Translational efficiency

In cell biology, translational efficiency or translation efficiency is the rate of mRNA translation into proteins within cells.

It has been measured in protein per mRNA per hour.^[1] Several RNA elements within mRNAs have been shown to affect the rate. These include miRNA and protein binding sites. RNA structure may also affect translational efficiency through the altered protein or microRNA binding.^[2]

References

^ Schwanhäusser, Björn; Busse, Dorothea; Li, Na; Dittmar, Gunnar; Schuchhardt, Johannes; Wolf, Jana; Chen, Wei; Selbach, Matthias (May 2011). "Global quantification of mammalian gene expression control" (PDF). Nature. 473 (7347): 337–342. Bibcode:2011Natur.473..337S. doi:10.1038/nature10098. PMID 21593866. S2CID 205224972.
^ Lu, YF; Mauger, DM; Goldstein, DB; Urban, TJ; Weeks, KM; Bradrick, SS (4 November 2015). "IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance". Scientific Reports. 5: 16037. Bibcode:2015NatSR...516037L. doi:10.1038/srep16037. PMC 4631997. PMID 26531896.

External links

[1] Transterm database online

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[1] Schwanhäusser, Björn; Busse, Dorothea; Li, Na; Dittmar, Gunnar; Schuchhardt, Johannes; Wolf, Jana; Chen, Wei; Selbach, Matthias (May 2011). "Global quantification of mammalian gene expression control" (PDF). Nature. 473 (7347): 337–342. Bibcode:2011Natur.473..337S. doi:10.1038/nature10098. PMID 21593866. S2CID 205224972.

[2] Lu, YF; Mauger, DM; Goldstein, DB; Urban, TJ; Weeks, KM; Bradrick, SS (4 November 2015). "IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance". Scientific Reports. 5: 16037. Bibcode:2015NatSR...516037L. doi:10.1038/srep16037. PMC 4631997. PMID 26531896.

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See also

References

External links