Kurkinorin
Appearance
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Names | |
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IUPAC name
Methyl (2S,4aR,6aR,7R,10aR,10bR)-9-benzoyloxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,10a-hexahydro-1H-benzo[f]isochromene-7-carboxylate
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Identifiers | |
3D model (JSmol)
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PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C28H28O8 | |
Molar mass | 492.524 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Kurkinorin is a non-nitrogenous, extremely selective centrally acting μ-opioid receptor agonist derived from salvinorin A[1] with no sedating or rewarding effects.[2]
See also
References
- ^ Crowley RS, Riley AP, Alder AF, Anderson RJ, Luo D, Kaska S, Maynez P, Kivell BM, Prisinzano TE (June 2020). "Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ-Opioid Receptor". ACS Chemical Neuroscience. 11 (12): 1781–1790. doi:10.1021/acschemneuro.0c00191. PMC 7359744. PMID 32383854.
- ^ Shivaperumal, Nirajmohan (May 18, 2017). Investigating the analgesic properties of Kurkinorin, a novel mu-opioid receptor analogue of Salvinorin A (Masters). Victoria University of Wellington.