Non-noradrenergic, non-cholinergic transmitter
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A non-noradrenergic, non-cholinergic transmitter (NANC) is a neurotransmitter of the enteric nervous system (ENS) that is neither acetylcholine, norepinephrine, nor epinephrine.
Comparison table
This table compares different NANCs in the PNS:
Neurotransmitter | Type | Location[1] | Function[1] |
---|---|---|---|
ATP | non-peptide | postganglionic sympathetic neurons (e.g. in blood vessels & vas deferens) | Fast depolarization/contraction (vasoconstriction) |
GABA | non-peptide | ENSs | peristalsis |
5-HT | non-peptide | ENSs | peristalsis |
dopamine | non-peptide | some SNSs (e.g. kidney) | vasodilation |
NO | non-peptide | gastric nerves & Pelvic Nerve |
|
NPY | peptide | postganglionic sympathetic neurons (e.g. blood vessels) |
|
VIP | peptide |
|
|
GnRH | peptide | sympathetic ganglia |
|
substance P | peptide |
| |
CGRP | peptide | non-myelinated sensory neurons |
References
- ^ a b Unless else specified in table, then ref is: Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 132