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remnants and IDL. In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. It belongs to the low density lipoprotein receptor...

PCSK9 is blocked, the LDL-LDLR complex separates during trafficking, with the LDL digested in the lysosome, but the LDLRs instead recycled back to the...

such as VLDL and IDL. About 1 in 100 to 200 people have mutations in the LDLR gene that encodes the LDL receptor protein, which normally removes LDL from...

G. N. (Jan 2010). "Dietary Vaccenic Acid Has Antiatherogenic Effects in LDLr-/- Mice". The Journal of Nutrition. 140 (1): 18–24. doi:10.3945/jn.109.105163...

APOE interacts significantly with the low-density lipoprotein receptor (LDLR), which is essential for the normal processing (catabolism) of triglyceride-rich...

multicellular organisms. There are seven members of the LDLR family in mammals, namely: LDLR VLDL receptor (VLDLR) ApoER2, or LRP8 Low density lipoprotein...

much higher than that found for LDLR. Hence, these gene comparisons suggest that VLDLR and LDLR diverged before the LDLRs did among vertebrates. VLDLR binds...

hepatic steatosis in obese (ob/ob) mice ; reversal of atherosclerosis in LDLR knock-out mice ; inhibition of the growth of malignancy in rodents ; stimulation...

Hospital, Jaipur successfully conducted its first Live Donor Liver Transplant (LDLR), making it amongst the top few multi-organ transplant centers in Northern...

alpha-chain and an 85 kDa beta-chain associated noncovalently. As a member of the LDLR family, LRP1 contains cysteine-rich complement-type repeats, EGF (gene) repeats...

PDGF0, APOA5, MNF1ASM283, COL4A1, HHIPC1, SMAD3, ADAMTS7, RAS1, SMG6, SNF8, LDLR, SLC5A3, MRPS6, KCNE2. The risk of having a myocardial infarction increases...

population may exhibit a genetic founder effect. One variation, G197del LDLR which is implicated in familial hypercholesterolemia, has been dated to the...

lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice". European Journal of Clinical Investigation. 36 (3):...

four-stranded beta-propeller repeats found in low-density lipoprotein receptors (LDLR). The six YWTD repeats together fold into a six-bladed beta-propeller (InterPro: IPR011042)...

lipoprotein (LDL) receptor (LDLR). The removal of LDL particles from blood circulation is enhanced when the number of LDLR on hepatocytes increases. Due...

et al. (January 2010). "Dietary vaccenic acid has antiatherogenic effects in LDLr-/- mice". The Journal of Nutrition. 140 (1): 18–24. doi:10.3945/jn.109.105163...

hypercholesterolemia Endocrinology, chemical pathology Autosomal dominant LDLR 1/69  Familial hyperinsulinism Gastroenterology, endocrinology, pediatrics...

endocytosis mediated by a receptor which is a low-density lipoprotein receptor (LDLR). Yolk is a lipoprotein composed of proteins, phospholipids and neutral fats...

the PCSK9 protein. PCSK9 binds to the low-density lipoprotein receptor (LDLR) (which takes cholesterol out of circulation), and that binding leads to...

metabolism disorders. In familial hypercholesterolemia, a mutation in the LDLR, PCSK9, or APOB is usually the reason for this and these mutations result...