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Micrograph showing hemophagocytosis in the spleen. H&E stain

Hemophagocytosis is phagocytosis by histiocytes of erythrocytes, leukocytes, platelets, and their precursors[1] in bone marrow and other tissues.

It is part of the presentation of hemophagocytic lymphohistiocytosis and Macrophage activation syndrome. It has also been seen at autopsy of people who died of COVID-19.[2]


  1. ^ "Hemophagocytic Syndromes and Infection".
  2. ^ Satturwar, Swati; Fowkes, Mary; Farver, Carol; Wilson, Allecia M.; Eccher, Albino; Girolami, Ilaria; Pujadas, Elisabet; Bryce, Clare; Salem, Fadi; El Jamal, Siraj M.; Paniz-Mondolfi, Alberto; Petersen, Bruce; Gordon, Ronald E.; Reidy, Jason; Fraggetta, Filippo; Marshall, Desiree A.; Pantanowitz, Liron (2021). "Postmortem Findings Associated With SARS-CoV-2". American Journal of Surgical Pathology. Publish Ahead of Print. doi:10.1097/PAS.0000000000001650. ISSN 0147-5185.