SARS-CoV-2 Zeta variant

Source: Wikipedia, the free encyclopedia.

Zeta variant, also known as lineage P.2,[a] is a variant of SARS-CoV-2, the virus that causes COVID-19. It was first detected in the state of Rio de Janeiro; it harbors the E484K mutation, but not the N501Y and K417T mutations. It evolved independently in Rio de Janeiro without being directly related to the Gamma variant from Manaus.[1][2]

Under the simplified naming scheme proposed by the World Health Organization, P.2 was labeled "Zeta variant", and was considered a variant of interest (VOI), but not a variant of concern.[3] A second wave was preceded in November 2020 by an increase in the prevalence of the Zeta variant among genetic sequences from São Paulo state, deposited into the GISAID database.[4] As of July 2021, Zeta is no longer considered a variant of interest by the WHO.[5]


The Zeta genome has 3 amino acid mutations: E484K, D614G, and V1176F, all of which are found in the virus's spike protein code.[6] According to the Centers for Disease Control and Prevention, F565L has been detected in some of the Zeta variant sequences, but not all.[7]

  • Amino acid mutations of SARS-CoV-2 Zeta variant plotted on a genome map of SARS-CoV-2 with a focus on the spike.[6]

    Amino acid mutations of SARS-CoV-2 Zeta variant plotted on a genome map of SARS-CoV-2 with a focus on the spike.[6]


  1. ^ A sub-lineage of B.1.1.28


  1. ^ "PANGO lineages Lineage P.2". COV lineages. Retrieved January 28, 2021. P.2… Alias of B., Brazilian lineage
  2. ^ Voloch, Carolina M.; da Silva Francisco, Ronaldo; de Almeida, Luiz G. P.; Cardoso, Cynthia C.; Brustolini, Otavio J.; Gerber, Alexandra L.; Guimarães, Ana Paula de C.; Mariani, Diana; da Costa, Raissa Mirella; Ferreira, Orlando C.; Cavalcanti, Adriana Cony (April 26, 2021). "Genomic Characterization of a Novel SARS-CoV-2 Lineage from Rio de Janeiro, Brazil". Journal of Virology. 95 (10). doi:10.1128/JVI.00119-21. ISSN 0022-538X. PMC 8139668. PMID 33649194.
  3. ^ "Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings". Virological. January 12, 2021. Retrieved June 26, 2021.
  4. ^ Ranzani, Otavio (2021). "Effectiveness of the CoronaVac vaccine in the elderly population during a Gamma variant-associated epidemic of COVID-19 in Brazil" (PDF). medRxiv. doi:10.1101/2021.05.19.21257472. S2CID 234893958. {{cite journal}}: Cite journal requires |journal= (help)
  5. ^ "Tracking SARS-CoV-2 variants". World Health Organization.{{cite web}}: CS1 maint: url-status (link)
  6. ^ a b "Spike Variants: Zeta variant, aka P.2". Stanford University Coronavirus Antiviral & Resistance Database. July 1, 2021. Retrieved July 5, 2021.
  7. ^ "SARS-CoV-2 Variant Classifications and Definitions". Centers for Disease Control and Prevention. February 11, 2020. Retrieved July 5, 2021.