Beta1-adrenergic agonist
Beta1-adrenergic agonists, also known as Beta1-adrenergic receptor agonists, are a class of drugs that bind selectively to the beta-1 adrenergic receptor. As a result, they act more selectively upon the heart. Beta-adrenoceptors typically bind to norepinephrine release by sympathetic adrenergic nerves and to circulating epinephrine. The effect of B-adrenoceptors is cardiac stimulation, such as increased heart rate, heart contractility, heart conduction velocity and heart relaxation.[1]
Examples
Examples include:
- denopamine[2][3] β1 agonist
- dobutamine β1>β2 agonist
- xamoterol β1 partial agonist
- epinephrine
- Epinephrine is a non-selective beta agonist, this means it also stimulates the beta 2 adrenergic receptor. Therefore, epinephrine is a Beta2-adrenergic agonist.
- Isoprenaline
References
- ^ Sakuma, Tsutomu; Hida, Mieko; Nambu, Yoshihiro; Osanai, Kazuhiro; Toga, Hirohisa; Takahashi, Keiji; Ohya, Nobuo; Inoue, Masao; Watanabe, Yoh (2001). "Beta1-Adrenergic Agonist Is a Potent Stimulator of Alveolar Fluid Clearance in Hyperoxic Rat Lungs". The Japanese Journal of Pharmacology. 85 (2): 161–166. doi:10.1254/jjp.85.161. ISSN 0021-5198. PMID 11286398.
- ^ Sakuma T, Hida M, Nambu Y, et al. (February 2001). "Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs". Jpn. J. Pharmacol. 85 (2): 161–6. doi:10.1254/jjp.85.161. PMID 11286398.
- ^ Nishio R, Matsumori A, Shioi T, et al. (September 1998). "Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart". J. Am. Coll. Cardiol. 32 (3): 808–15. doi:10.1016/S0735-1097(98)00314-3. hdl:2433/181223. PMID 9741531.