NSP2 (rotavirus)
| NSP2 (rotavirus) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifiers | |||||||||
| Symbol | Rota_NS35 | ||||||||
| Pfam | PF02509 | ||||||||
| InterPro | IPR003668 | ||||||||
| CATH | 2gu0 | ||||||||
| SCOP2 | 2r7j / SCOPe / SUPFAM | ||||||||
| |||||||||
| Protein folds into two domains. | |||||||||
NSP2 (NS35), is a rotavirus nonstructural RNA-binding protein that accumulates in cytoplasmic inclusions (viroplasms) and is required for genome replication.[1] NSP2 is closely associated in vivo with the viral replicase.[2] The non-structural protein NSP5 plays a role in the structure of viroplasms mediated by its interaction with NSP2.[3]
References
- ^ Kattoura MD, Chen X, Patton JT (August 1994). "The rotavirus RNA-binding protein NS35 (NSP2) forms 10S multimers and interacts with the viral RNA polymerase". Virology. 202 (2): 803–813. doi:10.1006/viro.1994.1402. PMID 8030243.
- ^ Aponte C, Poncet D, Cohen J (February 1996). "Recovery and characterization of a replicase complex in rotavirus-infected cells by using a monoclonal antibody against NSP2". Journal of Virology. 70 (2): 985–91. doi:10.1128/JVI.70.2.985-991.1996. PMC 189903. PMID 8551639.
- ^ Fabbretti E, Afrikanova I, Vascotto F, Burrone OR (February 1999). "Two non-structural rotavirus proteins, NSP2 and NSP5, form viroplasm-like structures in vivo". The Journal of General Virology. 80 (2): 333–9. doi:10.1099/0022-1317-80-2-333. PMID 10073692.
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