serving on the Geum AGM Trial Committee[16].

References

  1. ^ a b c d e f "https://www.bps.ac.uk/about/who-we-are/honorary-fellows-directory/professor-arthur-weston/01ff56b2-d7f6-e311-88a7-001dd8b721a7"
  2. ^ "Professor Arthur Weston | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 2022-10-17.
  3. ^ "Weston, Prof. Arthur Henry, (born 31 May 1944), Leech Professor of Pharmacology, University of Manchester, 1990–2011, now Emeritus". WHO'S WHO & WHO WAS WHO. doi:10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-43701?rskey=fgx3np&result=1. Retrieved 2022-12-02.
  4. ^ "Weston, Prof. Arthur Henry, (born 31 May 1944), Leech Professor of Pharmacology, University of Manchester, 1990–2011, now Emeritus". WHO'S WHO & WHO WAS WHO. doi:10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-43701?rskey=fgx3np&result=1. Retrieved 2022-12-02.
  5. ^ "Weston, Prof. Arthur Henry, (born 31 May 1944), Leech Professor of Pharmacology, University of Manchester, 1990–2011, now Emeritus". WHO'S WHO & WHO WAS WHO. doi:10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-43701?rskey=fgx3np&result=1. Retrieved 2022-12-02.
  6. ^ "Weston, Prof. Arthur Henry, (born 31 May 1944), Leech Professor of Pharmacology, University of Manchester, 1990–2011, now Emeritus". WHO'S WHO & WHO WAS WHO. doi:10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-43701?rskey=fgx3np&result=1. Retrieved 2022-12-02.
  7. ^ "Weston, Prof. Arthur Henry, (born 31 May 1944), Leech Professor of Pharmacology, University of Manchester, 1990–2011, now Emeritus". WHO'S WHO & WHO WAS WHO. doi:10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-43701?rskey=fgx3np&result=1. Retrieved 2022-12-02.
  8. ^ Duty, Susan; Weston, Arthur H. (1990-12-01). "Potassium Channel Openers". Drugs. 40 (6): 785–791. doi:10.2165/00003495-199040060-00002. ISSN 1179-1950.
  9. ^ Busse, Rudi; Edwards, Gillian; Félétou, Michel; Fleming, Ingrid; Vanhoutte, Paul M.; Weston, Arthur H. (2002-08-01). "EDHF: bringing the concepts together". Trends in Pharmacological Sciences. 23 (8): 374–380. doi:10.1016/S0165-6147(02)02050-3. ISSN 0165-6147. PMID 12377579.
  10. ^ Weston, A. H.; Geraghty, A.; Egner, I.; Edwards, G. (September 2011). "The vascular extracellular calcium-sensing receptor: an update: Ca2+-sensing in the vasculature". Acta Physiologica. 203 (1): 127–137. doi:10.1111/j.1748-1716.2010.02249.x.
  11. ^ "Professor Arthur Weston | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 2022-10-19.
  12. ^ British Pharmacological Society. "Professor Arthur Weston FMedSci DSc".
  13. ^ British Pharmacological Society. "Gaddum International Lecture Past winners".
  14. ^ "EPHAR - The Federation of European Pharmacological Societies". www.ephar.org. Retrieved 2022-10-19.
  15. ^ "Weston, Prof. Arthur Henry, (born 31 May 1944), Leech Professor of Pharmacology, University of Manchester, 1990–2011, now Emeritus". WHO'S WHO & WHO WAS WHO. doi:10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-43701?rskey=fgx3np&result=1. Retrieved 2022-12-02.
  16. ^ "View the Royal Horticultural Society's plant trials and awards / RHS Gardening". www.rhs.org.uk. Retrieved 2022-10-19.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Arthur_Weston_(scientist)&oldid=1131644450"