Temoporfin
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(Redirected from Foscan)
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AHFS/Drugs.com | International Drug Names |
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ECHA InfoCard | 100.152.970 |
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Formula | C44H32N4O4 |
Molar mass | 680.764 g·mol−1 |
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Temoporfin (INN) is a photosensitizer (based on chlorin) used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck[1] .[2] It is marketed in the European Union under the brand name Foscan. The U.S. Food and Drug Administration (FDA) declined to approve Foscan in 2000. The EU approved its use in June 2001.[3]
Good results were obtained in 21 of 35 patients treated in Germany.[4]
It is photoactivated at 652 nm[2] i.e. by red light.
Patients can remain photosensitive for several weeks after treatment.[2]
References
- ^ Lorenz KJ, Maier H (April 2008). "[Squamous cell carcinoma of the head and neck. Photodynamic therapy with Foscan]". Hno (in German). 56 (4): 402–409. doi:10.1007/s00106-007-1573-1. PMID 17516041.
- ^ a b c O'Connor AE, Gallagher WM, Byrne AT (2009). "Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy". Photochemistry and Photobiology. 85 (5): 1053–1074. doi:10.1111/j.1751-1097.2009.00585.x. PMID 19682322. S2CID 205950773.
- ^ "Foscan approval saves Scotia's skin". HighBeam. Archived from the original on 2012-11-04.
- ^ Lorenz KJ, Maier H (December 2009). "Photodynamic therapy with meta-tetrahydroxyphenylchlorin (Foscan) in the management of squamous cell carcinoma of the head and neck: experience with 35 patients". European Archives of Oto-Rhino-Laryngology. 266 (12): 1937–1944. doi:10.1007/s00405-009-0947-2. PMID 19290535. S2CID 5892034.
Further reading
- Marchal S, François A, Dumas D, Guillemin F, Bezdetnaya L (March 2007). "Relationship between subcellular localisation of Foscan and caspase activation in photosensitised MCF-7 cells". British Journal of Cancer. 96 (6): 944–51. doi:10.1038/sj.bjc.6603631. PMC 2360096. PMID 17325708.