CCL14

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Structures	Swiss-model
Domains	InterPro

chemokine (C-C motif) ligand 14
chemokine (C-C motif) ligand 14
Identifiers
Symbol	CCL14
Alt. symbols	SCYA14, HCC-1, HCC-3, NCC-2, SCYL2, CKb1, MCIF
NCBI gene	6358
HGNC	10612
OMIM	601392
RefSeq	NM_032962
UniProt	Q16627
Other data
Locus	Chr. 17 q11.2
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Chemokine (C-C motif) ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. It is also commonly known as HCC-1. It is produced as a protein precursor that is processed to generate a mature active protein containing 74 amino acids that and is 46% identical in amino acid composition to CCL3 and CCL4. This chemokine is expressed in various tissues including spleen, bone marrow, liver, muscle, and gut.^[1] CCL14 activates monocytes, but does not induce their chemotaxis. Human CCL14 is located on chromosome 17 within a cluster of other chemokines belonging to the CC family.^[2]

References

^ Schulz-Knappe et al., HCC-1, a novel chemokine from human plasma. J. Exp. Med., 1996, 183: 295-299.
^ Naruseet al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics, 1996, 34: 236-240.

[1] Schulz-Knappe et al., HCC-1, a novel chemokine from human plasma. J. Exp. Med., 1996, 183: 295-299.

[2] Naruseet al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics, 1996, 34: 236-240.

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