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covalent acyl-enzyme intermediate. The second step (4) is the deacylation step. It is important to note that the group H+, initially found on the enzyme, but...

to the enzyme as an acyl-enzyme intermediate. Although general-acid catalysis for breakdown of the First and Second tetrahedral intermediate may occur...

protein, releasing the first half of the product. This covalent acyl-enzyme intermediate is then hydrolyzed by activated water to complete catalysis by...

reaction) to the acyl–enzyme intermediate triggers the release of the product from the enzyme. Each of the tetrahedral reaction intermediates that occur during...

These enzymes possess a unique, highly conserved Ser-Ser-Lys catalytic triad used for amide hydrolysis, although the catalytic mechanism for acyl-enzyme intermediate...

Enzymes (/ˈɛnzaɪmz/) are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called...

peptide backbone. This forms a covalent acyl-enzyme intermediate and frees the amino terminus of the peptide. The enzyme is deacylated by a water molecule and...

in the active site and the formation of the acyl-enzyme intermediate. In the figure to the right, the enzyme produces E* rapidly in the first few seconds...

D-alanine, and the formation of the acyl-enzyme. The second step involves the breakdown of the acyl-enzyme intermediate and the formation of a new peptide...

activated acyl group into the mitochondria for further breakdown. The first oxidation step in the peroxisome is catalyzed by the enzyme acyl-CoA oxidase...

rate-determining step in pepsin-catalysed reactions, and evidence against an acyl-enzyme intermediate". The Biochemical Journal. 113 (2): 369–75. doi:10.1042/bj1130369...

covalent acyl-enzyme intermediate, releasing the first product. Secondly the intermediate is hydrolysed by water to regenerate the free enzyme and release...

substrates for medium chain acyl-CoA synthase are 4-11 carbon fatty acids. The enzyme acyl-CoA thioesterase takes of the acyl-CoA to form a free fatty acid...

back from the negative oxygen to recreate the bond, generating an acyl-enzyme intermediate. Now, water comes into the reaction. Water replaces the N-terminus...

synthesis. The enzyme catalyzes the reaction: Acetyl-CoA + n malonyl-CoA + 4n NADPH + 4n H+ ⇌ {\displaystyle \rightleftharpoons } long-chain-acyl-CoA + n CoA...

slow tight-binding substrate, trapping the target protein in the acyl-enzyme intermediate form, resulting in apparent observed inhibition. It inhibits a...

The enzyme 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59) catalyzes the chemical reaction (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein]...

3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61) is an enzyme that catalyzes the chemical reaction (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein]...

non-protein chemical compound or metallic ion that is required for an enzyme's role as a catalyst (a catalyst is a substance that increases the rate of...

ester-bond between the enzyme and the substrate. This covalent complex between enzyme and substrate is called an acyl-enzyme intermediate. For standard substrates...